Search results for "IPF"
showing 10 items of 16 documents
Numerical Analysis of Word Frequencies in Artificial and Natural Language Texts
1997
We perform a numerical study of the statistical properties of natural texts written in English and of two types of artificial texts. As statistical tools we use the conventional Zipf analysis of the distribution of words and the inverse Zipf analysis of the distribution of frequencies of words, the analysis of vocabulary growth, the Shannon entropy and a quantity which is a nonlinear function of frequencies of words, the frequency "entropy". Our numerical results, obtained by investigation of eight complete books and sixteen related artificial texts, suggest that, among these analyses, the analysis of vocabulary growth shows the most striking difference between natural and artificial texts…
Subtitling and dubbing as teaching resources for learning English as a foreign language using Clipflair software
2020
[EN] The research validity of using clips as audiovisual material to teach a foreign language has been demonstrated by many scholars. At the same time, the combination of this material with two modalities of audiovisual translation (AVT) - subtitling and dubbing- is worth exploring. The aim of this study is to present the effectiveness of subtitling and dubbing activities as tools for teaching English as a foreign language. In order to do so, a number of participants from the University of Valencia (Spain) whose level of English was B2/B2+ were engaged in a combination of subtitling and dubbing activities. I devised a series of tasks based on a two-minute subtitled video-clip, designed to i…
Zipf’s Law and World Income Distribution
2008
The aim of this article is to demonstrate regularity in the world income distribution. In particular, using GDP per capita data for the period 1980 to 2004, the article shows that the world income distribution follows the well know 'rank-size rule'.
Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis
2022
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by an abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis within the alveolar wall that are not due to infection or cancer. Oxidative stress has been proposed as a key molecular process in pulmonary fibrosis development and different components of the redox system are altered in the cellular actors participating in lung fibrosis. To this respect, several activators of the antioxidant machinery and inhibitors of the oxidant species and pathways have been assayed in preclinicalin vitroandin vivomodels and in different clinical trials. This review discusses the role of …
The impact of SARS-COV2 pandemic on the management oF IPF patients: Our narrative experience
2021
Abstract Background The SARS-CoV-2 pandemic has changed the health-care systems around the world in a remarkable way. We describe the strategies adopted to cope with the limitations imposed by the pandemic to the access to health care by patients diagnosed with idiopathic Pulmonary Fibrosis (IPF). Material and methods We conducted a retrospective observational analysis including IPF patients under antifibrotic drugs (nintedanib and pirfenidone) that accessed to the Outpatient clinic of the University of Palermo, Italy. Patients received a phone number and an email address in case of any urgency and a virtual meeting was settled up monthly. Results 40 patients (M/F: 30/10) were followed up, …
Comparison of MeSH terms and KeyWords Plus terms for more accurate classification in medical research fields. A case study in cannabis research
2021
Abstract KeyWords Plus and Medical Subject Headings (MeSH) are widely used in bibliometric studies for topic mapping. The objective of this study is to compare the two description systems in documents about cannabis research to find the concordance between systems and establish whether there is neutrality in topic mapping. A total of 25,593 articles from 1970 to 2019 were drawn from Web of Science's Core Collection and Medline and analyzed. The tidytext library, Zipf's law, topic modeling tools, the contingency coefficient, Cramer's V, and Cohen's kappa were used. The results included 10,107 MeSH terms and 28,870 KeyWords Plus terms. The Zipf distribution of the terms was different for each…
Pareto or log-normal? A recursive-truncation approach to the distribution of (all) cities
2012
Traditionally, it is assumed that the population size of cities in a country follows a Pareto distribution. This assumption is typically supported by finding evidence of Zipf's Law. Recent studies question this finding, highlighting that, while the Pareto distribution may fit reasonably well when the data is truncated at the upper tail, i.e. for the largest cities of a country, the log-normal distribution may apply when all cities are considered. Moreover, conclusions may be sensitive to the choice of a particular truncation threshold, a yet overlooked issue in the literature. In this paper, then, we reassess the city size distribution in relation to its sensitivity to the choice of truncat…
Mucins as a New Frontier in Pulmonary Fibrosis
2019
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary disease with a median survival of 3–5 years after diagnosis. Recent evidence identifies mucins as key effectors in cell growth and tissue remodeling processes compatible with the processes observed in IPF. Mucins are classified in two groups depending on whether they are secreted (secreted mucins) or tethered to cell membranes (transmembrane mucins). Secreted mucins (MUC2, MUC5AC, MUC5B, MUC6-8 and MUC19) are released to the extracellular medium and recent evidence has shown that a promoter polymorphism in the secreted mucin MUC5B is associated with IPF risk. Otherwise, transmembrane mucins (MUC1, MUC3,…
Idiopathic Pulmonary Fibrosis and Lung Cancer: Mechanisms and Molecular Targets
2019
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary disease with a median survival of 2–4 years after diagnosis. A significant number of IPF patients have risk factors, such as a history of smoking or concomitant emphysema, both of which can predispose the patient to lung cancer (LC) (mostly non-small cell lung cancer (NSCLC)). In fact, IPF itself increases the risk of LC development by 7% to 20%. In this regard, there are multiple common genetic, molecular, and cellular processes that connect lung fibrosis with LC, such as myofibroblast/mesenchymal transition, myofibroblast activation and uncontrolled proliferation, endoplasmic reticulum stress, alterat…
The 'power' of tourism in Portugal
2012
The author analyses the upper tail of the distribution of tourism supply in Portugal from 2002 to 2009, using data from the Instituto Nacional de Estatística database. Tourism supply is defined in terms of the lodging capacity of hotel establishments in about 250 tourist destinations. The paper shows that the empirical distribution of tourism supply in Portugal is heavy-tailed and consistent with a power law behaviour in its upper tail. Such behaviour seems to be stable over the years, provided that, for the time horizon covered by the data sets, the scaling parameter is always close to the value of two. The power law hypothesis is tested positively through the use of graphical and analyti…