Search results for "IPR"
showing 10 items of 1515 documents
Production, fonction et localisation d'Orchestine: calciprotéine spécifique de la matrice organique des structures minéralisées élaborées par le crus…
2002
As most Crustaceans, Orchestia cavimana possesses a mineralized exoskeleton which is periodically replaced. Because of the terrestrial behaviours of this animal, this molting cycle is related to calcium storage and resorption processes. Calcium storage occurs, as calcareous concretions, in diverticula of the midgut called posterior cæca. Calcareous concretions are essentially composed of amorphous calcium carbonate precipitated within a proteinaceous organic matrix composed of a soluble fraction and an insoluble one in an EDTA-buffer. Among the soluble components of the organic matrix, a previous study led to characterize a polypeptide of 23 kDa in SDS-PAGE called Orchestin. This protein, w…
TORC1 controls G1–S cell cycle transition in yeast via Mpk1 and the greatwall kinase pathway
2015
The target of rapamycin complex 1 (TORC1) pathway couples nutrient, energy and hormonal signals with eukaryotic cell growth and division. In yeast, TORC1 coordinates growth with G1–S cell cycle progression, also coined as START, by favouring the expression of G1 cyclins that activate cyclin-dependent protein kinases (CDKs) and by destabilizing the CDK inhibitor Sic1. Following TORC1 downregulation by rapamycin treatment or nutrient limitation, clearance of G1 cyclins and C-terminal phosphorylation of Sic1 by unknown protein kinases are both required for Sic1 to escape ubiquitin-dependent proteolysis prompted by its flagging via the SCFCdc4 (Skp1/Cul1/F-box protein) ubiquitin ligase complex.…
Atypical Antipsychotics in the Treatment of Acute Bipolar Depression with Mixed Features: A Systematic Review and Exploratory Meta-Analysis of Placeb…
2016
Evidence supporting the use of second generation antipsychotics (SGAs) in the treatment of acute depression with mixed features (MFs) associated with bipolar disorder (BD) is scarce and equivocal. Therefore, we conducted a systematic review and preliminary meta-analysis investigating SGAs in the treatment of acute BD depression with MFs. Two authors independently searched major electronic databases from 1990 until September 2015 for randomized (placebo-) controlled trials (RCTs) or open-label clinical trials investigating the efficacy of SGAs in the treatment of acute bipolar depression with MFs. A random-effect meta-analysis calculating the standardized mean difference (SMD) between SGA an…
Bicausative matrices to measure structural change: Are they a good tool?
1999
The causative-matrix method to analyze temporal change assumes that a matrix transforms one Markovian transition matrix into another by a left multiplication of the first matrix; the method is demand-driven when applied to input-output economics. An extension is presented without assuming the demand-driven or supply-driven hypothesis. Starting from two flow matrices X and Y, two diagonal matrices are searched, one premultiplying and the second postmultiplying X, to obtain a result the closer as possible to Y by least squares. The paper proves that the method is deceptive because the diagonal matrices are unidentified and the interpretation of results is unclear. Keywords : Input-Output ; Ch…
Forecast Output Coincidence and Biproportion: Two Criteria to Determine the Orientation of an Economy. Comparison for France (1980-1997)
2002
International audience; The method of forecast output coincidence used to determine if sectors are demand-sided or supply-sided in an input-output framework mixes two effects, the structural effect (choosing between demand and supply side models) and the effect of an exogenous factor (final demand or added-value). The note recalls that another method is possible, the comparison of the stability of technical and allocation coefficients, generalized by the biproportional filter: if for a sector, after biproportional filtering, column coefficients are more stable than row coefficients, then this sector is declared as not supply-sided (but one cannot decide that it is demand-sided anyway), and …
The variations of technical and allocation coefficients : are they comparable really ?
1995
Two great alternative hypothesis are possible in the analysis input-output : the model may be demand-driven (Leontief) or supply-driven (Ghosh). To test the consistency of these hypotheses on the long term, this paper studies the interest of proportional filters (comparison of column or row coefficients) and the interest of the biproportional filter for the temporalcomparison of input-output matrices. An application is proposed for France between 1980 and 1993. The result is the following : in the long period, there are more sectors supply-driven than demand-driven (i.e. row coefficients are less variable than column coefficients for the majority of the sectors). (FRE) Deux grandes hypothès…
A biproportional filter to compare technical and allocation coefficient variations
1997
International audience; In input-output analysis there are two alternate possibilities between Leontief's mechanism (fixed technical coefficients) and Ghosh's mechanism (fixed allocation coefficients). Testing the long term consistency of these mechanisms entails comparing input-output matrices over time. This paper challenges the value of proportional filters (separate comparison of column and row coefficients) and introduces the biproportional filter which allows simultaneous comparison of column and rows. An application is proposed using French input-output tables for 1980 and 1993. The stability of column coefficients cannot be taken for granted and generally, for any sector, both rows …
The biproportional factorial analysis
1993
Beyond the Factorial Analysis of Correspondences, the paper presents a newmethod of data analysis: the Biproportional Factorial Analysis. In the Factorial Analysis of Correspondences, the matrix to be diagonalised is the product o f the two matrices o f profiles, row and columns: this matrix is not symmetrical. In the Biproportional Factorial Analysis, the matrix to be diagonalised is the symmetrical product o f an intermediate matrix over itself; this intermediate matrix is calculated as the biproportion o f the data matrix over normalisedmargins. This provides a full symmetry between rows and columns. After recalling the Factorial Analysis of Correspondences, the paper recall what it is b…
About the criteria of output coincidence for forecasts to determine the orientation of the economy (application for France, 1980-1997)
2000
This note indicates that the method of output coincidence for forecasts used to determine if sectors are demand-driven or supply-driven in an input-output framework mixes two effects, the structural effect (choosing between demand and supply driven models) and the effect of an exogenous factor (final demand or added-value). The note recalls that another method is possible, the comparison of the stability of technical and allocation coefficients, generalized by the biproportional filter: if for a sector, after biproportional filtering, column coefficients are more stable than row coefficients, then this sector is declared as not supply-driven (but one cannot decide that it is demand-driven a…
Pharmacokinetics of acute and sub-chronic aripiprazole in P-glycoprotein deficient mice
2010
Abstract Background P-glycoprotein (P-gp), an efflux transporter localized in the blood–brain barrier, limits the access of multiple xenobiotics to the central nervous system (CNS). For the new antipsychotic aripiprazole and its active metabolite dehydroaripiprazole differences in disposition in blood and brain were investigated after acute and sub-chronic administration in a P-gp knockout mouse model. Methods Serum and brain concentrations of both drugs were measured at several time points 1–24 h after i.p. injection of 10 mg/kg aripiprazole and after 11 days of sub-chronic administration in several tissues. Moreover, the expression of P-gp was determined by Western blot analysis after sub…