Search results for "Ic testing"
showing 10 items of 283 documents
Why mammalian wound-healing researchers may wish to turn to Drosophila as a model.
2014
Wound healing is an essential and complex biological process that allows tissue continuity and functioning to be restored after injury. Understanding the molecular and cellular mechanisms underlying wound repair is essential to develop new therapies that could be useful not only to accelerate the normal healing process but also to treat healing pathologies that appear as a consequence of improper wound resolution. Numerous models have been developed to study wound healing both in vitro and in vivo. In vitro models have been useful to study some steps of epithelial repair. However, the development of effective treatments for wound healing is still required, and this could mainly be achieved …
Prediction model for aneuploidy in early human embryo development revealed by single-cell analysis.
2014
Aneuploidies are prevalent in the human embryo and impair proper development, leading to cell cycle arrest. Recent advances in imaging and molecular and genetic analyses are postulated as promising strategies to unveil the mechanisms involved in aneuploidy generation. Here we combine time-lapse, complete chromosomal assessment and single-cell RT–qPCR to simultaneously obtain information from all cells that compose a human embryo until the approximately eight-cell stage (n=85). Our data indicate that the chromosomal status of aneuploid embryos (n=26), including those that are mosaic (n=3), correlates with significant differences in the duration of the first mitotic phase when compared with e…
Towards Automatic Testing of Reference Point Based Interactive Methods
2016
In order to understand strengths and weaknesses of optimization algorithms, it is important to have access to different types of test problems, well defined performance indicators and analysis tools. Such tools are widely available for testing evolutionary multiobjective optimization algorithms. To our knowledge, there do not exist tools for analyzing the performance of interactive multiobjective optimization methods based on the reference point approach to communicating preference information. The main barrier to such tools is the involvement of human decision makers into interactive solution processes, which makes the performance of interactive methods dependent on the performance of huma…
Some Features of Modeling Ultrasound Propagation in Non-Destructive Control of Metal Structures Based on the Magnetostrictive Effect
2023
A method and mathematical models of direct and inverse problems of ultrasonic testing and diagnostics of complex metal structures for defects were developed and tested. A prototype of a system for magnetostrictive control of elements of the objects under study was manufactured and experimentally tested. Mathematical simulation of ultrasonic testing processes using MATLAB and the COMSOL Multiphysics software environment was carried out. The adequacy of the mathematical models was verified by the results of their comparison with real physical experiments. Information support and a methodology that implements it was developed, which ensure the functioning of the control facilities for these ob…
Simulation of laser-generated ultrasonic wave propagation in solid media and air with application to NDE
2009
Ultrasonic methods are well known as powerful and reliable tool for defect detection. In the previous decades focus and interest have been directed to non-contact sensors and methods, showing many advantages over contact techniques where inspection depends on contact conditions (pressure, coupling medium, contact area). The non-contact hybrid ultrasonic method described here is of interest for many applications, requiring periodic inspection in service or after manufacturing. Despite the potential impact of laser-generated ultrasound in many areas of industry, robust tools for studying the phenomenon are lacking and thus limit the design and optimization of non-destructive testing and evalu…
No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Data…
2021
Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers of pathogenic changes in mismatch repair (MMR) genes have an increased risk of developing colorectal (CRC), endometrial, ovarian, urinary tract, prostate, and other cancers, depending on which gene is malfunctioning. In Lynch syndrome, differences in cancer incidence (penetrance) according to the gene involved have led to the stratification of cancer surveillance. By contrast, any differences in penetrance determined by the type of pathogenic variant remain unknown. Objective. To determine cumulative incidences of cancer in carriers of truncating and missense or aberrant splicing pathogenic …
Predicting needlestick and sharps injuries in nursing students: Development of the SNNIP scale
2020
© 2020 The Authors. Nursing Open published by John Wiley & Sons Ltd. Aim: To develop an instrument to investigate knowledge and predictive factors of needlestick and sharps injuries (NSIs) in nursing students during clinical placements. Design: Instrument development and cross-sectional study for psychometric testing. Methods: A self-administered instrument including demographic data, injury epidemiology and predictive factors of NSIs was developed between October 2018–January 2019. Content validity was assessed by a panel of experts. The instrument's factor structure and discriminant validity were explored using principal components analysis. The STROBE guidelines were followed. Results: E…
O início de uma nova era: teste sistemático para patógenos causadores de infecções agudas das vias aéreas superiores (IVAS) em crianças
2007
On average humans get sick ten times per year. About six times the illness is due to an acute respiratory tract infection (ARI). Morbidity is especially high in children since they usually encounter the offending organism for the first time in their life; the lack of immunity results in shedding of the offending organisms in high numbers of prolonged time as compared to adults; their airways are smaller than those of adults and thus the inflammatory response leads to a more significant narrowing of the airways resulting in more severe disease; on average they have a high number of social contacts and also a more intimate contact with peers and caregivers alike resulting in a higher attack r…
Influence of Menstrual Cycle or Hormonal Contraceptive Phase on Physiological Variables Monitored During Treadmill Testing
2021
Purpose: To examine the influence of menstrual cycle (MC) and hormonal contraceptive (HC) cycle phases on physiological variables monitored during incremental treadmill testing in physically active women (eumenorrheic, EUM = 16 and monophasic HC-users, CHC = 12). Methods: Four running tests to exhaustion were performed at bleeding, mid follicular (mid FOL)/active 1, ovulation/active 2, and mid luteal (mid LUT)/inactive. HC and MC phases were confirmed from serum hormones. Heart rate (HR), blood lactate (Bla), and VO˙ 2 were monitored, while aerobic (AerT) and anaerobic (AnaT) thresholds were determined. VO˙ 2peak, maximal running speed (RUNpeak), and total running time (RUNtotal) were recor…
A case study on the evaluation of friction stir welds by ultrasonic inspection technique
2015
Friction stir welding (FSW) is an innovative process that has been successfully used in joining aluminum alloys, normally difficult to weld. Important advantages over fusion welding are better retention of baseline material properties, lower residual stresses and excellent mechanical properties. Defects that occur in FSW joints are due to improper tooling or setup. Non-destructive techniques used to inspect FSW joints are X-rays, eddy current, conventional ultrasonic testing and dye penetrant proper only for surface breaking defects. Currently there is no non-destructive technique that can guarantee absence of flaws in friction welds during manufacturing. In this work, non-destructive remot…