Search results for "IPR"
showing 10 items of 1515 documents
Beclomethasone dipropionate hydrofluoroalkane for the treatment of allergic rhinitis
2016
Allergic rhinitis (AR) is a common respiratory disease, and its prevalence is increasing all over the world, both in adults and in children. Patients experience symptoms that may negatively impact on physical, social and psychological well-being. Hence, if left untreated, allergic rhinitis may significantly affect quality of life. Under current guidelines, intranasal corticosteroids are considered the most effective drugs and they are recommended as first-line therapy. Among the several corticosteroid intranasal sprays available, beclomethasone dipropionate is one of the most prescribed. Recently, new intranasal hydrofluoroalkane-propelled formulations with little or no impact on the ozone …
Ulipristal acetate versus leuprolide acetate for uterine fibroids
2012
A b s t r ac t Background The efficacy and side-effect profile of ulipristal acetate as compared with those of leuprolide acetate for the treatment of symptomatic uterine fibroids before surgery are unclear. Methods In this double-blind noninferiority trial, we randomly assigned 307 patients with symptomatic fibroids and excessive uterine bleeding to receive 3 months of daily therapy with oral ulipristal acetate (at a dose of either 5 mg or 10 mg) or once-monthly intramuscular injections of leuprolide acetate (at a dose of 3.75 mg). The primary outcome was the proportion of patients with controlled bleeding at week 13, with a prespecified noninferiority margin of −20%. Results Uterine bleed…
Cortical stimulation and reflex excitability of spinal cord neurones in man.
1995
The H reflex technique was used to evaluate the influence exerted by cortical conditioning on the excitability of the alpha-motoneurone pool and on IA interneuronal activity (reciprocal inhibition). In ten subjects at absolute rest electrical and magnetic stimulation of the motor cortex was transcranially applied during flexor carpi radialis H reflex eliciting and in conditions of reciprocal inhibition induced by radial nerve stimulation. The time courses showed that at intensities below motor threshold, electrical brain conditioning induced an increase in the amplitude of the test reflex when the cortical shock was given 4 ms after the test H reflex. On the contrary, reciprocal inhibition …
Bidirectional within- and between-person relations between physical activity and cognitive function
2022
Abstract Objectives To examine bidirectional within- and between-person relations between physical activity and cognitive function across 15 years. Methods Participants (N = 1,722, age range 40–85 years, 55% women) were drawn from the Betula prospective cohort study. We included 4 waves of data. Bivariate latent curve models with structured residuals were estimated to examine bidirectional within- and between-person relations between physical activity and cognitive function (episodic memory recall, verbal fluency, visuospatial ability). Results We observed no statistically significant bidirectional within-person relations over time. Higher levels of physical activity at baseline were relate…
The peer review game: an agent-based model of scientists facing resource constraints and institutional pressures
2018
This paper looks at peer review as a cooperation dilemma through a game-theory framework. We built an agent-based model to estimate how much the quality of peer review is influenced by different resource allocation strategies followed by scientists dealing with multiple tasks, i.e., publishing and reviewing. We assumed that scientists were sensitive to acceptance or rejection of their manuscripts and the fairness of peer review to which they were exposed before reviewing. We also assumed that they could be realistic or excessively over-confident about the quality of their manuscripts when reviewing. Furthermore, we assumed they could be sensitive to competitive pressures provided by the ins…
Induction of Mitochondrial Changes Associated with Oxidative Stress on Very Long Chain Fatty Acids (C22:0, C24:0, or C26:0)-Treated Human Neuronal Ce…
2012
In Alzheimer's disease, lipid alterations point towards peroxisomal dysfunctions. Indeed, a cortical accumulation of saturated very long chain fatty acids (VLCFAs: C22:0, C24:0, C26:0), substrates for peroxisomalβ-oxidation, has been found in Alzheimer patients. This study was realized to investigate the effects of VLCFAs at the mitochondrial level since mitochondrial dysfunctions play crucial roles in neurodegeneration. On human neuronal SK-NB-E cells treated with C22:0, C24:0, or C26:0 (0.1–20 μM; 48 h), an inhibition of cell growth and mitochondrial dysfunctions were observed by cell counting with trypan blue, MTT assay, and measurement of mitochondrial transmembrane potential (Δψm) with…
Die nächste Generation „atypischer” Antipsychotika: Der Beitrag der Positronenemissionstomographie
2003
Almost fifteen years of research with Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) have led to a profound understanding of the relationships between antipsychotic doses and plasma levels on the one hand and occupancy of (striatal) D 2 -like dopamine receptors on the other hand as well as with the associated clinical effects and side effects. Furthermore, with the development of clinically atypical" antipsychotics PET studies helped to generate hypotheses regarding the essential pharmacological properties of this heterogeneous class of drugs. Possible mechanisms of action include combined D 2 -/5-HT 2 antagonism, preferential mesolimbic binding, a…
The effects of personality, risk and other-regarding attitudes on trust and reciprocity
2022
Abstract This paper reports experimental results on the determinants of trust and reciprocity in the context of a genuinely sequential, binary Trust Game. Apart from behavior in the main experiment, subjects’ risk attitudes and inequality aversion are elicited, as well as the traits of neuroticism and agreeableness, captured through the five-factor model. The findings suggest that trustors’ (first movers) behavior is affected by their loss aversion, while trustees’ (second movers) reciprocal behavior is not explained by any of their other-regarding attitudes, but, rather, by their agreeableness.
DETECCIÓN DE MEDICAMENTOS EN ALIMENTOS CON LA AYUDA DE IMANES
2021
Resumen de la publicación de una participación en formato µVídeo en en el congreso Divulga NextGen (1ª edición) que se celebrará online, de manera gratuita y en las redes sociales los días 26, 27 y 28 de mayo de 2021
Periodic Polynomial Splines
2018
In this chapter, the spaces of periodic polynomial splines and the Spline Harmonic Analysis (SHA) in these spaces are briefly outlined. The stuff of this chapter is used for the design of periodic discrete-time splines and discrete-time-spline-based wavelets and wavelet packets. For a detailed description of the subject we refer to (Averbuch, Neittaanmaki and Zheludev, Spline and Spline Wavelet Methods with Applications to Signal and Image Processing, Springer, Berlin, 2014) [1]. Periodic polynomial splines provide an example of mixed discrete-continuous circular convolution.