Search results for "IPR"

Alternative mechanisms for tiotropium

2009

Tiotropium is commonly used in the treatment of chronic obstructive pulmonary disease. Although largely considered to be a long-acting bronchodilator, its demonstrated efficacy in reducing the frequency of exacerbations and preliminary evidence from early studies indicating that it might slow the rate of decline in lung function suggested mechanisms of action in addition to simple bronchodilation. This hypothesis was examined in the recently published UPLIFT study and, although spirometric and other clinical benefits of tiotropium treatment extended to four years, the rate of decline in lung function did not appear to be reduced by the addition of tiotropium in this study. This article summ…

Special arrangements of lines: Codimension 2 ACM varieties in P 1 × P 1 × P 1

2019

In this paper, we investigate special arrangements of lines in multiprojective spaces. In particular, we characterize codimension 2 arithmetically Cohen–Macaulay (ACM) varieties in [Formula: see text], called varieties of lines. We also describe their ACM property from a combinatorial algebra point of view.

Multiprojective spaces and the arithmetically Cohen-Macaulay property

2019

AbstractIn this paper we study the arithmetically Cohen-Macaulay (ACM) property for sets of points in multiprojective spaces. Most of what is known is for ℙ1× ℙ1and, more recently, in (ℙ1)r. In ℙ1× ℙ1the so called inclusion property characterises the ACM property. We extend the definition in any multiprojective space and we prove that the inclusion property implies the ACM property in ℙm× ℙn. In such an ambient space it is equivalent to the so-called (⋆)-property. Moreover, we start an investigation of the ACM property in ℙ1× ℙn. We give a new construction that highlights how different the behavior of the ACM property is in this setting.

Additivity of the Equationally-Defined Commutator and Relatively Congruence-Distributive Subquasivarieties

2015

A fuzzification of the category of M-valued L-topological spaces

2004

[EN] A fuzzy category is a certain superstructure over an ordinary category in which ”potential” objects and ”potential” morphisms could be such to a certain degree. The aim of this paper is to introduce a fuzzy category FTOP(L,M) extending the category TOP(L,M) of M-valued L- topological spaces which in its turn is an extension of the category TOP(L) of L-fuzzy topological spaces in Kubiak-Sostak’s sense. Basic properties of the fuzzy category FTOP(L,M) and its objects are studied.

Artin groups of spherical type up to isomorphism

2003

AbstractWe prove that two Artin groups of spherical type are isomorphic if and only if their defining Coxeter graphs are the same.

Unicity of biproportion

1994

International audience; The biproportion of S on margins of M is called the intern composition law, K: (S,M) -> X = K(S,M) / X = A S B. A and B are diagonal matrices, algorithmically computed, providing the respect of margins of M. Biproportion is an empirical concept. In this paper, the author shows that any algorithm used to compute a biproportion leads to the me result. Then the concept is unique and no longer empirical. Some special properties are also indicated.

An efficient synthesis of pyrrolo[3',2':4,5]thiopyrano[3,2-b]pyridin-2-one: a new ring system of pharmaceutical interest

2012

Abstract A series of pyrrolo[3′,2′:4,5]thiopyrano[3,2- b ]pyridin-2-ones 4 was prepared in good yields by reacting enaminoketones with cyanomethylene active compounds such as phenylsulfonylacetonitrile, benzoylacetonitrile, and malononitrile. Derivatives of the title ring system were tested by the National Cancer Institute of Bethesda against a panel of about 60 human tumor cell lines, and one of them showed inhibitory activity against all cancer cell lines reaching on 48% of them GI 50 values at submicromolar level and on the majority of the remaining ones in the low micromolar concentration.

Machine learning-based models to predict modes of toxic action of phenols to Tetrahymena pyriformis.

2017

The phenols are structurally heterogeneous pollutants and they present a variety of modes of toxic action (MOA), including polar narcotics, weak acid respiratory uncouplers, pro-electrophiles, and soft electrophiles. Because it is often difficult to determine correctly the mechanism of action of a compound, quantitative structure-activity relationship (QSAR) methods, which have proved their interest in toxicity prediction, can be used. In this work, several QSAR models for the prediction of MOA of 221 phenols to the ciliated protozoan Tetrahymena pyriformis, using Chemistry Development Kit descriptors, are reported. Four machine learning techniques (ML), k-nearest neighbours, support vector…

Antiprotozoan lead discovery by aligning dry and wet screening: Prediction, synthesis, and biological assay of novel quinoxalinones

2014

Protozoan parasites have been one of the most significant public health problems for centuries and several human infections caused by them have massive global impact. Most of the current drugs used to treat these illnesses have been used for decades and have many limitations such as the emergence of drug resistance, severe side-effects, low-to-medium drug efficacy, administration routes, cost, etc. These drugs have been largely neglected as models for drug development because they are majorly used in countries with limited resources and as a consequence with scarce marketing possibilities. Nowadays, there is a pressing need to identify and develop new drug-based antiprotozoan therapies. In …