Search results for "ISMU"
showing 10 items of 685 documents
Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-di…
2011
X-linked adrenoleukodystrophy (X-ALD) and pseudo neonatal adrenoleukodystrophy (P-NALD) are neurodegenerative demyelinating diseases resulting from the functional loss of the peroxisomal ATP-binding cassette transporter D (ABCD1) and from single peroxisomal enzyme deficiency (Acyl-CoA oxidase1: ACOX1), respectively. As these proteins are involved in the catabolism of very long chain fatty acids (VLCFA: C24:0, C26:0), X-ALD and P-NALD patients are characterized by the accumulation of VLCFA in plasma and tissues. Since peroxisomes are involved in the metabolism of reactive oxygen species (ROS) and nitrogen species (RNS), we examined the impact of VLCFA on the oxidative status of 158N murine o…
Increased susceptibility of microcytic red blood cells to in vitro oxidative stress.
1995
Oxidative damage to erythrocytes in thalassaemia has been related to generation of free radicals by an excess of denaturated alpha- or beta-globin chains, intracellular iron overload and low concentration of normal haemoglobin (HGB). Two good indicators of such oxidative damage are the high red blood cell (RBC) malonyldialdehyde (MDA) production detected following exogenous oxidant stress and the decrease of pyrimidine 5'-nucleotidase (P5N), the most sensitive enzyme to SH-group damage in vivo. Conflicting data, however, have so far accumulated in the literature concerning differences in oxidative damage between the different forms of thalassaemia and iron deficiency anaemia (IDA). In the p…
More Relevant Today Than Ever: Past, Present and Future of Media Performance Research
2020
Media performance is constitutive for functioning democracies. But what is the situation regarding media performance in the age of digitalisation? And how can media performance continue to be assured under the current difficult economic conditions for the news industry? In this essay, we give a short overview of how media performance research has developed from the introduction of private broadcasting to the spread of the Internet and social media. In the course of this development, the initial focus of media performance research on media content has broadened to include media quality from the user perspective. We show how the contributions to this thematic issue relate with existing lines …
Demokratie und Gemeinschaft. Oder: wie kontrovers ist die Kommunitarismusdebatte?
1996
"Unter dem Etikett der 'Kommunitarismusdebatte' wird seit einigen Jahren der Umgang mit Differenz und die Integration unterschiedlicher Bevölkerungsgruppen in ein demokratisches politisches System kontrovers diskutiert. Der Streit zwischen 'Kommunitaristen' und 'Liberalen' entzündet sich üaber die Grundlagen der modernen Demokratie. Vereinfacht gründet sich für die Kommunitaristen Demokratie zuerst auf Gemeinschaft und für die Liberalen zuerst auf Gerechtigkeit. Die Kommunitarismusdebatte blieb trotz einer großen Zahl von Beiträgen auf die Analyse moderner westlicher Demokratien beschränkt und sie weist zudem ein 'soziologisches Defizit' auf. Auf diese Lücken zielt meine Fragestellung. Wie …
Uso de metilprednisolona versus diclofenaco en el control de la inflamación y el trismo tras la cirugía del tercer molar inferior
2006
Objetivo: Comparar el efecto sobre la inflamación y el trismo de la metilprednisolona (corticoide) versus diclofenaco (antiinflamatorio no esteroideo-AINE-) tras la cirugía del tercer molar inferior. Diseño del estudio: Estudio prospectivo sobre 73 pacientes sometidos a la extracción quirúrgica de los terceros molares inferiores. Fueron divididos de forma aleatoria en dos grupos: De diclofenaco y de metilprednisolona. Se cumplimentó una ficha donde se hizo constar los datos epidemiológicos y clínicos preoperatorios y postoperatorios en relación a la inflamación y el trismo (tres medidas faciales y apertura bucal). Se usó el programa estadístico BMDP para hacer un amplio tratamiento de los d…
The role of small local history museums in creating digital heritage : the Finnish case
2017
The overall objective of this museological research is to investigate the role of small Finnish local heritage museums in creating digital heritage. The research aims are: (1) to provide a critical overview of virtual museums and digital heritage in the Finnish context, particularly in relation to small local history museums; (2) to bring attention to the potential of small museums in the area of digital heritage, and (3) to provide an insight into the shared qualities of digital heritage in small museums in Finland that can be used in future projects in the area of digital heritage in Finland. The research examines the following questions: (1) What are the qualities of the online services …
Asylum Migration, Borders, and Terrorism in a Structural Gravity Model
2021
This article has benefited from very helpful comments from two anonymous reviewers and the Academic Editor Inmaculada Martinez. The authors would like to acknowledge the financial support from Junta de Andalucia (SEJ 413), from Generalitat Valenciana (GV Prometeo 2018/102 and GV/2020/012), the Spanish Ministry of Science, Innovation and Universities (RTI2018-100899-B-I00, co-financed with FEDER), and the Kellogg Institute for International Studies (University of Notre Dame).
The Prevalence of Amblyopia in Germany
2015
Amblyopia is a condition in which reduced visual acuity is not directly caused by an organic defect (1). Amblyopia can develop when an infant or small child suffers from strabismus. Although both eyes are healthy, different images are formed on each fovea centralis (where vision is sharpest) and on other corresponding locations on the retina; this is in contrast to individuals without strabismus. To prevent double vision the child’s brain suppresses the image produced by one eye. Complete visual ability cannot develop in this eye during the sensitive phase of visual development (2). Approximately half of amblyopia cases (3) are caused by uncorrected higher refractive errors, which are frequ…
Sterigmatocystin-induced cytotoxicity via oxidative stress induction in human neuroblastoma cells.
2020
Abstract Sterigmatocystin (STE) is a mycotoxin produced by fungi of the genus Aspergillus. Considering that the effect of STE on neuronal system has not been well studied, the aim of the present study consists to investigate the cytotoxic effects of STE in human neuroblastoma (SH-SY5Y) cells. Moreover, the role of oxidative stress and intracellular defense systems was assessed by evaluating reactive oxygen species (ROS) generation, lipid peroxidation (LPO) and antioxidant no-enzymatic (GSH) levels and enzymatic (GPx, GST, CAT and SOD) activity. Our results revealed that STE decreased cell viability in a dose and time-dependent manner. Furthermore, after 24 h of exposure, STE induced an incr…
Identification of a Functional Homolog of the Yeast Copper Homeostasis Gene ATX1 from Arabidopsis1
1998
Abstract A cDNA clone encoding a homolog of the yeast (Saccharomyces cerevisiae) gene Anti-oxidant 1(ATX1) has been identified from Arabidopsis. This gene, referred to as CopperCHaperone(CCH), encodes a protein that is 36% identical to the amino acid sequence of ATX1 and has a 48-amino acid extension at the C-terminal end, which is absent from ATX1 homologs identified in animals. ATX1-deficient yeast (atx1) displayed a loss of high-affinity iron uptake. Expression of CCH in the atx1 strain restored high-affinity iron uptake, demonstrating thatCCH is a functional homolog of ATX1. When overexpressed in yeast lacking the superoxide dismutase geneSOD1, both ATX1 and CCHprotected the cell from t…