Search results for "ISOTOPES"
showing 10 items of 1216 documents
Exploring the boundaries of the nuclear landscape : α-decay properties of 211Pa
2020
Employing the recoil ion transport unit (RITU) and a fusion-evaporation reaction, the α decay of 211Pa has been identified via the implantation-decay correlation technique through observation of chains up to four consecutive decays. An α-particle energy and half-life of 8320(40) keV and 3.8+4.6−1.4 ms, respectively, were measured, corresponding to favored α decay. In addition, more precise α-decay properties of 212Pa and 213Pa were obtained due to accumulated statistics. The present data were compared to those predicted by selected atomic mass models and it was used to estimate the possibility of observing proton emission from these isotopes. peerReviewed
Response of microbial biomass and carbon dynamics to changing hydrological conditions in old peat deposits
2018
Peatlands play key roles in the global ecosystem carbon (C) balance, as important C-stores. Their efficiency as long-term C-stores or atmospheric C sink is affected by the rate of microbial mineralization. Most studies on the climate change effects on the microbial communities and C-cycling in peatlands have focused on the surface layers. This thesis compared microbial biomass, community composition and internal C cycling processes in drained vs. natural peat profiles with focus on deep old peat. Using the phospholipid fatty acid (PLFA) and rRNA gene analyses, the study particularly looked at the impact of long-term drainage and the short-term effects of temperature and water content on the…
Direct mass measurements on neutron-deficient xenon isotopes with the ISOLTRAP mass spectrometer
2002
The masses of Xe isotopes with 124 A 114 have been measured using the ISOLTRAP spectrometer at the on-line mass separator ISOLDE/CERN. A mass resolving power of 500000 was chosen resulting in an accuracy of m 12 keV for all isotopes investigated. Con icts with existing mass data of several standard deviations were found. peerReviewed
The influence of bacteria-dominated diets on Daphnia magna somatic growth, reproduction, and lipid composition
2012
We explored how dietary bacteria affect the life history traits and biochemical composition of Daphnia magna, using three bacteria taxa with very different lipid composition. Our objectives were to (1) examine whether and how bacteria-dominated diets affect Daphnia survival, growth, and fecundity, (2) see whether bacteria-specific fatty acid (FA) biomarkers accrued in Daphnia lipids, and (3) explore the quantitative relationship between bacteria availability in Daphnia diets and the amounts of bacterial FA in their lipids. Daphnia were fed monospecific and mixed diets of heterotrophic (Micrococcus luteus) or methanotrophic bacteria (Methylomonas methanica and Methylosinus trichosporium) and…
Evaluation of a novel monoclonal antibody against tumor-associated MUC1 for diagnosis and prognosis of breast cancer
2019
There is still a great unmet medical need concerning diagnosis and treatment of breast cancer which could be addressed by utilizing specific molecular targets. Tumor-associated MUC1 is expressed on over 90 % of all breast cancer entities and differs strongly from its physiological form on epithelial cells, therefore presenting a unique target for breast cancer diagnosis and antibody-mediated immune therapy. Utilizing an anti-tumor vaccine based on a synthetically prepared glycopeptide, we generated a monoclonal antibody (mAb) GGSK-1/30, selectively recognizing human tumor-associated MUC1. This antibody targets exclusively tumor-associated MUC1 in the absence of any binding to MUC1 on health…
16α-Iodo-3,17β-estradiol: A stable ligand for estrogen receptor determinations in tissues with high 17β-hydroxysteroid dehydrogenase activity
1983
Recently, the successful synthesis of radioiodinated 16 alpha-iodo-3,17 beta-estradiol-[125I] [125I]E2 was reported [1]. This new ligand has similar binding characteristics to the estrogen receptor (ER) [2-5] as the currently used tritium labeled estradiol [3H]E2. However, it offers several advantageous features: (a) high specific activity (theoretically 2,000 Ci/mmol) [1]; (b) minor problems with radioactive waste due to its short half life and (c) the possibility of simultaneous determination of ER and progesterone receptors (PgR) by double labeling with [125I]E2 and [3H]R5020 [6, 7]. As we are presently trying to determine ER and PgR in human placental cytosols we were interested in the …
Characterization of adenosine receptors in guinea-pig isolated left atria
1989
1. The effects of purinergic stimulation on action potential, force of contraction, 86Rb efflux and 45Ca uptake were investigated in guinea-pig left atria. 2. Adenosine exerted a negative inotropic effect which was antagonized by adenosine deaminase but enhanced by dipyridamole. 3. The negative inotropic effect of adenosine was mimicked by 5'-(N-ethyl)-carboxamido-adenosine (NECA) and the isomers of N6-(phenyl-isopropyl)-adenosine, R-PIA and S-PIA. NECA and R-PIA were about 100 times more potent than adenosine, whereas R-PIA was about 100 times more potent than S-PIA. 4. The inotropic effects of adenosine (in the presence of dipyridamole), NECA, R-PIA and S-PIA were competitively antagonize…
Prenatal diagnosis of mucolipidosis II (I-cell disease)
1976
A pregnancy at risk for mucolipidosis II (I-cell disease) was monitored in which an affected fetus was predicted on the basis of the analyses of lysosomal hydrolases in amniotic fluid and cultured amniotic fluid cells, and by the demonstration of an excessive accumulation of [35S] sulfate-labeled glycosaminoglycans in cultured amniotic cells. This diagnosis was confirmed by performing enzyme assays and [35S] sulfate incorporation studies on material derived from the aborted fetus.
Analysis of the hyperpolarizing effects of forskolin in guinea-pig atrial heart muscle.
1988
The effects of forskolin on action potential configuration and on both uptake and efflux of 86Rb+ were studied in guinea-pig left atria. The action potential was prolonged by forskolin in the plateau range but shortened at the end of repolarization; maximal upstroke velocity and amplitude of slow response potentials were enhanced. In partially depolarized preparations, the resting potential was increased by forskolin; this effect was not prevented by atropine 1 μmol/1. Forskolin augmented the rate constant of 86Rb+ efflux in beating and in resting preparations. The uptake of 86Rbs+ was enhanced by forskolin in resting preparations. It is concluded that forskolin stimulates the Na+, K+ -pump…
Klinisch-experimentelle Studie zur szintigraphischen Darstellung maligner Kopf-Hals-Neoplasien mit57Cobalt-Bleomycin
1975
Tumorscanning of malignomas and their metastatic nodules in head and neck is an enrichment of diagnostic possibilities. For the examination such substances can be used, which are tumoraffine and well to mark with a radio-isotope. Therefore we have marked the cytostatic drug Bleomycine with 57Co. Scans were performed with the Anger-Camera 4 to 6 hrs after intravenous injection of 1 mCi 57Co-Bleomycine. 60 patients with different malignomas have been examined, 46 with tumor-localization in head and neck, the others in thoraxabdomen. 34 (85%) of the head and neck malignomas could be demonstrated; 21 (81%) were squamous cell carcinomas, 13 (69%) sarcomas. The possibilities of this method are sh…