Search results for "INTEGRITY"
showing 10 items of 134 documents
Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex
2017
AbstractWhile deep brain stimulation of the subthalamic nucleus (STN-DBS) has evolved to an evidence-based standard treatment for Parkinson’s disease (PD), the targeted cerebral networks are poorly described and no objective predictors for the postoperative clinical response exist. To elucidate the systemic mechanisms of DBS, we analysed cerebral grey matter properties using cortical thickness measurements and addressed the dependence of structural integrity on clinical outcome. Thirty one patients with idiopathic PD without dementia (23 males, age: 63.4 ± 9.3, Hoehn and Yahr: 3.5 ± 0.8) were selected for DBS treatment. The patients underwent whole-brain preoperative T1 MR-Imaging at 3 T. G…
Sng1 associates with Nce102 to regulate the yeast Pkh–Ypk signalling module in response to sphingolipid status
2016
International audience; All cells are delimited by biological membranes, which are consequently a primary target of stress-induced damage. Cold alters membrane functionality by decreasing lipid fluidity and the activity of membrane proteins. In Saccharomyces cerevisiae, evidence links sphingolipid homeostasis and membrane phospholipid asymmetry to the activity of the Ypk1/2 proteins, the yeast orthologous of the mammalian SGK1-3 kinases. Their regulation is mediated by different protein kinases, including the PDK1 orthologous Pkh1/2p, and requires the function of protein effectors, among them Nce102p, a component of the sphingolipid sensor machinery. Nevertheless, the mechanisms and the act…
Preservation of Multiple Mammalian Tissues to Maximize Science Return from Ground Based and Spaceflight Experiments.
2016
Background Even with recent scientific advancements, challenges posed by limited resources and capabilities at the time of sample dissection continue to limit the collection of high quality tissues from experiments that can be conducted only infrequently and at high cost, such as in space. The resources and time it takes to harvest tissues post-euthanasia, and the methods and duration of long duration storage, potentially have negative impacts on sample quantity and quality, thereby limiting the scientific outcome that can be achieved. Objectives The goals of this study were to optimize methods for both sample recovery and science return from rodent experiments, with possible relevance to b…
PIWIL3 Forms a Complex with TDRKH in Mammalian Oocytes.
2019
P-element induced wimpy testis (PIWIs) are crucial guardians of genome integrity, particularly in germ cells. While mammalian PIWIs have been primarily studied in mouse and rat, a homologue for the human PIWIL3 gene is absent in the Muridae family, and hence the unique function of PIWIL3 in germ cells cannot be effectively modeled by mouse knockouts. Herein, we investigated the expression, distribution, and interaction of PIWIL3 in bovine oocytes. We localized PIWIL3 to mitochondria, and demonstrated that PIWIL3 expression is stringently controlled both spatially and temporally before and after fertilization. Moreover, we identified PIWIL3 in a mitochondrial-recruited three-membered complex…
Trend of Drug Abuse in 2011– 2014 in Italy
2017
Doping, although was born as a medication and not with the purpose of enhancing performance, is a widespread practice in all sports, between amateur and gym-goers. The Italian sports federations were in second place worldwide for positive doping-test, after Russia. This review focuses on the analysis of data collected by Italian National Olympic Committee (CONI) in the 2012–2014 period, showing that the most commonly used substances were anabolic androgenic agents, glucocorticoids, diuretics and stimulants. Prevention in doping could be a key to limit the damage caused by this harmful practice both, for the physical health and the athlete’s moral integrity and anti-doping campai…
Les actions du chlorfenprop-methyl sur l'integrite membranaire dans les mitochondries des plantes
1983
Summary The action of chlorfenprop-methyl, chlorfenprop and its cysteine conjugate was studied on potato tuber mitochondria. Chlorfenprop-methyl altered membrane structure at 250 μM. leading to a loss of membrane integrity. Chlorfenprop and its cysteine conjugate were without any significant effects. From what is known about the rapid hydrolysis of chlorfenprop-methyl in plant tissues and from the results presented in this paper, it was deduced that alteration in intra-cellular membrane integrity is not a mechanism of phytotoxic action for chlorfenprop-methyl. Resume Les actions du chlorfenprop-methyl sur l'integrite membranaire dans les mitochondries des plantes Les actions du chlorfenprop…
Unlock ways to share data on peer review
2020
Peer review is the defining feature of scholarly communication. In a 2018 survey of more than 11, 000 researchers, 98% said that they considered peer review important or extremely important for ensuring the quality and integrity of scholarly communication.
Filling the Gap in the Metallacrown Family: The 9‐MC‐3 Chromium Metallacrown
2021
Abstract In this work, we report on a long‐sought missing complex in the metallacrown family. We synthesized and characterized the novel chromium metallacrown (MC) complex {CrIII(μ 2‐piv)3[9‐MCCr(III)N(shi)‐3](morph)3}⋅MeOH (in which shi3−=salicyl hydroxamate, piv=pivalate, and morph=morpholine). The MC with a 9‐MC‐3 cavity of kinetically inert chromium(III) ions was synthesized by a solvothermal reaction. Magnetization measurements reveal a high spin ground state.
Neutralidad y honorabilidad del árbitro: : De la ética a la diligencia
2021
One of the main principles of arbitration is that the arbitral tribunal must be independent, impartial, neutral and diligent in carrying out its duties throughout the arbitration proceedings. However, the sophistication and complexity of arbitration as an extra-judicial dispute resolution procedure can undermine confidence in the efficiency of the system. In this regard, the professional (arbitral) ethics and the honourability of the arbitrator are of major importance. This article aims to highlight the importance of the neutrality of the arbitrator, the integrity of the arbitration and the reputation of this procedure
Comparison of service tactic formation on players’ movements and point outcome between national and beginner level padel
2021
The aim of this study was to analyze the influence of service tactic formation on players’ movements and point outcome at two different performance levels. The sample contained 2,148 points corresponding to 18 matches from two male padel indoor tournaments. Players were classified according to their game level: high-level (N = 36; age = 33.3 ± 6.9 years) and beginner (N = 36; age = 35.4 ± 6.8 years). Variables pertaining to service tactic formation (conventional or Australian), point outcome and movement patterns were analysed from the matches through systematic observation. The results showed how high-level players used a significantly higher percentage of the Australian formation than beg…