Search results for "IONT"

Enhancement of nortriptyline penetration through human epidermis: influence of chemical enhancers and iontophoresis.

2008

Abstract Different known percutaneous chemical enhancers and iontophoresis have been tested in-vitro to study their ability to increase transdermal absorption of nortriptyline hydrochloride (20 mg mL−1). The chemicals 1-dodecanol, Span 20, Azone, (R)-(+)-limonene or isopropyl myristate were used as an overnight pretreatment at 5% (w/w) in ethanol. Furthermore, isopropyl myristate (20%, w/w) and propylene glycol (15%, w/w) were tested in the same vehicle. Iontophoresis was applied directly to the nortriptyline hydrochloride donor solution for three different concentrations (20, 2 and 0.5 mgmL−1). The chemical enhancers slightly increased the nortriptyline transdermal flux but iontophoresis w…

Unit study in cat claustrum of the effects of iontophoretic neurotransmitters and correlations with the effects of activation of some afferent pathwa…

1982

Glutamate (Glut), acetylcholine (ACh) and dopamine (DA) were iontophoretically applied on cat claustral neurons. Glut did not affect all the neurons; ACh had both excitatory and inhibitory effects, while DA was prevalently inhibitory. An analysis was made of the time-course of excitatory and inhibitory responses on the basis of the mean firing rate variations during and after ACh and DA release. Three types of responses are described for each drug: short lasting inhibition, long lasting inhibition and long lasting excitation. The experimental data were statistically elaborated. The effects of ACh and of DA were compared with those of activation obtained by sensorial peripheric and thalamic …

On Combinatorial Generation of Prefix Normal Words

2014

A prefix normal word is a binary word with the property that no substring has more 1s than the prefix of the same length. This class of words is important in the context of binary jumbled pattern matching. In this paper we present an efficient algorithm for exhaustively listing the prefix normal words with a fixed length. The algorithm is based on the fact that the language of prefix normal words is a bubble language, a class of binary languages with the property that, for any word w in the language, exchanging the first occurrence of 01 by 10 in w results in another word in the language. We prove that each prefix normal word is produced in O(n) amortized time, and conjecture, based on expe…

Noninvasive sampling of phenylalanine by reverse iontophoresis.

1999

While iontophoresis is typically associated with drug delivery across the skin, the symmetry of the technique permits its application to the essentially noninvasive withdrawal of biologically important analytes from the subcutaneous space to the body's surface. The identification of other substances which can be monitored by this procedure, and to its optimization and development as a more general clinical chemistry tool, is a long-term objective. In this paper, we describe a preliminary in vitro investigation into the feasibility of extracting and analyzing the amino acid, phenylalanine, with the ultimate aim to develop a diagnostic test for phenylketonuria, a potentially fatal metabolic d…

Présence d’Asellides stygobies (Crustacea, Isopoda, Aselloidea) dans la région du Primorye, Sibérie sud-orientale

1993

Two species of anophthalmous, unpigmentedasellids have been found in springs and groundwaters of S.E. Siberia (Primorye region). Asellus (Asellus) primoryensis n. sp. is closelyrelated to the epigean species A. (A.) hilgendorfii Bovallius, 1886, as is the case for all stygobiont Asellus (Asellus) species previously known from the Japanese archipelago. Sibirasellus parpurae n. g., n. sp. is closely related to the microphthalmous species Asellus dentifer Birstein & Levanidov, 1952 from the Ussuri Basin (Khor region), now type-species of the new genus Sibirasellus. These two species show several original characters: body covered by numerous cuticular squamulae, mandibular palp reduced (gla…

Electrophysiological and microiontophoretic analysis of the habenulo-hippocampal circuit.

1991

In the cat, the effects of lateral habenula stimulation, at different ranges of frequency, on hippocampal units were studied. Habenular stimulation at low frequency excited, while at high frequency inhibited the greater part of hippocampal units. Moreover, in order to clarify the possible pathway involved in the habenulo-hippocampal circuit, the effects of iontophoretic acetylcholine and serotonin on hippocampal units were compared with those of habenular stimulation. Iontophoretic acetylcholine induced both excitatory and inhibitory responses while serotonin induced only inhibitory responses. Iontophoretic atropine blocked the effects of acetylcholine ejection but did not antagonize stimul…

Adaptive Attitude Control of a Rigid Body with Input and Output Quantization

2022

Author's accepted manuscript. © 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. In this paper, the adaptive attitude tracking the problem of a rigid body is investigated where the input and output are transmitted via a network. To reduce the communication burden in a network, a quantizer is introduced in both uplink and downlink communication channels. An adaptiv…

A Two-Dimensional Autoregressive Model for MIMO Wideband Mobile Radio Channels

2008

In this work, we propose the multichannel two- dimensional (2D) autoregressive (AR) model for multiple-input multiple-output (MIMO) wideband mobile wireless channels. The parameters of the proposed model can be estimated from the real- world measurement data. For this purpose, we suggest using a straightforward extension of the prediction error minimization (PEM) algorithm. We also address the problem of possible instability of the multichannel 2D AR model. A model stabilization procedure based on numerical optimization techniques is proposed. The performance of the multichannel 2D AR model has been evaluated based on the synthetic data generated using two different channel simulators.

Spatial distribution and aggregation ofXenobalanus globicipitison the flukes of striped dolphins,Stenella coeruleoalba: An indicator of host hydrodyn…

2020

Optimal Relays Deployment for 802.16j Networks

2012

In this paper, we consider optimal relay station deployment for the IEEE 802.16j networks. IEEE 802.16j is an emerging wireless broadband networking standard that integrates infrastructure base stations with multihop relay technology. The proposed relay deployment mechanism allows us to maximize network capacity for every user or to maximize total network capacity, and, therefore, to reach greater network capacity values while employing smaller number of relay stations. With the proposed approach, the necessary number of relays for a region can be found.