Search results for "ISMU"
showing 10 items of 685 documents
Journalists’ Associations as Political Instruments in Central and Eastern Europe
2017
This editorial provides the overall context for the five cases—three national and two international—covered in this thematic issue. While the cases are from Central and Eastern Europe (CEE), they highlight fundamental questions of journalism everywhere, including contradictions between freedom and control, professionalism and politics, individual and collective. The associations of journalists serve as very useful platforms to study these questions, especially at historical turning points when the whole political system changed, as happened twice in CEE after World War II.
Analytical techniques for the determination of bismuth in solid environmental samples
2006
Abstract Bismuth is a trace element of the Earth’s crust, which is becoming environmentally significant. Although bismuth has relatively low toxicity, it can form characteristic intracytoplasmatic inclusions. This article illustrates the increasing need for fast pre-treatment techniques and highly sensitive detection methods for accurate measurements of bismuth at extremely low concentrations in solid environmental matrices.
Laser spectroscopy of the ground-state hyperfine structure in H-like and Li-like bismuth
2014
The LIBELLE experiment performed at the experimental storage ring (ESR) at the GSI Helmholtz Center in Darmstadt aims for the determination of the ground state hyperfine (HFS) transitions and lifetimes in hydrogen-like (209Bi82+) and lithium-like (209Bi80+) bismuth. The study of HFS transitions in highly charged ions enables precision tests of QED in extreme electric and magnetic fields otherwise not attainable in laboratory experiments. While the HFS transition in H-like bismuth was already observed in earlier experiments at the ESR, the LIBELLE experiment succeeded for the first time to measure the HFS transition in Li-like bismuth in a laser spectroscopy experiment.
Facebook’s Emotional Contagion Experiment as a Challenge to Research Ethics
2016
This article analyzes the ethical discussion focusing on the Facebook emotional contagion experiment published by the <em>Proceedings of the National Academy of Sciences</em> in 2014. The massive-scale experiment manipulated the News Feeds of a large amount of Facebook users and was successful in proving that emotional contagion happens also in online environments. However, the experiment caused ethical concerns within and outside academia mainly for two intertwined reasons, the first revolving around the idea of research as manipulation, and the second focusing on the problematic definition of informed consent. The article concurs with recent research that the era of social med…
Localizing the politics of privacy in communication and media research
2020
While previous communication and media research has largely focused on either studying privacy as personal boundary management or made efforts to investigate the structural (legal or economic) condition of privacy, we observe an emergent body of research on the political underpinnings of privacy linking both aspects. A pronounced understanding of the politics of privacy is however lacking. In this contribution, we set out to push this forward by mapping four communication and media perspectives on the political implications of privacy. In order to do so, we recur on Barry’s (2002) distinction of the political and the politics and outline linkages between individual and structural dimensions…
The Politics of Privacy - a Useful Tautology
2020
While communication and media studies tend to define privacy with reference to data security, current processes of datafication and commodification substantially transform ways of how people act in increasingly dense communicative networks. This begs for advancing research on the flow of individual and organizational information considering its relational, contextual and, in consequence, political dimensions. Privacy, understood as the control over the flow of individual or group information in relation to communicative actions of others, frames the articles assembled in this thematic issue. These contributions focus on theoretical challenges of contemporary communication and media privacy …
Genome-wide variant calling in reanalysis of exome sequencing data uncovered a pathogenic TUBB3 variant.
2021
Almost half of all individuals affected by intellectual disability (ID) remain undiagnosed. In the Solve-RD project, exome sequencing (ES) datasets from unresolved individuals with (syndromic) ID (n = 1,472 probands) are systematically reanalyzed, starting from raw sequencing files, followed by genome-wide variant calling and new data interpretation. This strategy led to the identification of a disease-causing de novo missense variant in TUBB3 in a girl with severe developmental delay, secondary microcephaly, brain imaging abnormalities, high hypermetropia, strabismus and short stature. Interestingly, the TUBB3 variant could only be identified through reanalysis of ES data using a genome-wi…
Harder, Better, Faster, Stronger? The Relationship between Cognitive Task Demands in Video Games and Recovery Experiences
2019
Research has repeatedly demonstrated that the use of interactive media is associated with recovery experiences, suggesting that engaging with media can help people to alleviate stress and restore mental and physical resources. Video games, in particular, have been shown to fulfil various aspects of recovery, not least due to their ability to elicit feelings of mastery and control. However, little is known about the role of cognitive task demand (i.e., the amount of cognitive effort a task requires) in that process. Toward this end, our study aimed to investigate how cognitive task demand during gameplay affects users’ recovery experiences. Results of a laboratory experiment suggest that dif…
BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins.
2010
Increasing evidence indicates the existence of selective autophagy pathways, but the manner in which substrates are recognized and targeted to the autophagy system is poorly understood. One strategy is transport of a particular substrate to the aggresome, a perinuclear compartment with high autophagic activity. In this paper, we identify a new cellular pathway that uses the specificity of heat-shock protein 70 (Hsp70) to misfolded proteins as the basis for aggresome-targeting and autophagic degradation. This pathway is regulated by the stress-induced co-chaperone Bcl-2-associated athanogene 3 (BAG3), which interacts with the microtubule-motor dynein and selectively directs Hsp70 substrates …
Wild-type Cu/Zn superoxide dismutase (SOD1) does not facilitate, but impedes the formation of protein aggregates of amyotrophic lateral sclerosis cau…
2009
Aggregation of Cu/Zn superoxide dismutase (SOD1) is a hallmark of a subset of familial amyotrophic lateral sclerosis (ALS) cases. The expression of wild-type SOD1 [SOD(hWT)] surprisingly exacerbates the phenotype of mutant SOD1 in vivo. Here we studied whether SOD1(hWT) may affect mutant SOD1 aggregation by employing fluorescence microscopy techniques combined with lifetime-based Förster resonance energy transfer (FRET). Only a very minor fraction of SOD1(hWT) was observed in aggregates induced by mutant SOD1(G37R), SOD1(G85R) or SOD1(G93C). Quite in contrast, co-expression of SOD(hWT) reduced the amount of mutant SOD1 in the aggregate fraction. Furthermore, we did not detect endogenous mou…