Search results for "IPR"
showing 10 items of 1515 documents
Athènes et les « Philaïdes » Formes de réciprocité entre les aristocrates et la polis
2009
This article aims at exploring the relationship between Athens and the members of the Miltiades and Cimon family, the so-called Philaids. The history of this lineage significantly marked the development of Athens in the archaic period. In spite of the contradictory traditions regarding these historical figures, a lexical analysis of the sources allows an interpretation of their relationship with the polis in terms of reciprocity. I will argue that this is a special form of reciprocity, generated by the unequal and asymmetric relationship that this family seems to have had with Athens.
Family Reciprocity and Caring Relationships in Ageing Societies
2010
Clinical correlates of paliperidone palmitate and aripiprazole monohydrate prescription for subjects with schizophreniaspectrum disorders: Findings f…
2020
This study, based on the 'Servizi Territoriali Associati per la Ricerca' (STAR) Network Depot Study nationwide baseline data, explored whether individual symptoms severity and clusters might influence the prescription of paliperidone palmitate 1-month (PP1M) vs. aripiprazole monohydrate. The Brief Psychiatric Rating Scale (BPRS) was used to assess psychopathology and relevant symptoms clusters. Drug Attitude Inventory, 10 items, was used to test attitude towards medications. Adherence to treatments was rated according to the Kemp seven-point scale. We assessed for eligibility 451 individuals and, among them, we included 195 subjects (n = 117 who started PPM1 and n = 78 aripiprazole monohydr…
Constraints on the Coupling between Axionlike Dark Matter and Photons Using an Antiproton Superconducting Tuned Detection Circuit in a Cryogenic Penn…
2021
We constrain the coupling between axionlike particles (ALPs) and photons, measured with the superconducting resonant detection circuit of a cryogenic Penning trap. By searching the noise spectrum of our fixed-frequency resonant circuit for peaks caused by dark matter ALPs converting into photons in the strong magnetic field of the Penning-trap magnet, we are able to constrain the coupling of ALPs with masses around $2.7906-2.7914\,\textrm{neV/c}^2$ to $g_{a\gamma}< 1 \times 10^{-11}\,\textrm{GeV}^{-1}$. This is more than one order of magnitude lower than the best laboratory haloscope and approximately 5 times lower than the CERN axion solar telescope (CAST), setting limits in a mass and cou…
Deferiprone and idebenone rescue frataxin depletion phenotypes in a Drosophila model of Friedreich's ataxia
2013
Friedreich's ataxia (FRDA), the most common inherited ataxia, is a neurodegenerative disease caused by a reduction in the levels of the mitochondrial protein frataxin, the function of which remains a controversial matter. Several therapeutic approaches are being developed to increase frataxin expression and reduce the intramitochondrial iron aggregates and oxidative damage found in this disease. In this study, we tested separately the response of a Drosophila RNAi model of FRDA ( Llorens et al., 2007) to treatment with the iron chelator deferiprone (DFP) and the antioxidant idebenone (IDE), which are both in clinical trials. The FRDA flies have a shortened life span and impaired motor coord…
Problemātika saistībā ar valsts amatpersonu ievēlēšanu, iecelšanu, apstiprināšanu un atbrīvošanu no amata
2020
Bakalaura darba tēma ir problemātika saistībā ar valsts amatpersonu ievēlēšanu, iecelšanu, apstiprināšanu un atbrīvošanu no amata. Darba būtība ir analizēt un izprast galvenās problēmas, kas ir saistītas ar valsts amatpersonu amatu ieņemšanu un atbrīvošanu no tā, izvērtēt tiesiskā regulējuma efektivitāti, izdarīt secinājumus un sniegt priekšlikumus problemātikas novēršanai. Darbā tiek aplūkots Latvijas normatīvo aktu tiesiskais regulējums attiecībā uz tādu valsts amatpersonu kā tiesnešu, ģenerālprokurora, tiesībsarga, valsts kontroliera un citu amatpersonu pilnvaru iegūšanu un izbeigšanos. Šādu amatpersonu iecelšanai amatā ir jābūt balstītai uz neitrālu, objektīvu un uz profesionālajiem kri…
Cytotoxic activity of several ent-kaurane derivatives of atractyligenin. Synthesis of unreported diterpenic skeleton by chemical rearrangement
2022
Atractyloside, carboxyatractyloside, their aglycon atractyligenin, and several synthetic derivatives were tested and found to be active against a panel of human tumor cell lines. Atractyligenin was subjected to oxidation, bromination, and elimination reactions, obtaining several compounds. A singular skeleton was synthesized by chemical rearrangement starting from 3 beta-bromo-2,15-diketoatractyligenin methyl ester. The synthesized compounds resulted active against all cell lines tested. In particular, 15-ketoatractyligenin methyl ester and 3 beta bromo-2,15-diketoatractyligenin methyl ester resulted the most active with IC50 values of 0.427 and 0.723 mu M against A375 melanoma cell line. E…
On the opioid receptor subtype inhibiting the evoked release of 3H-noradrenaline from guinea-pig atria in vitro
1986
1. Guinea-pig isolated atria were incubated and loaded with 3H-(−)-noradrenaline. The intrinsic nerves were stimulated with trains of 5 or 35 field pulses (4 Hz), and the evoked efflux of 3H-noradrenaline and of total tritium was determined in the presence of atropine, corticosterone, desipramine, and phentolamine by liquid scintillation spectrometry. 2. Ethylketocyclazocine (1.4 nmol/l, IC50), MR 2033 (9.1 nmol/l), dynorphin A (1–13) (25 nmol/l, peptidase inhibitors present), etorphine (71 nmol/l), and [d-Ala2, d-Leu5]-enkephalin (>10 μmol/l, peptidase inhibitors present) inhibited the stimulation-evoked efflux of 3H-noradrenaline in a concentration-dependent manner, but not morphine up to…
Audiovisual speech perception in children with developmental language disorder in degraded listening conditions.
2013
Purpose The effect of the signal-to-noise ratio (SNR) on the perception of audiovisual speech in children with and without developmental language disorder (DLD) was investigated by varying the noise level and the sound intensity of acoustic speech. The main hypotheses were that the McGurk effect (in which incongruent visual speech alters the auditory speech percept) would be weaker for children with DLD than for controls and that it would get stronger with decreasing SNR in both groups. Method The participants were 8-year-old children with DLD and a sample of children with normal language development. In the McGurk stimuli, the consonant uttered by the voice differed from that articulated …
Relationships between the social communication questionnaire and pragmatic language, socialization skills, and behavioral problems in children with a…
2019
The Social Communication Questionnaire (SCQ) is one of the most widely used screening instruments for autism spectrum disorder (ASD). This study examined the relationships between the reciprocal social interaction, communication, and repetitive/stereotyped factors on the Strength and Difficulties Questionnaire (SDQ) and pragmatic, socialization, and behavioral problems in children with ASD and children with typical development (TD). Participants were seven- to 11-year-old children with ASD without intellectual disability (