Search results for "IPR"
showing 10 items of 1515 documents
IL CONFINE POROSO. Riverberi nelle Terre Dormienti di Cipro
2020
La lunga linea di confine che si snoda al centro della città di Nicosia ci spinge ad affrontare i problemi dei limiti, dei confini e della porosità. Le scene surreali degli alberi che dominano le strade, dei cactus lussureggianti che avvolgono le case, della vegetazione selvaggia che sale all’interno degli edifici, quasi a tenere insieme gli elementi in caduta libera delle strutture, non può che scuotere radicati preconcetti architettonici. Yiorgos Hadjichristou attualmente vive e opera lungo la ‘Zona morta’ di Nicosia, una zona cuscinetto che si trova tra i due muri che dividono lo stato di Cipro. Tali considerazioni hanno generato un interesse crescente per la giustapposizione di dualità …
“Allouì? Mezus mortu mortu!” Processi identitari, retoriche del passato e mercato culturale in Sardegna
2014
In Europa, e segnatamente in Italia, Halloween continua a dividere ogni anno favorevoli e contrari. Ma quali sono le ragioni che stimolano il rifiuto del festival d’importazione statunitense? Una ma non unica motivazione è il ricordo delle questue infantili tradizionali che in passato scandivano i calendari cerimoniali di numerosi centri della penisola. Scomparse quasi dappertutto, le questue infantili si conservano diffusamente in Sardegna. Qui Halloween convive in alcuni casi con le questue tradizionali, in altri le ha sostituite, ma nella maggior parte dei paesi non si è ancora diffuso. Piuttosto, più o meno recentemente, altre comunità isolane, in risposta ad Halloween, hanno riproposto…
Direct chemical grafted curcumin on halloysite nanotubes as dual-responsive prodrug for pharmacological applications
2016
Covalently functionalized halloysite nanotubes (HNTs) were successfully employed as dual-responsive nanocarriers for curcumin (Cur). Particularly, we synthesized HNT-Cur prodrug with a controlled curcumin release on dependence of both intracellular glutathione (GSH) and pH conditions. In order to obtain HNT-Cur produgs, halloysite was firstly functionalized with cysteamine through disulphide linkage. Afterwards, curcumin molecules were chemically conjugated to the amino end groups of halloysite via Schiff's base formation. The successful functionalization of halloysite was proved by thermogravimetric analysis, FT-IR spectroscopy, dynamic light scattering and scanning electron microscopy. Ex…
SYSTOLIC GENERATION OF k-ARY TREES
1999
The only parallel generating algorithms for k-ary trees are those of Akl and Stojmenović in 1996 and of Vajnovszki and Phillips in 1997. In the first of them, trees are represented by an inversion table and the processor model is a linear aray multicomputer. In the second, trees are represented by bitstrings and the algorithm executes on a shared memory multiprocessor. In this paper we give a parallel generating algorithm for k-ary trees represented by generalized P–sequences for execution on a linear array multicomputer.
Mathematical modeling of oral absorption and bioavailability of a fluoroquinolone after its precipitation in the gastrointestinal tract
2013
The objective was to characterize the in vivo absorption and bioavailability (BA) of a low solubility, high permeability fluoroquinolone (CNV97101) that precipitates in the gastrointestinal (GI) tract by mathematical modeling approach. In situ rat intestinal perfusion studies were performed to characterize the absorption mechanism. The oral fraction absorbed in vivo was lower than the predicted based on the in situ intestinal permeability. Two additional routes of administration, intraduodenal (ID) and intraperitoneal (IP) were investigated to explore if precipitation in stomach and subsequent partial re-dissolution were the causes of the lower in vivo BA. Ex vivo precipitation studies with…
The aryl hydrocarbon receptor-dependent deregulation of cell cycle control induced by polycyclic aromatic hydrocarbons in rat liver epithelial cells
2006
Disruption of cell proliferation control by polycyclic aromatic hydrocarbons (PAHs) may contribute to their carcinogenicity. We investigated role of the aryl hydrocarbon receptor (AhR) in disruption of contact inhibition in rat liver epithelial WB-F344 'stem-like' cells, induced by the weakly mutagenic benz[a]anthracene (BaA), benzo[b]fluoranthene (BbF) and by the strongly mutagenic benzo[a]pyrene (BaP). There were significant differences between the effects of BaA and BbF, and those of the strongly genotoxic BaP. Both BaA and BbF increased percentage of cells entering S-phase and cell numbers, associated with an increased expression of Cyclin A and Cyclin A/cdk2 complex activity. Their eff…
L'ombra lunga di Zarlino
2021
"The long shadow of Zarlino" · The first part is devoted to high¬lighting the special relevance modes have in Zarlino’s writings, where they are considered as “the forms of the compositions”. Zarlino reconsid¬ers, revises, and reorganizes modes from book to book. A crucial point is in the Dimostrationi Harmoniche (1571), with the proposal of a new modal order that no longer begins with D but rather with C. Zarlino wants to convince his readers that this new order is more rational and coherent than the previous one, since all the species of the perfect intervals (diapa¬son, diapente, diatessaron) now start from the same note, C. Moreover, the sequence of the finales finally coincides with th…
Peroxisome proliferator-activated receptors as regulators of lipid metabolism; tissue differential expression in adipose tissues during cold acclimat…
2004
Brown (BAT) and white (WAT) adipose tissues play a key role in the body energy balance orchestrated by the central nervous system. Hibernators have developed a seasonal obesity to respond to inhospitable environment. Jerboa is one of the deep hibernator originated from sub-desert highlands. Thus, this animal represents an excellent model to study cold adaptation mechanism. We report that the adipogenic factor PPARgamma exhibits a differential expression between BAT and WAT at mRNA level. A specific induction was only seen in WAT of pre-hibernating jerboa. Interestingly, PPAR beta/delta is specifically induced in BAT and brain of pre-hibernating jerboa, highlighting for the first time the po…
Hidden sector dark matter and the Galactic Center gamma-ray excess: a closer look
2017
Stringent constraints from direct detection experiments and the Large Hadron Collider motivate us to consider models in which the dark matter does not directly couple to the Standard Model, but that instead annihilates into hidden sector particles which ultimately decay through small couplings to the Standard Model. We calculate the gamma-ray emission generated within the context of several such hidden sector models, including those in which the hidden sector couples to the Standard Model through the vector portal (kinetic mixing with Standard Model hypercharge), through the Higgs portal (mixing with the Standard Model Higgs boson), or both. In each case, we identify broad regions of parame…
Testing the Trust Game with undergraduates: An experiment with wealth heterogeneity
2017
Ponència presentada a 3rd International Conference on Higher Education Advances, HEAd’17, Universitat Politècnica de València, València, 2017 Trust, reciprocity and a fair distribution of resources are cruzial in the sustainability of any economic system. As a matter of fact, those are values that should be promoted among the new generations, especially among university students enrolled in degrees that are related to economics. Under this context, we are interested in enhancing criticism and active reflection among undergraduates with respect to social values. With such a goal in mind, we designed a two step classroom task that includes playing the Trust Game (TG) in the first place and, s…