Search results for "Identity"

Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin.

2020

Erythropoietin (EPO), named after its role in hematopoiesis, is also expressed in mammalian brain. In clinical settings, recombinant EPO treatment has revealed a remarkable improvement of cognition, but underlying mechanisms have remained obscure. Here, we show with a novel line of reporter mice that cognitive challenge induces local/endogenous hypoxia in hippocampal pyramidal neurons, hence enhancing expression of EPO and EPO receptor (EPOR). High-dose EPO administration, amplifying auto/paracrine EPO/EPOR signaling, prompts the emergence of new CA1 neurons and enhanced dendritic spine densities. Single-cell sequencing reveals rapid increase in newly differentiating neurons. Importantly, i…

2018

Sex differences in lifespan are ubiquitous, but the underlying causal factors remain poorly understood. Inter- and intrasexual social interactions are well known to influence lifespan in many taxa, but it has proved challenging to separate the role of sex-specific behaviours from wider physiological differences between the sexes. To address this problem, we genetically manipulated the sexual identity of the nervous system—and hence sexual behaviour—in Drosophila melanogaster , and measured lifespan under varying social conditions. Consistent with previous studies, masculinization of the nervous system in females induced male-specific courtship behaviour and aggression, while nervous system…

Minors and Transexuality

2020

[ES] En el ámbito de la transexualidad los poderes públicos han ejercido desde un principio una política claramente restrictiva que ha requerido de años para poder abrirse a las nuevas necesidades y a la sociedad actual. Así, la normativa en la materia era totalmente excluyente de los menores de edad, considerándolos carentes de aptitud alguna para poder decidir sobre su identidad sexual y todo lo que ello conllevaba, quizá porque como afirman algunos autores “la finalidad básica de esa prohibición es la de garantizar que la decisión de la rectificación registral sea una decisión firme y coherente, evitando así cambios arbitrarios o no fundados en el sexo” (Vázquez-Pastor, 2010).Esta idea p…

Proposed minimal standards for the use of genome data for the taxonomy of prokaryotes

2018

Advancement of DNA sequencing technology allows the routine use of genome sequences in the various fields of microbiology. The information held in genome sequences proved to provide objective and reliable means in the taxonomy of prokaryotes. Here, we describe the minimal standards for the quality of genome sequences and how they can be applied for taxonomic purposes.

Inner Archipelagos in Sicily. From Culture-Based Development to Creativity-Oriented Evolution

2020

When Covid-19 arrived in Europe from the far East, the media and experts in economics and social sciences noticed that it was the expected discontinuity in the socio-economic development process. Really, the current phase has spread since the 1960s, when the application of econometric worldwide-spread development model was going to produce social inequalities, and consumption of physical, social, and cultural resources. Some places in Italy, far from the erosive and urban context and erosive metropolitan areas, are currently isolated seeds of a new cycle of life, because of the local community identity and the strong link between human, cultural, and natural components are currently working…

Evaluating Cell Identity from Transcription Profiles

2018

SummaryInduced pluripotent stem cells (iPS) and direct lineage programming offer promising autologous and patient-specific sources of cells for personalized drug-testing and cell-based therapy. Before these engineered cells can be widely used, it is important to evaluate how well the engineered cell types resemble their intended target cell types. We have developed a method to generate CellScore, a cell identity score that can be used to evaluate the success of an engineered cell type in relation to both its initial and desired target cell type, which are used as references. Of 20 cell transitions tested, the most successful transitions were the iPS cells (CellScore > 0.9), while other t…

Impact of the Gender Identity Law in Argentinean transgender women

2017

Background: In May 2012, collective efforts led to the enactment of a Gender Identity Law in Argentina. This is a particularly progressive law, based on human rights principles, as it is the first ...

‘Celebrating diverse motherhood’: physically disabled women’s counter-narratives to their stigmatised identity as mothers

2018

This study examined how disabled women negotiated their stigmatised identity as mothers by presenting counter-narratives to the culturally dominant narrative of disabled motherhood. Eleven Finnish physically disabled mothers were interviewed. The data were analysed by focusing on these counter-narratives, their linguistic features and their functions in the interviews. The disabled mothers produced four types of counter-narratives about their motherhood experiences: (1) celebrating diverse motherhood through individual coping; (2) performing motherhood through collaborative caring; (3) boosting motherhood through praising one’s children; and (4) normalising (disabled women’s) motherhood thr…

Language teacher identities as socio-politically situated construction: Finnish and Brazilian student teachers’ visualisations of their professional …

2021

Abstract The process of envisioning the future is central to teachers’ identity construction, but different environments create distinct sociocultural conditions for the process. This qualitative study drawing on visual-textual methods compares Finnish and Brazilian student teachers’ desired and feared professional futures. Two different perspectives on future identities were detected: a desire for status and a desire for meaningfulness. The results revealed the radically different social status of teaching in the two countries and the role this played in the envisioned identities. The study highlights the importance of awareness of the socio-political nature of identity construction in dev…

Place and space in home-making processes and the construction of identities in transnational migration

2016

AbstractIn this era of increasing migration and the trend of growing social, political, and cultural integration worldwide, it is questionable whether the concept of home in its traditional meaning still applies or has to be redefined. Many social scientists agree that the mobile individual of the twenty-first century has become uprooted and thus disoriented or that the idea of home has lost its significance. Since home is still closely tied to one’s identity, the current discussions on the construction of identity must also be incorporated in the analytical processes of home-making. The objective is to point out new ways of understanding the idea of home by taking into consideration and an…