Search results for "Imprinting"

OPALINE: Observatory of food preferences in infants and children

2010

Acceptation of novel dietary flavours by infants after exposure to flavour in mother’s milk

2010

Périodes et facteurs sensibles pour la formation précoce des préférences alimentaires

2015

Eating behavior is a complex, essentially learned activity critical for development and survival. It can be broken down into several components: when, how, what and how much to eat.1,2 We will mainly describe in this chapter the important periods and factors associated with the development of “what” to eat, or in other words, food preferences and choice. Other aspects relevant to the early development of eating behavior have been previously reviewed.2,3 Although it has previously been shown that food and flavor preference may be influenced by flavor exposure during the prenatal period4-6, we will focus in this chapter on the acquisition of food preferences consecutive to direct exposure of …

Pheromonal imprinting in Drosophila melanogaster: preadult exposure affects free flight odor tracking in adult

2021

International audience

2015

AbstractGenomic imprinting is implicated in the control of gene dosage in neurogenic niches. Here we address the importance of Igf2 imprinting for murine adult neurogenesis in the subventricular zone (SVZ) and in the subgranular zone (SGZ) of the hippocampus in vivo. In the SVZ, paracrine IGF2 is a cerebrospinal fluid and endothelial-derived neurogenic factor requiring biallelic expression, with mutants having reduced activation of the stem cell pool and impaired olfactory bulb neurogenesis. In contrast, Igf2 is imprinted in the hippocampus acting as an autocrine factor expressed in neural stem cells (NSCs) solely from the paternal allele. Conditional mutagenesis of Igf2 in blood vessels co…

Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis

2015

Genomic imprinting is implicated in the control of gene dosage in neurogenic niches. Here we address the importance of Igf2 imprinting for murine adult neurogenesis in the subventricular zone (SVZ) and in the subgranular zone (SGZ) of the hippocampus in vivo. In the SVZ, paracrine IGF2 is a cerebrospinal fluid and endothelial-derived neurogenic factor requiring biallelic expression, with mutants having reduced activation of the stem cell pool and impaired olfactory bulb neurogenesis. In contrast, Igf2 is imprinted in the hippocampus acting as an autocrine factor expressed in neural stem cells (NSCs) solely from the paternal allele. Conditional mutagenesis of Igf2 in blood vessels confirms t…

Cytosensing of cancer cells using antibody-based molecular imprinting: A short-review

2018

Abstract Rapid and effective differentiation between normal and cancer cells is an important objective for the diagnosis, prognosis and theranosis of tumors. This short review highlights some of the most recent developments on the application of molecular bioimprinting in detection of cancer cells using antibody-based cancer cell recognition method. The particular emphasis of this review is on sample-to-answer devices and approaches that enable down-stream investigation of the properties of the cells. Given the speed, portability, sensitivity and selectivity achieved using molecular bioimprinting technology on cancer cell monitoring, these methods hold the promise of transformative change i…

Water-compatible molecularly imprinted polymers obtained via high-throughput synthesis and experimental design.

2003

A technique allowing high-throughput synthesis and evaluation of molecularly imprinted polymer sorbents at a reduced scale (mini-MIPs) was developed and used for the optimization of MIPs for use in pure aqueous environments. The technique incorporated a 4-port liquid-handling robot for the rapid dispensing of monomers, templates, solvents and initiator into the reaction vessels of a 96-well plate. A library of 80 polymers, each ca. 50 mg, could thus be prepared in 24 h. The MIP rebinding capacity and selectivity could be rapidly assessed in the batch mode by quantifying nonbound fractions in parallel using a UV monochromator plate reader. This allowed a complete evaluation of the binding ch…

Noncovalent molecular imprinting: antibody-like molecular recognition in polymeric network materials

1997

Abstract Molecular imprinting techniques allow the preparation of polymeric receptors which bind small molecules with affinities and selectivities of the same order as those observed in the binding of antigens by antibodies. The molecular imprinting technology has now reached a stage where the commercial use of imprinted materials is being assessed, notably for separations requiring strong and selective binding of small molecules. This development is driven by the potential advantages of polymeric receptors over biological in terms of stability, capacity, cost and ease of preparation. In this short review the state of the art of noncovalent imprinting is summarised indicating a few areas in…

Influence of the pH on the behavior of an imprinted polymeric stationary phase--supporting evidence for a binding site model.

2001

The equilibrium isotherms of the two enantiomers of phenylalanine anilide (PA) were measured by conventional frontal analysis at three different pH on a thermally-treated imprinted stationary phase selective for the L enantiomer. The first of these pH (buffer pH=3.0, pH(app)=4.0) is well below the apparent pKa (6.4) of the two solutes, the second (buffer pH=5.8, pH(app)=7.0) slightly below this pKa, and the third (buffer pH=7.0, pH(app)=8.3) well above it. The experimental data were fitted to several isotherm models. The best estimates of the parameters of these models are reported and discussed. The corresponding isotherms are compared with the experimental ones. The contributions of the e…