Search results for "Ilici"
showing 10 items of 238 documents
Effect of ionization and the nature of the mobile phase in quantitative structure-retention relationship studies.
2005
Abstract The octanol–water distribution constant, commonly called partition coefficient, Po/w, is a parameter often retained as a measure of the hydrophobicity of a molecule. log Po/w, for a given molecule, can be conveniently evaluated constructing correlation lines between standard retention factor logarithms (log k) in reversed-phase liquid chromatography (RPLC) and standard log Po/w values. Many compounds of pharmaceutical interest can be quite hydrophobic and have, simultaneously, basic nitrogen atoms or acidic sulfur containing groups in their structure. This renders them ionizable. The hydrophobicity of the molecular drug form (Po/w value) is completely different from its ionic form …
Stranded jellyfish in the lowermost Cambrian (Corduban) of Spain
2021
Ninety discoid structures of big size occurring on a bedding plane of Nemakit-Daldynian to Tommotian sandstones (i.e. Corduban in the Spanish scale of Cambrian stages) from south-western Spain are described. Cross-cutting relationships between discoid structures and associated trace fossils, as well as evidence for penecontemporaneous deformation of sediment laminae below the discoids, permit to interprete these structures as impressions of ancient, soft-bodied marine organisms. Taphonomic, biometric, and morphological studies suggest that they are outer moulds of both sides, subumbrellar and exumbrellar, of ancient jellyfish of hydrozoan coelenterates, whose canals resemble the modern genu…
The Dark Trienium: Valencia, 1389-1391. Unrest coinciding with an assault on the Jewish district
2012
Estudio de base documental sobre el auge del antijudaísmo desde 1371 y el asalto a la judería de Valencia en julio de 1391, al poco tiempo de su ampliación. Sitúa el hecho en el contexto de las tensiones políticas en la Corona de Aragón y en la ciudad, donde se enfrentaban sendos bandos: actuaciones entre 1375 y 1392 del inquisidor Nicolau Eimeric (Directorium inquisitorum) contra herejes y su condena de obras de Ramon Llull. Cortes de 1388-1389. Guerras en el ámbito pirenaico en 1390. Políticas de abastecimiento y defensa de la ciudad de Valencia y oposición de villas y nobles del reino al municipio de la capital, que arma una milicia montada en mayo de 1391. Represión de maleantes y medid…
Phytosociological characterization of the Juniperus phoenicea L. subsp. turbinata (Guss.) Nyman formations in the Italo-Tyrrhenian Province (Mediterr…
2012
The Juniperus phoenicea subsp. turbinata formations of the Italo-Tyrrhenian biogeographical province (Mediterranean Region), are analyzed on the basis of literature data and unpublished relevés. The floristic-synecological characterization of the identified phytocoenoses, confirmed by multivariate analysis on a synoptic basis, has allowed their breakdown in four different alliances of the order Pistacio lentisci-Rhamnetalia alaterni: 1) Periplocion angustifoliae, with the association Periploco angustifoliae-Juniperetum turbinatae; 2) Juniperion turbinatae, with the associations Junipero turbinatae-Quercetum calliprini, Rusco aculeati-Quercetum calliprini, Phillyreo angustifoliae-Juniperetum…
La milicia ciudadana de la Valencia medieval
2006
La persecución de malhechores en la ciudad de Valencia durante la Edad Media correspondió a un magistrado municipal, el Justicia, que desarrollaba funciones policiales y militares. La comandancia de la ronda urbana permitía la represión de la delincuencia, mientras que el caudillaje de la milicia ciudadana convocaba en armas a los vecinos para hacer frente a las agresiones materiales y jurídicas que pudiera sufrir el municipio. La milicia servía tanto para la defensa militar como para garantizar los poderes jurisdiccionales con los que la monarquía había dotado a la ciudad. The persecution of malefactors in the city of Valencia in the Middle Age corresponded a municipal magistrate, the Just…
New trepostomate bryozoans from the Upper Ordovician of Morocco and the temperature influence on zooid size
2015
AbstractNew Upper Ordovician trepostomate bryozoans from the eastern Anti-Atlas of Morocco have been identified. They have been collected from the lower and intermediate units of the Khabt-el-Hajar Formation, late Katian in age, representing, respectively, bryozoan-pelmatozoan meadows with siliciclastic input, degraded by wave activity in a mid-ramp setting, and outer-ramp environments with marly substrates. Ten species of the generaCyphotrypa,Calloporella,Diplotrypa,Parvohallopora,Dekayia, andAostiporaare described. Of them, three species are new:Cyphotrypa regularisJiménez-Sánchez,Parvohallopora cystataJiménez-Sánchez, andAostipora elongataJiménez-Sánchez. Univariate statistical analyses …
The youngest Trigoniida (Mollusca, Bivalvia) of Europe, including new genera and species from the type area of the Maastrichtian Stage
2022
Until recently, only a single species of trigoniid bivalve was known from the upper Maastrichtian Maastricht Formation in the type area of the Maastrichtian Stage (south-east Netherlands and adjacent Belgian and German territories); it was named Trigonia maestrichtiana by Alphonse Briart in 1888. This common, rather small species is here transferred to the genus Oistotrigonia, and a lectotype is designated. In addition, two new genera of very small rutitrigoniids, Wolfgangella and Anniedhondtella, and three new species, W. neilpearti, W. ignota and A. rieui, are erected. Most of the material available is preserved as (paired) external and internal moulds in a nearshore facies of indurated b…
Validation of a biophysical drug absorption model by the PATQSAR system
1999
Absorption rate constants (in situ rat gut technique) and in vitro antibacterial activities of twenty fluoroquinolones have been evaluated. A biophysical model that relates the absorption of the compounds with their lipophilicity was fitted. The model considers the absorption process from the intestinal lumen as the sum of two resistances in series: aqueous diffusional barrier and lipoidal membrane. Even if partitioning into the membrane and membrane diffusion are both enhanced for lipophilic compounds, the absorption rate constant is limited by the aqueous diffusion. To estimate the influence of structural modifications on each property and to establish the role of lipophilicity in control…
A novel approach to determining physicochemical and absorption properties of 6-fluoroquinolone derivatives: experimental assessment
2002
The ToSS MoDe approach is used to estimate the n-octanol/buffer partition coefficient, the apparent intestinal absorption rate constant and intestinal permeability from a 6-fluoroquinolone data set. Improved in silico methods for predicting a drug's ability to be transported across biological membranes and other biopharmaceutical properties is highly desirable to optimize new drug development. The physicochemical property (Log P) of 26 6-fluoroquinolone derivatives and the absorption properties (Log K(a) and Log P(eff)) of 21 derivatives were well described by the present approach. The models obtained confirm the important role of lipophilicity in the absorption process and its relation wit…
Studies on the reliability of a bihyperbolic functional absorption model. II. Phenylalkylamines
1987
Evidence is given that demonstrates the reliability of the bihyperbolic equation, proposed by Pla-Delfina and Moreno, in fitting the correlation between absorption rate constants (ka) found in the small intestine and in the colon of the living anesthetized rat, and partition constants (1/R.F−1), for a series of phenylalkylamines, a group of compounds which differ largely from others which have been tested. Emphasis is laid on the nonexistence of an optimum of lipophilicity for intestinal absorption/partition correlation: This feature makes inapplicable the probabilistic approaches to the reported data.