Search results for "Immunity"

Chronic Spontaneous Urticaria in Patients with Common Variable Immunodeficiency

2018

Common variable immunodeficiency (CVID) is a predominantly antibody deficiency and is one of the most common primary immunodeficiencies in adulthood. Replacement therapy with Ig has significantly reduced infectious complications; however, malignant, autoimmune, and inflammatory diseases are still current major causes of morbidity and mortality. In recent years, interest has increased regarding allergic manifestations that may be associated with primary immunodeficiencies; however, no data are currently available on chronic spontaneous urticaria (CSU). In this report, the authors describe CSU in patients with CVID attending their centre. Three CVID patients were affected by CSU and were unre…

Effect of inter-individual variability and intraguild interferences on the foraging strategies of seed-eating carabid species

2017

Making a choice requires, implicitly, an investment of time in one behaviour at the expense of an investment in another. Being choosy would increase the risk of losing many food item opportunities to competitors, and is directly in conflict with other essential tasks such as predator avoidance. Individuals are thus expected to adjust their level of choosiness in response to the competition and predation context. The available behavioural ecological theory and the empirical ecology of carabids would suggest that competition and predation interference induces changes in the foraging behaviour of carabid individuals. Carabids typically operate within communities in which competition and predat…

Towards digital cognitive clones for the decision-makers: adversarial training experiments

2021

Abstract There can be many reasons for anyone to make a digital copy (clone) of own decision-making behavior. This enables virtual presence of a professional decision-maker simultaneously in many places and processes of Industry 4.0. Such clone can be used as one’s responsible representative when the human is not available. Pi-Mind (“Patented Intelligence”) is a technology, which enables “cloning” cognitive skills of humans using adversarial machine learning. In this paper, we present a cyber-physical environment as an adversarial learning ecosystem for cloning image classification skills. The physical component of the environment is provided by the logistic laboratory with camera-surveilla…

Taxonomy of generative adversarial networks for digital immunity of Industry 4.0 systems

2021

Abstract Industry 4.0 systems are extensively using artificial intelligence (AI) to enable smartness, automation and flexibility within variety of processes. Due to the importance of the systems, they are potential targets for attackers trying to take control over the critical processes. Attackers use various vulnerabilities of such systems including specific vulnerabilities of AI components. It is important to make sure that inappropriate adversarial content will not break the security walls and will not harm the decision logic of critical systems. We believe that the corresponding security toolset must be organized as a trainable self-protection mechanism similar to immunity. We found cer…

Molecular characterization of macrophage migration inhibitory factor (MIF) from mussel, Mytilus galloprovincialis

2012

Cetacean Morbillivirus: Current Knowledge and Future Directions

2014

We review the molecular and epidemiological characteristics of cetacean morbillivirus (CeMV) and the diagnosis and pathogenesis of associated disease, with six different strains detected in cetaceans worldwide. CeMV has caused epidemics with high mortality in odontocetes in Europe, the USAand Australia. It represents a distinct species within the Morbillivirusgenus. Although most CeMV strains are phylogenetically closely related, recent data indicate that morbilliviruses recovered from Indo-Pacific bottlenose dolphins (Tursiops aduncus), from Western Australia, and a Guiana dolphin (Sotalia guianensis), from Brazil, are divergent. The signaling lymphocyte activation molecule (SLAM) cell rec…

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

2013

At mucosal surfaces, the immune system should not initiate inflammatory immune responses to the plethora of antigens constantly present in the environment, but should remain poised to unleash a potent assault on intestinal pathogens. The transcriptional programs and regulatory factors required for immune cells to switch from homeostatic (often tissue-protective) function to potent antimicrobial immunity are poorly defined. Mucosal retinoic-acid-receptor-related orphan receptor-γt-positive (RORγt(+)) innate lymphoid cells (ILCs) are emerging as an important innate lymphocyte population required for immunity to intestinal infections. Various subsets of RORγt(+) ILCs have been described but th…

O início de uma nova era: teste sistemático para patógenos causadores de infecções agudas das vias aéreas superiores (IVAS) em crianças

2007

On average humans get sick ten times per year. About six times the illness is due to an acute respiratory tract infection (ARI). Morbidity is especially high in children since they usually encounter the offending organism for the first time in their life; the lack of immunity results in shedding of the offending organisms in high numbers of prolonged time as compared to adults; their airways are smaller than those of adults and thus the inflammatory response leads to a more significant narrowing of the airways resulting in more severe disease; on average they have a high number of social contacts and also a more intimate contact with peers and caregivers alike resulting in a higher attack r…

Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19

2021

To understand how a protective immune response against SARS-CoV-2 develops over time, we integrated phenotypic, transcriptional and repertoire analyses on PBMCs from mild and severe COVID-19 patients during and after infection, and compared them to healthy donors (HD). A type I IFN-response signature marked all the immune populations from severe patients during the infection. Humoral immunity was dominated by IgG production primarily against the RBD and N proteins, with neutralizing antibody titers increasing post infection and with disease severity. Memory B cells, including an atypical FCRL5+ T-BET+ memory subset, increased during the infection, especially in patients with mild disease. A…

The endopolygalacturonase 1 from botrytis cinerea activates grapevine defense reactions unrelated to its enzyumatic activity

2003

A purified glycoprotein from Botrytis cinerea(strain T4), identified as endopolygalacturonase 1 (T4BcPG1) by mass spectrometry analysis, has been shown to activate defense reactions in grapevine (Vitis vinifera cv. Gamay). These reactions include calcium influx, production of active oxygen species, activation of two mitogen-activated protein kinases, defense gene transcript accumulation, and phytoalexin production. Most of these defense reactions were also activated in grapevine in response to purified oligogalacturonides (OGA) with a degree of polymerization of 9 to 20. In vivo, these active OGA might be a part of the released products resulting from endopolygalacturonase activity on plan…