6533b82bfe1ef96bd128cdfa
RESEARCH PRODUCT
Studies on the reliability of a bihyperbolic functional absorption model. II. Phenylalkylamines
A. Martín-villodreEsperanza Núñez-benitoElena Miralles-loyolaAna Martínez-coscolláJ.m. Plá-delfinaVicente G. Casabósubject
MaleBenzylaminesPsychotropic DrugsAniline CompoundsPropylaminesSeries (mathematics)ChemistryStereochemistryThermodynamicsRats Inbred StrainsButylaminesModels BiologicalIntestinal absorptionRatsAbsorption rateIntestinal AbsorptionColonic absorptionPhenethylaminesLipophilicityAnimalsPartition (number theory)Pharmacology (medical)General Pharmacology Toxicology and PharmaceuticsAbsorption (chemistry)Reliability (statistics)description
Evidence is given that demonstrates the reliability of the bihyperbolic equation, proposed by Pla-Delfina and Moreno, in fitting the correlation between absorption rate constants (ka) found in the small intestine and in the colon of the living anesthetized rat, and partition constants (1/R.F−1), for a series of phenylalkylamines, a group of compounds which differ largely from others which have been tested. Emphasis is laid on the nonexistence of an optimum of lipophilicity for intestinal absorption/partition correlation: This feature makes inapplicable the probabilistic approaches to the reported data.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1987-12-01 | Journal of Pharmacokinetics and Biopharmaceutics |