Search results for "INU"
showing 10 items of 5427 documents
Problemas multiplicativos relacionados con la división de fracciones : un estudio sobre su enseñanza y aprendizaje
2013
Los estudiantes tienen dificultades para asociar el enunciado de un problema multiplicativo con la operación que permite resolverlo; esta investigación identifica los tipos de problemas multiplicativos que los estudiantes reconocen como de división de fracciones. Mediante el análisis histórico-epistemológico de textos de enseñanza sobre tres épocas históricas y ocho períodos diferentes, se obtiene un listado de variables de enseñanza (algoritmos, sentidos de uso de fracción y de división de fracciones, representaciones, problemas), así como los valores de dichas variables. Se localizan en los textos consultados algunas reglas particulares y seis algoritmos generales, cuyo predominio ha vari…
Inventario y descripción de las soluciones de accesibilidad a la web existentes para personas con discapacidad fisica y sensorial
2011
El elemento más representativo de la nueva sociedad de la información lo constituye sin duda la World Wide Web. La Red, como es conocida popularmente, une a millones de ordenadores en todo el mundo, aportando una riqueza de información inimaginable hace pocos años y un interfaz de uso tan gráfico e intuitivo que ha significado una expansión permanente de su uso a millones de usuarios nuevos cada año. La accesibilidad Web se puede definir como la posibilidad de que un producto o servicio Web sea usado por el mayor número posible de personas, independientemente de las limitaciones del individuo o de las del contexto de uso. De acuerdo con el Tratado de Amsterdam de la Unión Europea, en aplica…
Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation and Study of Diabetic Nephropathy with Atrasentan : what …
2019
Albuminuria; Atrasentan; Canagliflozin Albuminuria; Atrasentan; Canagliflozina Albuminúria; Atrasentan; Canagliflozina In April 2019, two major Phase 3 randomized clinical trials were published that assessed primary renal outcomes in diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM). The Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) tested an already available antidiabetic drug, canagliflozin, and the Study of Diabetic Nephropathy with Atrasentan (SONAR) tested a novel molecule, the endothelin-1 receptor blocker atrasentan, both on top of renin-angiotensin system blockade. Both trials demonstrated significant nephroprot…
In Silico Conformational Features of Botulinum Toxins A1 and E1 According to Intraluminal Acidification
2022
International audience; Although botulinum neurotoxins (BoNTs) are among the most toxic compounds found in nature, their molecular mechanism of action is far from being elucidated. A key event is the conformational transition due to acidification of the interior of synaptic vesicles, leading to translocation of the BoNT catalytic domain into the neuronal cytosol. To investigate these conformational variations, homology modeling and atomistic simulations are combined to explore the internal dynamics of the sub-types BoNT/A1 (the most-used sub-type in medical applications) and BoNT/E1 (the most kinetically efficient sub-type). This first simulation study of di-chain BoNTs in closed and open s…
Effects of Long-Term Habitat Protection on Montane Small Mammals: Are Sorex araneus and S. minutus More Sensitive Than Previously Considered?
2022
Protection of natural areas by restricting human activities aims to preserve plant and animal populations and whole communities, ensuring the conservation of biological diversity and enhancement of ecosystem services. Therefore, it is expected that the longer the protection, the stronger the desired effects. We evaluated the responses of small mammals at the population and community levels under protection in the southern Carpathian Mountains. We surveyed small mammals for five years in sites with long- and short-term protection and non-protected. Besides protection status, we included elevation, habitat heterogeneity, and the month of survey as predictors in our models. As response variabl…
Genesi geometrica delle volte centriche
1996
Un'analisi completa degli organismi voltati comporta lo studio delle molteplici componenti necessarie alla loro definizione: configurazione geometrica, sistema costruttivo, area storico-geografica di appartenenza, interpretazioni Stilistiche. L’obiettivo di questo studio è indirizzato all' analisi delle volte continue su pianta centrica definibili attraverso le leggi della geometria euclidea. L’indagine si pone all'interno dei confini relativi alla loro configurazione geometrica e il criterio adottato, svincolato da classificazioni di carattere tipologico o stilistico, propone l'identificazione di famiglie geometriche in base alla figura del poligono di base dell'impianto. Si può identifica…
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…
Atrian natriuretic peptide (ANP)-Presence in human inferior turbinate after botulism toxin type A treatment
2012
Studies demomstrated the ANP-presence in the mucosa of human turbinate, the study aimed to investigate about the ANP-presence of human turbinates of patients after treatment with the Botulinum Toxyn-A(BTX-A) since no data are reported. Results show that in BTX-A treated patients ANP is present in the ciliated and basal cells of the epithelium of tonaca mucosa and some glands;therefore ANP-presence is more intense than in mucosa of untreated patients.
Coronavirus Disease 2019–Associated Coagulopathy
2021
Patients with the severe form of coronavirus disease 2019 (COVID-19) have been frequently found to suffer from both arterial and venous thrombotic events due to the perpetuation of a hypercoagulable state. This phenomenon, termed COVID-19-associated coagulopathy (CC), is now considered a major component of the pathophysiology of this novel infectious disease, leading to widespread thrombosis. While at first, the vascular insults may be limited to the pulmonary microvasculature, as the disease progresses, systemic involvement occurs, culminating in distant organ thrombosis and multi-organ dysfunction syndrome. In this review article, we discuss recent insights into the pathophysiologic mecha…
Quantification of atelectatic lung volumes in two different porcine models of ARDS.
2006
BACKGROUND: Cyclic recruitment during mechanical ventilation contributes to ventilator associated lung injury. Two different pathomechanisms in acute respiratory distress syndrome (ARDS) are currently discussed: alveolar collapse vs persistent flooding of small airways and alveoli. We compare two different ARDS animal models by computed tomography (CT) to describe different recruitment and derecruitment mechanisms at different airway pressures: (i) lavage-ARDS, favouring alveolar collapse by surfactant depletion; and (ii) oleic acid ARDS, favouring alveolar flooding by capillary leakage. METHODS: In 12 pigs [25 (1) kg], ARDS was randomly induced, either by saline lung lavage or oleic acid (…