Search results for "INTERFACE"
showing 10 items of 2139 documents
Label-free histamine detection with nanofluidic diodes through metal ion displacement mechanism
2017
[EN] We design and characterize a nanofluidic device for the label-free specific detection of histamine neurotransmitter based on a metal ion displacement mechanism. The sensor consists of an asymmetric polymer nanopore fabricated via ion track-etching technique. The nanopore sensor surface having metal-nitrilotriacetic (NTA-Ni2+) chelates is obtained by covalent coupling of native carboxylic acid groups with N-alpha,N-alpha-bis(carboxymethyl)-L-lysine (BCML), followed by exposure to Ni2+ ion solution. The BCML immobilization and subsequent Ni2+ ion complexation with NTA moieties change the surface charge concentration, which has a significant impact on the current-voltage (I-V) curve after…
Wormlike Polystyrene Brushes in Thin Films
1997
Mono- and multilayer films were prepared on mica by solution casting of a high molecular weight polymacromonomer, i.e., a polymethacrylate of about 1000 repeating units each of which was substituted by a polystyrene chain with a molecular weight of about 5000 Da. The films were studied by tapping scanning force microscopy. The material showed a remarkable preference for forming well-defined monolayers of a thickness of 6.5 ± 0.2 nm consistent with the hard core diameter of the collapsed cylindrical brush molecules. When the films were probed with high normal force, the single molecules were observed to organize in a dense nematic-like packing as expected for inherently stiff molecules. In o…
BANΔIT: B’‐factor Analysis for Drug Design and Structural Biology
2020
The analysis of B‐factor profiles from X‐ray protein structures can be utilized for structure‐based drug design since protein mobility changes have been associated with the quality of protein‐ligand interactions. With the BANΔIT (B’‐factor analysis and ΔB’ interpretation toolkit), we have developed a JavaScript‐based browser application that provides a graphical user interface for the normalization and analysis of B’‐factor profiles. To emphasize the usability for rational drug design applications, we have analyzed a selection of crystallographic protein‐ligand complexes and have given exemplary conclusions for further drug optimization including the development of a B’‐factor‐supported pha…
Multiple register synchronization with a high-speed serial link using the Aurora protocol
2013
In this work, the development and characterization of a multiple synchronous registers interface communicating with a high-speed serial link and using the Aurora protocol is presented. A detailed description of the developing process and the characterization methods and hardware test benches are also included. This interface will implement the slow control busses of the digitizer cards for the second generation of electronics for the Advanced GAmma Tracking Array (AGATA).
A Portable Readout System for Microstrip Silicon Sensors (ALIBAVA)
2009
A readout system for microstrip silicon sensors has been developed. This system is able to measure the collected charge in one or two microstrip silicon sensors by reading out all the channels of the sensor(s), up to 256. The system can operate either with non-irradiated and irradiated sensors as well as with n-type and p-type microstrip silicon sensors. Heavily irradiated sensors will be used at the Super Large Hadron Collider, so this system can be used to research the performance of microstrip silicon sensors in conditions as similar as possible to the Super Large Hadron Collider operating conditions. The system has two main parts: a hardware part and a software part. The hardware part a…
Effect of ion irradiation on the stability of amorphous Ge2Sb2Te5 thin films
2008
The archival life of phase-change memories (PCM) is determined by the thermal stability of amorphous phase in a crystalline matrix. In this paper, we report the effect of ion beam irradiation on the crystallization kinetics of amorphous Ge2Sb2Te5 alloy (GST). The transition rate of amorphous GST films was measured by in situ time resolved reflectivity (TRR). The amorphous to crystal transformation time decreases considerably in irradiated amorphous GST samples when ion fluence increases. The stability of amorphous Ge2Sb2Te5 thin films subjected to ion irradiation is discussed in terms of the free energy variation of the amorphous state because of damage accumulation. © 2008 Elsevier B.V. Al…
Effect of double frequency heating on the lead afterglow beam currents of an electron cyclotron resonance ion source
2017
International audience; The effect of double frequency heating on the performance of the CERN GTS-LHC 14.5 GHz ElectronCyclotron Resonance (ECR) ion source in afterglow mode is reported. The source of the secondary microwave frequency was operated both in pulsed and continuous wave (CW) modes within the range of 12–18 GHz. The results demonstrate that the addition of the secondary frequency can significantly impact the extracted beam currents and the temporal stability of the beam during the afterglow discharge. For example, up to a factor of 2.6 increase was achieved for 208Pb35+ and a factor of 3.1 for 208Pb37+ compared to single frequency afterglow currents. It is shown that these effect…
Vacuum electrical breakdown conditioning study in a parallel plate electrode pulsed dc system
2019
Conditioning of a metal structure in a high-voltage system is the progressive development of resistance to vacuum arcing over the operational life of the system. This is, for instance, seen during the initial operation of radio frequency (rf) cavities in particle accelerators. It is a relevant topic for any technology where breakdown limits performance and where conditioning continues for a significant duration of system run time. Projected future linear accelerators require structures with accelerating gradients of up to 100 MV/m. Currently, this performance level is achievable only after a multimonth conditioning period. In this work, a pulsed dc system applying voltage pulses over paral…
Diagnostics of a charge breeder electron cyclotron resonance ion source helium plasma with the injection ofNa231+ions
2016
This work describes the utilization of an injected 23Na1+ ion beam as a diagnostics of the helium plasma of a charge breeder electron cyclotron resonance ion source. The obtained data allows estimating the upper limit for the ion-ion collision mean-free path of the incident sodium ions, the lower limit of ion-ion collision frequencies for all charge states of the sodium ions and the lower limit of the helium plasma density. The ion-ion collision frequencies of high charge state ions are shown to be at least on the order of 1–10 MHz and the plasma density is estimated to be on the order of 1011 cm−3 or higher. The experimental results are compared to simulations of the 23Na1+ capture into t…
Toroidal magnetized iron neutrino detector for a neutrino factory
2013
A neutrino factory has unparalleled physics reach for the discovery and measurement of CP violation in the neutrino sector. A far detector for a neutrino factory must have good charge identification with excellent background rejection and a large mass. An elegant solution is to construct a magnetized iron neutrino detector (MIND) along the lines of MINOS, where iron plates provide a toroidal magnetic field and scintillator planes provide 3D space points. In this paper, the current status of a simulation of a toroidal MIND for a neutrino factory is discussed in light of the recent measurements of large theta(13). The response and performance using the 10 GeV neutrino factory configuration ar…