Search results for "IPT"
showing 10 items of 6114 documents
IL-12 Expands and Differentiates Human Vγ2Vδ2 T Effector Cells Producing Antimicrobial Cytokines and Inhibiting Intracellular Mycobacterial Growth
2019
While IL-12 plays a key role in differentiation of protective CD4+ Th1 response, little is known about mechanisms whereby IL-12 differentiates other T-cell populations. Published studies suggest that predominant Vγ2Vδ2 T cells in humans/nonhuman primates (NHP) are a fast-acting T-cell subset, with capacities to rapidly expand and produce Th1 and cytotoxic cytokines in response to phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by Mycobacterium tuberculosis (Mtb) or others. However, whether IL-12 signaling pathway mediates fast-acting and Th1 or anti-microbial features of Vγ2Vδ2 T cells remains poorly defined. Here, we show that IL-12, but not other IL-12 fami…
IL-2 Expression in Activated Human Memory FOXP3(+) Cells Critically Depends on the Cellular Levels of FOXP3 as Well as of Four Transcription Factors …
2012
The human CD4(+)FOXP3(+) T cell population is heterogeneous and consists of various subpopulations which remain poorly defined. Anergy and suppression are two main functional characteristics of FOXP3(+)Treg cells. We used the anergic behavior of FOXP3(+)Treg cells for a better discrimination and characterization of such subpopulations. We compared IL-2-expressing with IL-2-non-expressing cells within the memory FOXP3(+) T cell population. In contrast to IL-2-non-expressing FOXP3(+) cells, IL-2-expressing FOXP3(+) cells exhibit intermediate characteristics of Treg and Th cells concerning the Treg cell markers CD25, GITR, and Helios. Besides lower levels of FOXP3, they also have higher levels…
Comparison of Immunosuppressive and Angiogenic Properties of Human Amnion-Derived Mesenchymal Stem Cells between 2D and 3D Culture Systems
2019
The secretion of potential therapeutic factors by mesenchymal stem cells (MSCs) has aroused much interest given the benefits that it can bring in the field of regenerative medicine. Indeed, the in vitro multipotency of these cells and the secretive capacity of both angiogenic and immunomodulatory factors suggest a role in tissue repair and regeneration. However, during culture, MSCs rapidly lose the expression of key transcription factors associated with multipotency and self-renewal, as well as the ability to produce functional paracrine factors. In our study, we show that a three-dimensional (3D) culture method is effective to induce MSC spheroid formation, to maintain the multipotency an…
Textos mèdics, morals i culinaris en un còdex valencià excepcional. Anàlisi del ms. 216 de la Biblioteca Històrica de la Universitat de València
2015
[cat] Estudi i proposta de reconstrucció del ms. 216 de la Biblioteca Històrica de la Universitat de València. Es tracta d'un còdex de la primera meitat del s. XV, actualment restaurat, que ha patit importants pèrdues de folis, mentre que altres han estat relligats en ordre incorrecte. El volum conté obres mèdiques i doctrinals, com ara traduccions catalanes del Thesarus pauperum de Pere Hispà, del Macer floridus d'Odó de Meung o del llibre II dels Disticha Catonis, i també obres escrites originalment en català, com el Llibre de Sent Soví i els Mil proverbis de Ramon Llull. El mal estat del volum ha dificultat la constatació d'alguns aspectes relatius a la seva constitució, que apunten vers…
Semblanza iconográfica de la realeza sapiencial de Alfonso X: las miniaturas liminares de los códices regios
2016
La producción libraria de Alfonso X testimonia la simbiosis perfecta entre las funciones de gobierno y la labor intelectual y sistematiza su ideario político y cultural, no solo en texto, sino también en imagen. A partir de las miniaturas liminares de los códices regios, se evidencia que el motivo icónico privilegiado en la representación personal de Alfonso X es el rey con el libro: se analizan las distintas variantes de este modelo iconográfico que estampa la amplia gama de atribuciones que conforman el concepto de autoría alfonsí y consolida el modelo de la realeza sapiencial castellana.
El «llibre cortés de lectura» en català: a propòsit del manuscrit F-129 del Col·legi de la Sapiència de Palma
2006
The manuscript F-129 of the Col·legi de la Sapiència de Palma contains three works of Ramon Llull. It is made up of two separate manuscripts belonging to the first generation of Lullian codices (that is, not later than the first quarter of the fourteenth century). This collection is preceded by a remarkable full-page illustration, an analysis of which shows that it was probably based on a similar miniature from a French codex emanating from Llull’s immediate circle. The codicological model applicable to this manuscrit is that of «libro cortese di lettura».
El nou paradigma dels estudis de traducció: (notes arran d'un article de Mona Baker)
2006
This introduction tries to contextualize Mona Baker’s article in this same issue by revising her personal evolution in the field of Translation Studies, as well as by introducing some of the key notions tackled in her paper. The introduction mainly deals with the turn of Translation Studies into a new ideological paradigm which tries to overcome the alleged scientific and aseptic methodology of Descriptive Translation Studies. The concepts of descriptive methodology, ideology, frame and narrative theory are also discussed, with some examples of recent events. Attention is also paid to the Catalan context, where translations and language use also obey to certain ideological and political age…
Parasite presence induces gene expression changes in an ant host related to immunity and longevity
2021
Most species are either parasites or exploited by parasites, making parasite&ndash
The distributions of protein coding genes within chromatin domains in relation to human disease.
2019
Abstract Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented resolution of genome-wide interaction maps shows functional consequences that extend the initial thought of an efficient DNA packaging mechanism: gene regulation, DNA repair, chromosomal translocations and evolutionary rearrangements seem to be only the peak of the iceberg. One key concept emerging from this research is the topologically associating domains (TADs) whose functional role in gene regulation and their association with disease is not fully untangled. Resul…
cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel
2020
Abstract Background Resistance to enteric pathogens is a complex trait at the crossroads of multiple biological processes. We have previously shown in the Drosophila Genetic Reference Panel (DGRP) that resistance to infection is highly heritable, but our understanding of how the effects of genetic variants affect different molecular mechanisms to determine gut immunocompetence is still limited. Results To address this, we perform a systems genetics analysis of the gut transcriptomes from 38 DGRP lines that were orally infected with Pseudomonas entomophila. We identify a large number of condition-specific, expression quantitative trait loci (local-eQTLs) with infection-specific ones located …