Search results for "ITS"
showing 10 items of 4946 documents
Toxicity of the antimalarial artemisinin and its dervatives.
2010
As long as no effective malaria vaccine is available, chemotherapy belongs to the most important weapons fighting malaria. One of the most promising new drug developments is the sesquiterpene artemisinin (ARS) and its derivatives, e.g., artemether, arteether, and sodium artesunate. Large clinical studies and meta-analyses did not show serious side effects, although proper monitoring of adverse effects in developing countries might not be a trivial task. There is a paucity of large-scale clinical trials suitable to detect rare but significant toxicity. Therefore, a final and definitive statement on the safety of artemisinins still cannot be made. In contrast, animal experiments show consider…
Immunopathogenesis of atherosclerosis: endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet.
2001
Background—On the basis of our concept that atherosclerosis has an immunopathological background, we tested whether activation of the innate immune system influences its progression.Methods and Results—Hypercholesterolemic (0.5% wt/wt diet) rabbits received either repeated intravenous injections of endotoxin (Escherichia colilipopolysaccharide 1.25 to 2.5 μg, once per week) or a self-limiting cutaneousStaphylococcus aureusinfection with or without a quinolone antibiotic. Measured laboratory parameters, including LDL and HDL cholesterols, were similar in the different groups of hypercholesterolemic animals. All endotoxin-treated animals developed transient episodes of fever after endotoxin a…
Clustering Quality and Topology Preservation in Fast Learning SOMs
2008
The Self-Organizing Map (SOM) is a popular unsupervised neural network able to provide effective clustering and data visualization for data represented in multidimensional input spaces. In this paper, we describe Fast Learning SOM (FLSOM) which adopts a learning algorithm that improves the performance of the standard SOM with respect to the convergence time in the training phase. We show that FLSOM also improves the quality of the map by providing better clustering quality and topology preservation of multidimensional input data. Several tests have been carried out on different multidimensional datasets, which demonstrate better performances of the algorithm in comparison with the original …
Some Personality Correlates of Business White-Collar Crime
2006
On presente dans cet article les resultats de la premiere etude transversale europeenne portant sur les dimensions de la personnalite en relation avec les delits financiers commis par les cols blancs. Ce travail est un prolongement de la recherche de Collin & Schmidt (1992) sur les delits des cols blancs aux Etats-Unis. Les donnees ont ete recoltees aupres de 150 cadres en poste dans des societes commerciales allemandes et de 76 delinquants en col blanc anciennement cadres. Les repondants ont rempli des echelles papier crayon mesurant l’hedonisme (l’Echelle de Valeurs de Schwartz), le sens des responsabilites (NEO-FFI), le narcissisme (DSM-III-R), la desirabilite sociale (Crowne & Marlowe),…
Le « reste à charge », participation du patient aux frais d'acquisition des produits de santé
2017
International audience
Search for eccentric binary black hole mergers with advanced LIGO and advanced Virgo during their first and second observing runs
2019
When formed through dynamical interactions, stellar-mass binary black holes may retain eccentric orbits ($e>0.1$ at 10 Hz) detectable by ground-based gravitational-wave detectors. Eccentricity can therefore be used to differentiate dynamically-formed binaries from isolated binary black hole mergers. Current template-based gravitational-wave searches do not use waveform models associated to eccentric orbits, rendering the search less efficient to eccentric binary systems. Here we present results of a search for binary black hole mergers that inspiral in eccentric orbits using data from the first and second observing runs (O1 and O2) of Advanced LIGO and Advanced Virgo. The search uses min…
An Indication of Anisotropy in Arrival Directions of Ultra-high-energy Cosmic Rays through Comparison to the Flux Pattern of Extragalactic Gamma-Ray …
2018
A new analysis of the dataset from the Pierre Auger Observatory provides evidence for anisotropy in the arrival directions of ultra-high-energy cosmic rays on an intermediate angular scale, which is indicative of excess arrivals from strong, nearby sources. The data consist of 5514 events above 20 EeV with zenith angles up to 80 deg recorded before 2017 April 30. Sky models have been created for two distinct populations of extragalactic gamma-ray emitters: active galactic nuclei from the second catalog of hard Fermi-LAT sources (2FHL) and starburst galaxies from a sample that was examined with Fermi-LAT. Flux-limited samples, which include all types of galaxies from the Swift-BAT and 2MASS …
Астрономия. Выпуск 19: Анализ движения небесных тел
1993
В статьях научных трудов представлены методы исследования движения и обработки результатов наблюдений тел Солнечной системы, а также способы управления и автоматизации процессов наблюдения небесных тел.
Femtolensing by dark matter revisited
2018
Femtolensing of gamma ray bursts (GRBs) has been put forward as an exciting possibility to probe exotic astrophysical objects with masses below $10^{-13}$ solar masses such as small primordial black holes or ultra-compact dark matter minihalos, made up for instance of QCD axions. In this paper we critically review this idea, properly taking into account the extended nature of the source as well as wave optics effects. We demonstrate that most GRBs are inappropriate for femtolensing searches due to their large sizes. This removes the previous femtolensing bounds on primordial black holes, implying that vast regions of parameter space for primordial black hole dark matter are not robustly con…
Speciālās izglītības skolotāja un fizioterapeita sadarbība pirmsskolas izglītības programmā bērniem ar somatiskām saslimšanām
2019
Darba nosaukums: „ Speciālas izglītības skolotāja un fizioterapeita sadarbība pirmsskolas izglītības programmā bērniem ar somatiskām saslimšanām” Darba autore: Santa Graudiņa Darba teorētiskajā daļā tiek analizēta un aprakstītas sadarbība izglītības iestādēs, izzinātas atbalsta komandas veidošanas pamatnostādnes, iepazītas speciāla izglītības skolotāja un fizioterapeita profesijas pamatnostādnes un šo speciālistu loma atbalsta komandas darbā, tika iepazītas somatiskās elpošanas slimības un to rehabilitācijas iespējas. Darba praktiskajā daļā darba autors apraksta savu pētniecisko darbību pirmsskolas izglītības iestādē, izveidotā elpošanas materiāla, vingrojumu kompleksa izmantošanu attīstoši…