Search results for "Immediate"
showing 10 items of 175 documents
Immediatezza, incidente probatorio, usura probatoria, art. 238 bis c.p.p.
2015
Lo studio ha per oggetto l'assetto della prova penale nei processi di criminalità organizzata alla luce delle numerose deroghe ai principi di acquisizione della prova. In particolare viene focalizzata l'attenzione sulle deroghe al principio di immediatezza con l'estensione dei casi di incidente probatorio e della c.d. circolazione probatoria, sebbene con i temperamenti susseguenti alla legge attuativa sul giusto processo. L'approccio è di tipo critico in quanto la fisionomia disegnata in origine e poi modificata rimane ancora oggi sfigurata rispetto alle linee tracciate dal 'codice Vassalli'.
Macrophages Escape Inhibition of Major Histocompatibility Complex Class I-Dependent Antigen Presentation by Cytomegalovirus
2000
ABSTRACTThe mouse cytomegalovirus (MCMV)m152- andm06-encoded glycoproteins gp40 and gp48, respectively, independently downregulate major histocompatibility complex (MHC) class I surface expression during the course of productive MCMV infection in fibroblasts. As a result, presentation of an immediate-early protein pp89-derived nonapeptide toH-2Ld-restricted CD8+cytotoxic T cells is completely prevented in fibroblasts. Here we demonstrate that MCMV-infected primary bone marrow macrophages and the macrophage cell line J774 constitutively present pp89 peptides during permissive MCMV infection to cytotoxic T lymphocytes (CTL). In contrast to fibroblasts, expression of them152andm06genes in macr…
Enrichment of Immediate-Early 1 (m123/pp89) Peptide-Specific CD8 T Cells in a Pulmonary CD62LloMemory-Effector Cell Pool during Latent Murine Cytomeg…
2000
ABSTRACTInterstitial cytomegalovirus (CMV) pneumonia is a clinically relevant complication in recipients of bone marrow transplantation (BMT). Recent data for a model of experimental syngeneic BMT and concomitant infection of BALB/c mice with murine CMV (mCMV) have documented the persistence of tissue-resident CD8 T cells after clearance of productive infection of the lungs (J. Podlech, R. Holtappels, M.-F. Pahl-Seibert, H.-P. Steffens, and M. J. Reddehase, J. Virol. 74:7496–7507, 2000). It was proposed that these cells represent antiviral “standby” memory cells whose functional role might be to help prevent reactivation of latent virus. The pool of pulmonary CD8 T cells was composed of two…
Tristetraprolin Regulates the Expression of the Human Inducible Nitric-Oxide Synthase Gene
2005
The expression of human inducible NO synthase (iNOS) is regulated both by transcriptional and post-transcriptional mechanisms. Stabilization of mRNAs often depends on activation of p38 mitogen-activated protein kinase (p38 MAPK). In human DLD-1 cells, inhibition of p38 MAPK by the compound 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole (SB203580) or by overexpression of a dominant-negative p38 MAPKalpha protein resulted in a reduction of human iNOS mRNA and protein expression, whereas human iNOS promoter activity was not affected. An important RNA binding protein regulated by the p38 MAPK pathway and involved in the regulation of the stability of several mRNAs is tr…
Immediate Loading with Fixed Full-Arch Prosthesis in the Edentulous Patient: Treatment Protocol
2019
Immediate loading is basically a prosthetic concept. However, the surgical implantological planning is very important to ensure a primary stability in the total edentulous patient. This characteristic is crucial to allow immediate loading in this type of patients. For the first time, the incisional design has allowed the clinician to overview about the surgical side. Later, maybe, the bone will need an osteoplasty to regularize possible bone defects. To ensure primary stability, it can use methods to enhance primary stability as undersized drilling technique and use of osteotomes and bi-cortical anchorage implants. There are two main protocols to obtain temporary immediate loading full-arch…
Introduction to Immediate Loading in Implantology
2019
Branemark traditional recommendation was to perform implant rehabilitation in two stages: the first entry was only for implant placement; after 3–6 months of undisturbed submerged healing for mandible and maxilla, respectively, a second surgical entry would have allowed loading of the implants. The rationale behind this approach was that implant micro-movements as consequence by an inadequate primary stability, caused by functional forces at the bone-implant interface in the early wound healing stages, could have induced fibrous tissue formation rather than new bone, eventually causing clinical failure. The main request was to reduce the overall rehabilitation time from surgery to final res…
Guided Surgery and Immediate Loading
2019
Computer-assisted implant dentistry can contribute for a better treatment planning, for the implementation of the implant placement, for capturing the intraoral situation, for processing data to design temporary and final prostheses, and for the manufacturing of prosthetic components.
Implant insertion torque value in immediate loading : a retrospective study
2019
Background The aim of this study is to verify if the Insertion Torque Value (ITV) of 32 Ncm for immediate loading protocol (ILP), as indicated by literature, is still, with the advance in implant research, a real significant cut-off for long-term implant survival. Material and Methods In this retrospective study, data from 224 patients that during three years of clinical practice, were submitted to the insertion of 322 implants with immediate loading protocol, have been recorded, pooled and analyzed. Data were organized based on Insertion Torque Value (ITV): > 32 Ncm (CG) and 32 Ncm are still characterized by a lower crestal bone resorption, there are no statistically significant difference…
Resistance of keratinocytes to TGFbeta-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds.
2002
The pleiotropic growth factor TGFβ plays an important role in regulating responses to skin injury. TGFβ targets many different cell types and is involved in all aspects of wound healing entailing inflammation,re-epithelialization, matrix formation and remodeling. To elucidate the role of TGFβ signal transduction in keratinocytes during cutaneous wound healing, we have used transgenic mice expressing a dominant negative type II TGFβ receptor exclusively in keratinocytes. We could demonstrate that this loss of TGFβ signaling in keratinocytes led to an accelerated re-epithelialization of full thickness excisional wounds accompanied by an increased proliferation in keratinocytes at the wound ed…
Random, asynchronous, and asymmetric transcriptional activity of enhancer-flanking major immediate-early genes ie1/3 and ie2 during murine cytomegalo…
2001
ABSTRACT The lungs are a major organ site of cytomegalovirus (CMV) pathogenesis, latency, and recurrence. Previous work on murine CMV latency has documented a high load and an even distribution of viral genomes in the lungs after the resolution of productive infection. Initiation of the productive cycle requires expression of the ie1/3 transcription unit, which is driven by the immediate-early (IE) promoter P 1/3 and generates IE1 and IE3 transcripts by differential splicing. Latency is molecularly defined by the absence of IE3 transcripts specifying the essential transactivator protein IE3. In contrast, IE1 transcripts were found to be generated focally and randomly, reflecting sporadic P …