Search results for "IRM"

Effect of COVID-19 quarantine on cognitive, functional and neuropsychiatric symptoms in patients with mild cognitive impairment and dementia.

2022

Abstract Background During the last two years, COVID-19 affected older people with dementia or mild cognitive impairment (MCI), but conflicting and sparse results are still present. The objective of this study was to investigate the frequency and type of changes in functional, cognitive and behavioral and psychological symptoms of dementia (BPSD), and caregiver’s stress during the period of quarantine in 2020 in patients affected by dementia/MCI living in Palermo, Sicily. Methods Outpatients affected by MCI/dementia were evaluated before and after COVID-19 quarantine. Functional status was investigated using basic and instrumental activities of daily living (ADL); cognitive performance with…

Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment

2009

Alzheimer's disease (AD) is the most common type of dementia in the elderly. Products of oxidative and nitrosative stress (OS and NS, respectively) accumulate with aging, which is the main risk factor for AD. This provides the basis for the involvement of OS and NS in AD pathogenesis. OS and NS occur in biological systems due to the dysregulation of the redox balance, caused by a deficiency of antioxidants and/or the overproduction of free radicals. Free radical attack against lipids, proteins, sugars and nucleic acids leads to the formation of bioproducts whose detection in fluids and tissues represents the currently available method for assessing oxidative/nitrosative damage. Post-mortem …

Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid de…

2012

Alzheimer's disease (AD) is characterized by amyloid-beta deposition in amyloid plaques, neurofibrillary tangles, inflammation, neuronal loss, and cognitive deficits. Cannabinoids display neuromodulatory and neuroprotective effects and affect memory acquisition. Here, we studied the impact of cannabinoid receptor type 1 (CB1) deficiency on the development of AD pathology by breeding amyloid precursor protein (APP) Swedish mutant mice (APP23), an AD animal model, with CB1-deficient mice. In addition to the lower body weight of APP23/CB1(-/-) mice, most of these mice died at an age before typical AD-associated changes become apparent. The surviving mice showed a reduced amount of APP and its …

Poor vision accompanied with other sensory impairments as a predictor of falls in older women

2008

Objectives:we studied visual acuity (VA) and co-existing hearing impairment and poor standing balance as predictors of falls. Design: prospective study with 1-year follow-up. Setting: research laboratory and residential environment. Participants: 428 women aged 63‐76 years from the Finnish Twin Study on Aging. Measurements: participants were followed up for incidence of falls over 1 year. VA, hearing ability and standing balance were assessed at the baseline. The incidence rate ratios (IRR) for falls were computed using the negative binomial regression model. Results: during the follow-up, 47% of participants experienced a fall. After adjusting for age and interdependence of twin sisters, p…

Methods matter: Testing competing models for designing short-scale Big-Five assessments

2015

Abstract Many psychological instruments are psychometrically inadequate because derived person-parameters are unfounded and models will be rejected using established psychometric criteria. One strategy towards improving the psychometric properties is to shorten instruments. We present and compare the following procedures for the abbreviation of self-report assessments on the Trait Self-Description Inventory in a sample of 14,347 participants: (a) Maximizing reliability/main loadings, (b) Minimizing modification indices/cross loadings, (c) the PURIFY Algorithm in Tetrad, (d) Ant Colony Optimization, and (e) a genetic algorithm. Ant Colony Optimization was superior to all other methods in imp…

Bērnu agresīvas uzvedības novēršanas iespējas 5-6 gadu vecumā

2022

Bakalaura darba autors ir Latvijas Universitātes 5. kursa studente Alise Paula Pušmucāne. Izvēlētā bakalaura darba tēma ir ’’Bērnu agresīvas uzvedības novēršanas iespējas vecākajā pirmsskolas vecumā’’ . Bakalaura darba mērķis ir noskaidrot ar kādiem pedagoģiskajiem paņēmieniem ir iespējams mazināt vai novērst pirmsskolas vecākā vecuma bērnu agresīvu uzvedību. Darbs sastāv no teorētiskās un empīriskās daļas. Darbā veikta teorētiska agresīvas uzvedības jēdziena izpēte, bērnu attīstības likumsakarību izpēte atbilstoši vecumposmam , pētīti citi uzvedību ietekmējoši faktori pirmsskolas vecākajā vecumā, kā arī pētīti un analizēti pedagoģiskie paņēmieni agresīvas uzvedības novēršanai, tai skaitā l…

Agrīnā pirmsskolas vecuma bērnu fiziskās attīstības sekmēšana kustību rotaļās

2018

Darba nosaukums: Agrīnās pirmsskolas vecuma bērnu fiziskās attīstības sekmēšana kustību rotaļās. Darba autors: Lilija Kručeka Darba vadītāja: Dr. paed. Inta Bula-Biteniece Darba saturs: Kvalifikācijas darbs sastāv no divām daļām – teorētiskās un praktiskās daļas. Darbā ir ievads, secinājumi, priekšlikumi, literaturas saraksts, 2 tabulas, 23 attēli un 2 pielikumi. Darba apjoms 49 lapas. Analizēti 36 literatūras avoti. Pētījuma mērķis: Izprast agrīnā pirmsskolas vecuma bērnu fizisko aktivitāti un sekmēt to kustību rotaļās. Pētījuma teorētiskajā daļā ir analizēta dažādu pedagogu un psihologu domas un attieksme par kustību attīstību bērnu dzīvē, par kustību rotaļu nozīmi bērna fiziskajā attīstī…

Vēsture: Latvijas Universitātes Žurnāls, 2018, Nr.6

2019

Fiabilidad y validez de constructo de la traducción al valenciano/catalán del Cuestionario para la Evaluación del Síndrome de Quemarse por el trabajo…

2021

The aim of this study was to evaluate the reliability and construct validity of the Valencian/Catalonian version of the Spanish Burnout Inventory (SBI) in a sample of non-university teachers from the Valencia province (Spain). The sample consisted of 1359 teachers (67.2% were women). This instrument contains 20 items distributed into four dimensions: Enthusiasm toward the job (5 items), Psychological exhaustion (4 items), Indolence (6 items) and Guilt (5 items). The psychometric properties were examined through the following analyses: confirmatory factor analysis (CFA) and reliability (Cronbach’s alpha). All items achieved appropriate values for both statistical and psychometric parameters,…

Genistein effect on cognition in prodromal Alzheimer's disease patients : the GENIAL clinical trial

2022

Background: Delaying the transition from minimal cognitive impairment to Alzheimer’s dementia is a major concern in Alzheimer’s disease (AD) therapeutics. Pathological signs of AD occur years before the onset of clinical dementia. Thus, long-term therapeutic approaches, with safe, minimally invasive, and yet efective substances are recommended. There is a need to develop new drugs to delay Alzheimer’s dementia. We have taken a nutritional supplement approach with genistein, a chemically defned polyphenol that acts by multimodal specifc mechanisms. Our group previously showed that genistein supplementation is efective to treat the double transgenic (APP/PS1) AD animal model. Methods: In this…