Search results for "INTERACTIONS"
showing 10 items of 1963 documents
XPL, a Presentation Language based on User Interface Design Pattern
2007
The great diversity of presentations in software applications deals with fulfillment of various type of graphic interface constructions related to different programming Languages. Moreover, in the Internet era html pages play a main role because of the increasing complexity of Web applications. In Software Engineering, the use of design patterns is proven remarkable for the design and reuse of software components. Visual Design. Patterns (ViDP) are useful to define interaction schemas between. user and computer. By the some token, visual design. patterns are useful to incorporate common interfaces of interaction, schemas between user and computer. This paper describes the eXtensible Present…
Cytoplasmic Parvovirus Capsids Recruit Importin Beta for Nuclear Delivery
2019
Parvoviruses are an important platform for gene and cancer therapy. Their cell entry and the following steps, including nuclear import, are inefficient, limiting their use in therapeutic applications. Two models exist on parvoviral nuclear entry: the classical import of the viral capsid using nuclear transport receptors of the importin (karyopherin) family or the direct attachment of the capsid to the nuclear pore complex leading to the local disintegration of the nuclear envelope. Here, by laser scanning confocal microscopy and in situ proximity ligation analyses combined with coimmunoprecipitation, we show that infection requires importin β-mediated access to the nuclear pore complex and …
Low density lipoproteins and human serum albumin as the carriers of squalenoylated drugs: insights from molecular simulations
2018
We have studied the interaction of three clinically promising squalenoylated drugs (gemcitabine-squalene, adenine-squalene, and doxorubicin-squalene) with low-density lipoproteins (LDL) by means of atomistic molecular dynamics simulations. It is shown that all studied squalenoylated drugs accumulate inside the LDL particles. This effect is promoted by the squalene moiety, which acts as an anchor and drives the hydrophilic drugs into the hydrophobic core of the LDL lipid droplet. Our data suggest that LDL particles could be a universal carriers of squalenoylated drugs in the bloodstream. Interaction of gemcitabine-squalene with human serum albumin (HSA) was also studied by ensemble of dockin…
Search for the exotic Θ+ resonance in the NOMAD experiment
2006
12 pages, 16 figures.-- PACS nrs.: 13.15.+g; 13.60.Le; 13.87.Fh; 14.40.Ev.-- ISI Article Identifier: 000243973100007.-- ArXiv pre-print available at: http://arxiv.org/abs/hep-ex/0612063.-- et al.
Harmonic oscillator model for the atom-surface Casimir-Polder interaction energy
2012
In this paper we consider a quantum harmonic oscillator interacting with the electromagnetic radiation field in the presence of a boundary condition preserving the continuous spectrum of the field, such as an infinite perfectly conducting plate. Using an appropriate Bogoliubov-type transformation we can diagonalize exactly the Hamiltonian of our system in the continuum limit and obtain non-perturbative expressions for its ground-state energy. From the expressions found, the atom-wall Casimir-Polder interaction energy can be obtained, and well-know lowest-order results are recovered as a limiting case. Use and advantage of this method for dealing with other systems where perturbation theory …
Effects of initialization on response of a fully-distributed hydrologic model
2008
Summary Knowledge of initial conditions is very important to correctly model the basin response at the storm event scale. Of particular interest is the influence of topography and soil type on the principal hydrologic variables and runoff generation mechanisms as a function of antecedent wetness conditions. This study addresses the influence of initial states on the short-term hydrologic response and characterizes the effects of topography and soils on the dissipation of the influence of the initialization conditions. Two case studies are considered: a synthetic two-dimensional planar hillslope with various assumed slope magnitudes and soil types; and a real basin (∼800 km2) with actual lan…
Fitness costs of intrinsic competition in two egg parasitoids of a true bug
2015
Intrinsic competition in insect parasitoids occurs when supernumerary larvae develop in the same host as consequence of multiple ovipositions by females of the same species (intra-specific competition) or by females of different species (inter-specific competition). Studies on intrinsic competition have mainly focused on understanding the factors that play a role in the outcome of competition, while fitness-related effects for the parasitoid surviving the competition have been poorly investigated, especially in egg parasitoids. Interestingly, even the winning parasitoid can experience fitness costs due to larval development in a host in which multiple factors have been injected by the ovipo…
Virgins in the wild: mating status affects the behavior of a parasitoid foraging in the field
2008
In haplodiploid organisms, virgin females can produce offspring, albeit only sons. They may therefore face a trade-off between either: (1) searching for hosts and producing sons immediately; or (2) searching for mates and perhaps producing both sons and daughters later in life. Although this trade-off raises a theoretical interest, it has not been approached experimentally. The objective of this article is thus to document the effect of mating status on the foraging behavior of a haplodiploid parasitoid. For this, we recorded the behavior of virgin and mated female Lysiphlebus testaceipes (Hymenoptera: Braconidae) after being released, in the field, on a colony of their aphid hosts. Half of…
Two-color ionization of hydrogen by short intense pulses
2010
Photoelectron energy spectra resulting by the interaction of hydrogen with two short pulses having carrier frequencies, respectively, in the range of the infrared and XUV regions have been calculated. The effects of the pulse duration and timing of the X-ray pulse on the photoelectron energy spectra are discussed. Analysis of the spectra obtained for very long pulses show that certain features may be explained in terms of quantum interferences in the time domain. It is found that, depending on the duration of the X-ray pulse, ripples in the energy spectra separated by the infrared photon energy may appear. Moreover, the temporal shape of the low frequency radiation field may be inferred by …