Search results for "INVESTIGATION"
showing 10 items of 366 documents
Scientific investigation to preserve our architectural heritage: experimental application in Sicily between 2002 and 2012
2014
The essay introduces the result of thermographic surveys and other scientific applications on some Sicilian monuments, and demonstrates the clear evolution of the method to support an effective conservation of ancient buildings. The method introduced is useful to get a metric thermal image to be edited with the photogrammetric image of the architectural surfaces simultaneously, and related with the results of other kind of diagnostic tests. Some examples of its application are introduced and critically commented to understand all the potentialities of the investigation in the discipline of the restoration of cultural heritage.
Propositions pour une littérature d'investigation
2017
International audience; Le temps semble à l’alliance de la littérature et des sciences sociales. Mais les modalités en sont encore incertaines. Au lieu de considérer l’anthropologie comme une forme de littérature, on peut envisager la littérature comme une enquête. Cette « littérature d’investigation » se donne notamment pour objectif de documenter des formes de vie et de monter des dispositifs rendant compte d’aspects inaperçus de phénomènes sociaux. Elle occupe ainsi une position intermédiaire : elle se ménage à la fois une liberté et une créativité relatives vis-à-vis des protocoles d’enquête propres aux sciences sociales et une certaine méfiance pour un sens trop révérencieux envers la …
Lucian, a new Odysseus? : role and issue of a Homeric character in the work of Lucian of Samosata
2015
The aim of our thesis, which comes within the scope of considering the process of rewriting classic texts in the time period of the second sophistic, is to study the unique importance of Odysseus in the writings of Lucian of Samosata. At first, Odysseus is distinguished from Achilles, a character more monolithic who, even in Homer’s works is constructed in contrast to Odysseus. Moreover, from an isolated quote to intricate references, scattered to create echoes between works seemingly very different, the context in which Odysseus appears is more elaborate and subtler than that of Achilles. Hence, studying and comparing references to both heroes is sufficient to imply Odysseus’ primacy, asso…
Post-fotografia etnografica
2021
È evidente come la nostra società tecnologica sia legata senza alcun dubbio alla diffusione delle immagini. Autori come Gottfried Boehm, John Mitchell, Hans Belting hanno indagato la natura dell'immagine ponendo le basi, negli anni Novanta, per l'idea di un pictorial turn, di una cultura totalmente dominata dalle immagini che è diventata adesso una possibilità tecnica reale su scala globale. Un nuovo statuto dell'immagine che si usa raccogliere sotto l'etichetta di iconic turner inserito nel più vasto campo visual culture studies. L'uso del termine cultura accanto a quello di visuale è indicativo dell'ampiezza del campo d'indagine che visual culture studies si prefiggono di ricercare: essi …
An unprecedented hetero-bimetallic three-dimensional spin crossover coordination polymer based on the tetrahedral [Hg(SeCN)4]2− building block
2019
[EN] Self-assembly of octahedral FeII ions, trans-1,2-bis(4-pyridyl) ethane (bpe) bridging ligands and [Hg(XCN)(4)](2-) (X = S (1), Se (2)) tetrahedral building blocks has afforded a new type of hetero-bimetallic Hg-II-Fe-II spin-crossover (SCO) 3D 6,4-connected coordination polymer (CP) formulated {Fe(bpe)[Hg(XCN)(4)]}(n). For X = S (1), the ligand field is close to the crossing point but 1 remains paramagnetic over all temperatures. In contrast, for X = Se (2) the complex undergoes complete thermal induced SCO behaviour centred at T-1/2 = 107.8 K and complete photoconversion of the low spin state into a metastable high-spin state (LIESST effect) with T-LIESST = 66.7 K. The current results…
Photosensitive Alternative Splicing of the Circadian Clock Gene timeless Is Population Specific in a Cold-Adapted Fly, Drosophila montana.
2018
To function properly, organisms must adjust their physiology, behavior and metabolism in response to a suite of varying environmental conditions. One of the central regulators of these changes is organisms' internal circadian clock, and recent evidence has suggested that the clock genes are also important in the regulation of seasonal adjustments. In particular, thermosensitive splicing of the core clock gene <i>timeless</i> in a cosmopolitan fly, <i>Drosophila melanogaster</i> , has implicated this gene to be involved in thermal adaptation. To further investigate this link we examined the splicing of <i>timeless</i> in a northern malt fly species, <i&…
Developing creativity through ICT and Music Teachers’ Training: a biographical experience
2021
O texto faz parte de uma investigação qualitativa biográfico-narrativa que temos em curso, e que se processa mediante a obtenção de testemunhos de professores e investigadores que formam professores com o auxílio das TIC de modo a promover as competências de criatividade, colaboração, cooperação e comunicação, entendidas como essenciais para o desenvolvimento de uma educação integral, promotora da sustentabilidade curricular e da cidadania participativa. Neste artigo, damos conta da experiência de uma professora e investigadora, Cristina Arriaga Sanz, que se dedica à formação de professores no âmbito da Educação Musical no ensino superior espanhol, de que salientaremos a relação estreita co…
Effect of pharmacological interventions and placebo on liver Histology in nonalcoholic steatohepatitis: A network meta-analysis
2022
Background: The aims of this study were to quantify the histological improvement and its risk factors in patients with NASH enrolled in the placebo arms of randomized controlled trials (RCTs), and to indirectly compare the effect of several investigational drugs for NASH on validated histological outcomes.Data synthesis: A comprehensive search was conducted to detect phase 2 and 3 RCTs comparing pharmacological interventions in patients with NASH. According to Food and Drug Administra-tion (FDA) recommendations, primary outcomes included: 1) NASH resolution without wors-ening of fibrosis; 2) At least 1-point reduction in fibrosis without worsening of NASH. Meta -analysis and meta-regression…
Emerging MEK inhibitors
2010
IMPORTANCE OF THE FIELD: The Ras/Raf/MEK/ERK pathway is often activated by genetic alterations in upstream signaling molecules. Integral components of this pathway such as Ras and B-Raf are also activated by mutation. The Ras/Raf/MEK/ERK pathway has profound effects on proliferative, apoptotic and differentiation pathways. This pathway can often be effectively silenced by MEK inhibitors. AREAS COVERED BY THIS REVIEW: This review will discuss targeting of MEK which could lead to novel methods to control abnormal proliferation which arises in cancer and other proliferative diseases. This review will cover the scientific literature from 1980 to present and is a follow on from a review which fo…
Inferring heterozygosity from ancient and low coverage genomes
2016
Abstract While genetic diversity can be quantified accurately from high coverage sequencing data, it is often desirable to obtain such estimates from data with low coverage, either to save costs or because of low DNA quality, as is observed for ancient samples. Here, we introduce a method to accurately infer heterozygosity probabilistically from sequences with average coverage &lt;1× of a single individual. The method relaxes the infinite sites assumption of previous methods, does not require a reference sequence, except for the initial alignment of the sequencing data, and takes into account both variable sequencing errors and potential postmortem damage. It is thus also applicable to …