Search results for "IPR"
showing 10 items of 1515 documents
Conclusione generale
2009
Le ipotesi relative alla congruenza delle attività formative progettate con gli obiettivi che ci si prefiggeva di raggiungere sono state verificate in un campione di livello medio-alto per la competenza metacognitiva.
The Reciprocal Relationship Between Emotions and Agency in the Workplace
2017
In conjunction with a growing interest in professional agency, there is a need to understand how emotions are embedded in agentic practice. This chapter examines the emotions bound up with work and how these emotions are related to professional agency. The subjects of our study were leaders (middle management) and employees working in Finnish education and health-care organisations. A qualitative meta-synthesis was conducted to describe the relationship between professional agency and emotions. The study revealed a variety of emotions, including fear and enjoyment, related to professional identity, work, and social relationships. Among both employees and leaders, emotions were found to play…
Synthesis of Triazenoazaindoles: a New Class of Triazenes with Antitumor Activity
2011
Despite improvements in the treatment and prevention of cancer, the number of new diagnoses continues to rise; this has fuelled substantial interest in the development of new and effective chemotherapeutic agents. Compounds of the triazene class, such as dacarbazine, have been used in the clinical management of many cancer types including brain, leukemia, and melanoma. A new compound class bearing a triazenoazaindole scaffold was synthesized with the aim of identifying new antiproliferative agents. Compounds 5 a-g and 6 a-c were screened against a panel of human tumor cell lines, and two of them, 5 e and 5 f, showed cytotoxicity (GI(50) range: 2.2-8.2 μM) in all cell lines. These two compou…
Synthesis of a new class of pyrrolo[3,4-h]quinazolines with antimitotic activity
2014
Abstract A new series of pyrrolo[3,4- h ]quinazolines was conveniently prepared with a broad substitution pattern. A large number of derivatives was obtained and the cellular cytotoxicity was evaluated in vitro against 5 different human tumor cell lines with GI 50 values reaching the low micromolar level (1.3–19.8 μM). These compounds were able to induce cell death mainly by apoptosis through a mitochondrial dependent pathway. Selected compounds showed antimitotic activity and a reduction of tubulin polymerization in a concentration-dependent manner. Moreover, they showed anti-angiogenic properties since reduced in vitro endothelial cell migration and disrupted HUVEC capillary-like tube net…
Pyrazolo[3,4-h]quinolines promising photosensitizing agents in the treatment of cancer.
2015
A new series of pyrazolo[3,4-h]quinolines, heteroanalogues of angelicin was conveniently prepared with a broad substitution pattern. A large number of derivatives was obtained and the cellular photocytotoxicity was evaluated in vitro against 5 different human tumor cell lines with GI50 values reaching the nanomolar level (14.52e0.04 mM). Selected compounds were able to photoinduce a massive cell death with the involvement of mitochondria. Their photodamage cellular targets were proteins and lipids and they did not cause any kind of DNA photodamage. This latter event is of considerable importance in the modulation of long term side effects, generally associated with the use of classical furo…
On the arithmetically Cohen-Macaulay property for sets of points in multiprojective spaces
2017
We study the arithmetically Cohen-Macaulay (ACM) property for finite sets of points in multiprojective spaces, especially ( P 1 ) n (\mathbb P^1)^n . A combinatorial characterization, the ( ⋆ ) (\star ) -property, is known in P 1 × P 1 \mathbb P^1 \times \mathbb P^1 . We propose a combinatorial property, ( ⋆ s ) (\star _s) with 2 ≤ s ≤ n 2\leq s\leq n , that directly generalizes the ( ⋆ ) (\star ) -property to ( P 1 ) n (\mathbb P^1)^n for larger n n . We show that X X is ACM if and only if it satisfies the ( ⋆ n ) (\star _n) -property. The main tool for several of our results is an extension to the multiprojective setting of certain liaison methods in projective space.
Standard, standardizzazione e applicazione dell’art. 102 Tfue ai conflitti su licenze relative a diritti di proprietà intellettuale
2014
La standardizzazione, derivi essa dal funzionamento di un mercato (standardizzazione de facto), sia essa de iure (cioè oggetto di consapevole scelta, concordata tra gli operatori di un mercato), dà luogo a possibili questioni di rilevanza per il diritto antitrust. Soprattutto negli ultimi anni, la giurisprudenza europea e quella di alcuni stati membri hanno in particolare affrontato la questione del mancato rispetto dei cosiddetti impegni FRAND, assunti in sede di standardizzazione de iure dai titolari di quei brevetti divenuti essenziali per conformarsi allo standard selezionato (Standard Essential Patents - SEPs). La Commissione europea e le Corti hanno così già più volte applicato le dis…
Improved Assessment of Pathological Regurgitation in Patients with Prosthetic Heart Valves by Multiplane Transesophageal Echocardiography
1997
The aim of this study was to evaluate the diagnostic increment of individually optimized axes in the assessment of pathological prosthetic valve regurgitation. Forty-two patients with pathologically regurgitant prostheses in the aortic (n = 21), mitral (n = 15), and tricuspid (n = 6) positions were examined by multiplane transesophageal echocardiography. The investigation was performed utilizing the transverse axis first, the longitudinal axis second, and the intermediate axes afterwards. The presence of regurgitation, the differentiation between trans- and perivalvular origin, and the localization of perivalvular leakages at the sewing ring were evaluated. Findings in the biplane and inter…
Antiproliferative Properties of a Few Auranofin-Related Gold(I) and Silver(I) Complexes in Leukemia Cells and their Interferences with the Ubiquitin …
2020
A group of triethylphosphine gold(I) and silver(I) complexes, structurally related to auranofin, were prepared and investigated as potential anticancer drug candidates. The antiproliferative properties of these metal compounds were assessed against two leukemia cell lines, i.e., CCRF-CEM and its multidrug-resistant counterpart, CEM/ADR5000. Interestingly, potent cytotoxic effects were disclosed for both series of compounds against leukemia cells, with IC50 values generally falling in the low-micromolar range, the gold derivatives being on the whole more effective than the silver analogues. Some initial structure-function relationships were drawn. Subsequently, the ability of the study compo…
Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products
2021
Funding Information: We would like to thank A. Löfhjelm and L. Saari for excellent technical assistance. This work was supported by a Sigrid Jusélius Foundation grant to H.K. and the Academy of Finland funding (321809) to T.S. We would also like to thank the Erkko Foundation and Nordforsk Nordic center of Excellency NordAqua (project number #82845) and University of Helsinki’s Doctoral Programme in Microbiology and Biotechnology funding to M.N.A. D.O.A. was supported by a postdoctoral research fellowship from the São Paulo Research Foundation (FAPESP #2018/01563-2). We thank Biocenter Kuopio for the use of their facilities for molecular modeling and MD simulations. We thank the DNA Sequenci…