Search results for "INU"

Yhteisön muisteltu muutos

2010

Tutkielman kohteena on Kainuussa sijaitsevan Paltamon kahdentoista rantakylän muisteltu muutos 1940–1960-lukujen välisellä ajalla nuottakalastuksen kautta tarkasteltuna. Tutkimuksen tieteenfilosofinen pohja on sosiaalinen konstruktivismi. Pääajatuksena on, että muistelu on sosiaalisesti ja kulttuurisesti tuotettua. Tutkimusmenetelmäni on muisteluaineiston kvalitatiivinen analyysi. Aineisto on osa keräämääni Nuotta-apajilla -haastatteluaineistoa, käytän aineistosta 26:n informantin haastatteluja. Keskeiset käsitteet ovat muistelu, yhteisö, sekä kulttuurinen mallitarina. Kysyn, miten haastateltavat muistavat kyläyhteisönsä muutoksen 1940–1960-luvuilla nuottakalastuksen työmuodon kautta. Tarka…

Kaukana Kainuussa, valtaväylän varrella : etnologinen tutkimus Kontiomäen rautatieläisyhteisön elinkaaresta 1950-1972

2004

FL Kimmo Lagerblomin etnologian väitöskirjan ”Kaukana Kainuussa, valtaväylän varrella. Etnologinen elinkaaritutkimus Kontiomäen rautatieläisyhteisöstä vuosina 1950-1973.” tarkastustilaisuus. Vastaväittäjänä professori Pekka Leimu (Turun yliopisto) ja kustoksena professori Bo Lönnqvist.Kimmo Lagerblomin tutkimus on ensimmäinen Suomessa tehty väitöskirja, jonka painopiste on rautatieläiskulttuurissa. Kontiomäen lisäksi tutkimuksessa tarkastellaan laajemminkin rautatien historiallista merkitystä sekä Suomessa että muualla. This study is located on Kontiomäki railtown; witch is a small village some 600 kilometres north from Helsinki. Kontiomäki is a typical railtown. The Finnish State Railway C…

One-dimensional compression and consolidation of shales

2016

This paper presents a comprehensive methodology for analysing the compression and consolidation behaviour of shales. An apparatus was designed to perform oedometric high-pressure tests by applying a maximum vertical total stress of 100 MPa and simultaneously controlling the pore water pressure of the specimen. An analytical method was formulated to analyse the shale consolidation behaviour, which allows information to be gathered on the coefficient of consolidation, stiffness, poroelastic properties, secondary compression and permeability of the tested material as a function of the applied stress conditions. Results obtained on Opalinus Clay shale using the developed methodology are present…

Synthesis, characterization, and cytotoxic activity of copper(II) and platinum(II) complexes of 2-benzoylpyrrole and X-ray structure of bis[2-benzoyl…

2004

Copper(II) and platinum(II) complexes of 2-benzoylpyrrole (2-BZPH) were synthesized and characterized with IR, 1 H and 1 3 C NMR spectroscopies and coordination geometry with ligands arranged in transoid fashion. The crystal structure of [Cu I I (2-BZP) 2 ] was determined by X-ray diffraction. Death of complex treated Jurkat cells was measured by flow cytometry. The bis-chelate complexes [Cu I I (2-BZP) 2 ] and [Pt I I (2-BZP) 2 ] adopt square-planar coordination geometry with ligands, arranged in transoid fashion. Concentrations of 1-10 μM Platinum(II) complexes reduced cell survival from 100% to 20%, in contrast to the copper(II) complex which caused no cell death at a concentration of 10…

2019

Global changes promote the spread of infectious diseases worldwide. In this context, tropical urogenital schistosomiasis is now permanently established in Corsica since its first emergence in 2013. The local persistence of the tropical pathogens (schistosomes) responsible for urogenital schistosomiasis at such latitudes might be explained by (i) the presence of its intermediate host, the snail Bulinus truncatus, (ii) the recurrent local reseeding of schistosomes by their vertebrate hosts (either human or animal) every summer, and/or (iii) the maintenance and survival of schistosomes within their snail hosts over winter. In this study we conducted an ecological experiment to assess the abili…

Climatic gradients along the windward slopes of Mount Kenya and their implication for crop risks. Part 1: climate variability

2012

In tropical mountains, the way topographical gradients translate in terms of intra-seasonal and interannual climate variability (especially rainfall and evapotranspiration) is relatively unknown, yet it is an important issue for agriculture and food security. The eastern slopes of Mount Kenya, in East Africa, with their wide range of agro-ecological conditions, are appropriate for the study of these aspects. Daily (monthly) rainfall data from 11 (24) stations at different elevations and exposures are collected for the period 1961-2006. For the elevation belts suitable for farming and agro-pastoral activities, mostly below 2000 m, it is found that not all rainfall characteristics co-vary wit…

Smart inulin-based polycationic nanodevices for siRNA delivery

2017

The advances of short interfering RNA (siRNA) mediated therapy provide a powerful option for the treatment of many diseases by silencing the expression of targeted genes including cancer development and progression. Inulin is a very simple and biocompatible polysaccharide proposed by our groups to produce interesting delivery systems for Nucleic Acid Based Drugs (NABDs), such as siRNA, either as polycations able to give polyplexes and polymeric coatings for nanosystems having a metallic core. In this research field, different functionalizing groups were linked to the inulin backbone with specific aims including oligoamine such as Ethylendiammine (EDA), Diethylediamine (DETA), Spermine, (SPM…

Development of a simple, biocompatible and cost-effective Inulin-Diethylenetriamine based siRNA delivery system

2015

Small interfering RNAs (siRNAs) have the potential to be of therapeutic value for many human diseases. So far, however, a serious obstacle to their therapeutic use is represented by the absence of appropriate delivery systems able to protect them from degradation and to allow an efficient cellular uptake. In this work we developed a siRNA delivery system based on inulin (Inu), an abundant and natural polysaccharide. Inu was functionalized via the conjugation with diethylenetriamine (DETA) residues to form the complex Inu-DETA. We studied the size, surface charge and the shape of the Inu-DETA/siRNA complexes; additionally, the cytotoxicity, the silencing efficacy and the cell uptake-mechanis…

Duality of moduli in regular toroidal metric spaces

2020

We generalize a result of Freedman and He [4, Theorem 2.5], concerning the duality of moduli and capacities in solid tori, to sufficiently regular metric spaces. This is a continuation of the work of the author and Rajala [12] on the corresponding duality in condensers. peerReviewed

Real-time simulation of tissue deformation for the nasal endoscopy simulator (NES).

1999

Endonasal sinus surgery requires a great amount of training before it can be adequately performed. The complicated anatomy involved, the proximity of relevant structures, and the variability of the anatomy due to inborn or iatrogenic variations make several complications possible. Today, cadaver dissections are the "gold standard" for surgical training. To overcome the drawbacks of traditional training methods, the Fraunhofer Institute for Computer Graphics is currently developing a highly interactive medical simulation system for nasal endoscopy and endonasal sinus surgery, in cooperation with the Mainz University Hospital. For the simulation of a rhinoscopic procedure, not only are the re…