Search results for "Individu"

Targeting the tumor mutanome for personalized vaccination therapy

2012

Next generation sequencing enables identification of immunogenic tumor mutations targetable by individualized vaccines. In the B16F10 melanoma system as pre-clinical proof-of-concept model, we found a total of 563 non-synonymous expressed somatic mutations. Of the mutations we tested, one third were immunogenic. Immunization conferred in vivo tumor control, qualifying mutated epitopes as source for effective vaccines.

Tumor Heterogeneity, Single-Cell Sequencing, and Drug Resistance

2016

Tumor heterogeneity has been compared with Darwinian evolution and survival of the fittest. The evolutionary ecosystem of tumors consisting of heterogeneous tumor cell populations represents a considerable challenge to tumor therapy, since all genetically and phenotypically different subpopulations have to be efficiently killed by therapy. Otherwise, even small surviving subpopulations may cause repopulation and refractory tumors. Single-cell sequencing allows for a better understanding of the genomic principles of tumor heterogeneity and represents the basis for more successful tumor treatments. The isolation and sequencing of single tumor cells still represents a considerable technical ch…

Stil' kak vyzov

2016

In the meta-theoretical framework, a full scientific theory is a complex hierarchical-network structure which covers three levels: 1) a set of ontological, epistemological-methodological and axiological assumptions (the philosophical basis of a theory); 2) a set of highly abstract theoretical notions and general theorems which compose the image of the world; 3) a set of notions and descriptive theorems which assert something directly about the object being examined (the empirical part). The author considers the first two levels of the full theory of style, i.e., he focuses on its philosophical part and chooses the notion of subject from the second level. He accepts, as the starting point, h…

Studio di un dosimetro individuale per la misura delle variazioni temporali di intensità di campo magnetico in RM

2009

Interdiction des poursuites individuelles. Une instance en référé tendant au paiement d'une provision n'est pas une instance en cours interrompue par…

2019

International audience; (Com. 19 sept. 2018, n° 17-13.210, F-P+B, Sté Les Séréniales c/ Sté AJS, D. 2018. 1862 ; RJDA 2018, n° 926)

Activation-Induced Rigidity in Neurologically and Cognitively Healthy Individuals Aged 18-90 Years: A Cross-Sectional Study.

2021

Background: Rigidity is a key clinical feature of Parkinson’s disease (PD), but in a very early phase of the disease it may be absent and can be enhanced through active movements of the arm contralateral to the one being tested. Objective: To evaluate in a large cohort of neurologically and cognitively healthy (NCH) subjects aged 18–90 years if activation-induced rigidity (AR) is present in all age classes, and if there are biological differences between subjects showing AR (AR+) and not showing AR (AR-). Methods: 2,228 NCH subjects categorized as young adult (18–44 years), adult (45–64 years), elderly (65–74 years), and old/oldest-old (75–90 years) were included in the analysis, and underw…

Teachers' visual focus of attention in relation to students' basic academic skills and teachers' individual support for students: An eye-tracking stu…

2022

This study investigated how teachers' visual focus of attention is associated with students' basic academic skills and teachers' individual support for students in basic academic skills in authentic classroom settings. Teachers' (N = 46) visual focus of attention in the classroom was measured with mobile eye-tracking, and students' (N = 879) literacy and math skills were tested in Grade 1. The results revealed that teachers' visual focus of attention in terms of fixation counts correlated with students' basic academic skills and teachers' individual support for students in literacy and math. Two case studies showed that teachers' visual focus of attention varied among students with differen…

Study of the accretion torque during the 2014 outburst of the X-ray pulsar GRO J1744−28

2017

We present the spectral and timing analysis of the X-ray pulsar GRO J1744-28 during its 2014 outburst using data collected with the X-ray satellites Swift, INTEGRAL, Chandra, and XMM-Newton. We derived, by phase-connected timing analysis of the observed pulses, an updated set of the source ephemeris. We were also able to investigate the spin-up of the X-ray pulsar as a consequence of the accretion torque during the outburst. Relating the spin-up rate and the mass accretion rate as $\dot{\nu}\propto\dot{M}^{\beta}$, we fitted the pulse phase delays obtaining a value of $\beta=0.96(3)$. Combining the results from the source spin-up frequency derivative and the flux estimation, we constrained …

AE Aurigae: First detection of non-thermal X-ray emission from a bow shock produced by a runaway star

2012

Runaway stars produce shocks when passing through interstellar medium at supersonic velocities. Bow shocks have been detected in the mid-infrared for several high-mass runaway stars and in radio waves for one star. Theoretical models predict the production of high-energy photons by non-thermal radiative processes in a number sufficiently large to be detected in X-rays. To date, no stellar bow shock has been detected at such energies. We present the first detection of X-ray emission from a bow shock produced by a runaway star. The star is AE Aur, which was likely expelled from its birthplace due to the encounter of two massive binary systems and now is passing through the dense nebula IC 405…

Skolēnu ar dzirdes traucējumiem iekļaušanas problēmas un risinājumi vispārizglītojošā skolā

2021

Bakalaura darbs ir izstrādāts par tēmu “Skolēnu ar dzirdes traucējumiem iekļaušanas problēmas un risinājumi vispārizglītojošā skolā”. Bakalaura darba autore: Jekaterina Dzinēja Darba izvēlētā temata aktualitāte pamatojama ar to, ka mūsdienās skolēni ar dzirdes traucējumiem tiek iekļauti vispārizglītojošajās skolās, pedagogi un vecāki sastopas ar dažāda rakstura problēmām iekļaujot skolēnus ar dzirdes traucējumiem vispārizglītojošajās skolās, tādēļ būtiski izpētīt intervējot skolotājus un vecākus kā var atrisināt šīs problēmas. Pētījuma mērķis: Veikt teorētisku un praktisku pētījumu par skolēnu ar dzirdes traucējumiem iekļaušanas vispārizglītojošajā skolā problēmām un to risinājumiem, izmant…