Search results for "IPT"
showing 10 items of 6114 documents
2020
ObjectiveThe HBV HBx regulatory protein is required for transcription from the covalently closed circular DNA (cccDNA) minichromosome and affects the epigenetic control of both viral and host cellular chromatin.DesignWe explored, in relevant cellular models of HBV replication, the functional consequences of HBx interaction with DLEU2, a long non-coding RNA (lncRNA) expressed in the liver and increased in human hepatocellular carcinoma (HCC), in the regulation of host target genes and the HBV cccDNA.ResultsWe show that HBx binds the promoter region, enhances the transcription and induces the accumulation of DLEU2 in infected hepatocytes. We found that nuclear DLEU2 directly binds HBx and the…
Salt and Aroma Compound Distributions Influence Flavour Release and Temporal Perception While Eating Hot-Served Flans.
2021
International audience; To counteract the negative effect of salt overconsumption on health, strategies have been developed to reduce the salt content in food products. Among them, two promising strategies based on odour-induced saltiness enhancement and the heterogeneous distribution of flavour compounds were combined and assessed in four-layer cream-based snacks. To investigate the relationship between saltiness enhancement, temporal release and perception of flavour compounds in hot snacks with heterogeneous distribution of salt and aroma compounds, complementary techniques were used: nose space PTR-Tof-MS (Proton Transfer Reaction-Time of Flight–Mass Spectrometry) to assess the release …
Comparison of conventional descriptive analysis and a citation frequency-based descriptive method for odor profiling: An application to Burgundy Pino…
2010
International audience; The limitations of intensity scoring when describing the odor characteristics of a complex product have been documented in the literature. In the present work, the odor properties of 12 Burgundy Pinot noir wines were described by two independent panels performing, respectively, an intensity-based (conventional descriptive analysis) and a citation frequency-based method. Methods were compared according to three criteria: similarity of the sensory maps, control of panel performance and practical aspects. Intensity scoring and citation frequency data were analyzed, respectively, by Principal Components Analysis (PCA) and Correspondence Analysis (CA) followed by Hierarch…
‘I just want someone to rub some life into them!’ : the lived experience of impaired sensation in the feet related to multiple sclerosis
2021
Background: Impaired sensation in the feet is a commonly reported symptom experienced by people with multiple sclerosis. Aim: To explore the lived experiences of people living with multiple sclerosis-related impaired sensation in their feet. Method: Five open, unstructured interviews were analysed using a descriptive phenomenological method developed by Amedeo Giorgi. Findings: The essential structure of the research phenomenon consists of six key constituents: sense of heightened awareness of body sensation; sense of changed relationship to the feet; sense of changed participation in daily life; sense of the self with multiple sclerosis; sense of the meaning of interaction with others; and…
Simplification Of Painting Images For Tactile Perception By Visually Impaired Persons
2018
The access to artworks by visually impaired people requires a simplified tactile representation of paintings. This paper presents the difficulties of direct transcription of artworks and the test results of simplification of the paintings done by Australian Aborigines which don't have purely visual elements such as shadows or perspective. The implemented methodology is bottom-up: it starts with tactile representation of basic elements relevant to the understanding of the whole painting, then their association into more complex concepts. The context of associations is explained through audio-description. The results of the tests with visually impaired persons are analyzed and explained.
An Illustration to Ælfric’s De temporibus anni in Ælfwine’s Prayerbook
2020
L'articolo esamina un diagramma contenuto nel manoscritto London, British Library, Cotton Titus D.xxvii+xxvi, generalmente noto come 'Ælfwine’s Prayerbook'. Il diagramma, che si trova al fol. 21 v , è stato in genere interpretato come una rota incompleta, o delle maree o dei venti (dal momento che contiene solo 4 dei canonici 12 venti della tradizione scientifica medievale). Una analisi comparativa e dettagliata delle caratteristiche del diagramma, tuttavia, mostra come l'ipotesi della rota delle maree sia da rigettare in favore della teoria di una rota ventorum. Inoltre, l'analisi dei testi contenuti nel manoscritto rivela una stretta connessione tra il diagramma e il De temporibus anni di…
How Hand Gestures Contribute to Action Ascription
2019
ABSTRACTThis article investigates the embodied achievement of intersubjectivity by analyzing depictive gestures that are produced during the final components of the ongoing verbal TCU and extended ...
Discordances in Ascriptions of Agency and Reflectivity in the First Psychotherapy Session
2018
We analyzed the first sessions of nine long-term individual psychotherapies with a model of ten discursive tools of agency ascription and studied discursive discordances, sequences of two talk turns in which the therapeutic dyad was misaligned in terms of how they ascribed agency to the client. We also studied how the clients’ agency self-ascriptions in the turn immediately following the discordances changed from the first turn. Classifying these discordance sequences, eight different types of sequences were found. One, in which the clients’ reflective agency constructions were missed by the therapists, was subjected to a detailed analysis. peerReviewed
Interpersonal Counseling in the Treatment of Adolescent Depression: A Randomized Controlled Effectiveness and Feasibility Study in School Health and …
2019
AbstractIn order to offer early and accessible treatment for adolescents with depression, brief and effective treatments in adolescents’ everyday surroundings are needed. This randomized controlled trial studied the preliminary effectiveness, feasibility, and acceptability of interpersonal counseling (IPC) and brief psychosocial support (BPS) in school health and welfare services. The study was conducted in the 28 lower secondary schools of a large city in Southern Finland, randomized to provide either IPC or BPS. Help-seeking 12–16-year-old adolescents with mild-to-moderate depression, with and without comorbid anxiety, were included in the study. Fifty-five adolescents received either 6 w…
Why women do not use the helmet when riding a bicycle
2018
Women seem to use the helmet when riding a bicycle less frequently than men. Two possible explanations for this behavior are that 1) it is less appalling to them because of lack of comfort or other reasons, or 2) they use bicycles in a more cautious way than men so they feel that they do not need the helmet as much. The present paper explores these two explanations in 5,691 cyclists that responded to an online survey conducted in 17 countries as part of an EU COST project. Answers to questions related to the two aforementioned explanations were analyzed graphically and three questions that showed the most conspicuous differences between males and females were identified. These were: ‘Helme…