Search results for "Infant"
showing 10 items of 3339 documents
Hereditary combined deficiency of the vitamin K-dependent clotting factors
2010
Abstract Hereditary combined vitamin K-dependent clotting factors deficiency (VKCFD) is a rare congenital bleeding disorder resulting from variably decreased levels of coagulation factors II, VII, IX and X as well as natural anticoagulants protein C, protein S and protein Z. The spectrum of bleeding symptoms ranges from mild to severe with onset in the neonatal period in severe cases. The bleeding symptoms are often life-threatening, occur both spontaneously and in a surgical setting, and usually involve the skin and mucosae. A range of non-haemostatic symptoms are often present, including developmental and skeletal anomalies. VKCFD is an autosomal recessive disorder caused by mutations in …
Projekt komputu armii litewskiej z 1703 r. wraz z podziałem na poszczególne chorągwie i regimenty
2017
W niniejszym artykule zostaje wprowadzone do obiegu naukowego nowe źródło do badań nad historią armii litewskiej w okresie wielkiej wojny północnej (1700–1721), którym jest projekt komputu z 1703 r. Znajduje się on w Bibliotece Kórnickiej Polskiej Akademii Nauk w rękopisie o sygnaturze 985. W inwentarzu rękopisów biblioteki widnieje natomiast jako komput z 1706 r. Trudno jednak ustalić faktyczną datę jego powstania. Możliwe jest jedynie oszacowanie pewnych cezur. Sporządzony został na pewno przed 27 listopada 1703 r. (wprowadzenie w życie postanowień rady senatu w Jaworowie o pozbawieniu urzędów Sapiehów). Natomiast prawdopodobnie powstał przed lub w trakcie sejmu lubelskiego (11 czerwca – …
Impact of a minimally processing route for the production of infant formulas on the organoleptic properties
2022
Many new-borns are fed with substitutes of breast milk. These products undergo several heat treatments, necessary to insure their microbiologic safety but probably modifying their organo-leptic properties. High temperature can damage milk proteins and form Maillard reaction prod-ucts with lactose. Microfiltration – to replace the heat treatments for a milk debacterization – combined with a soft spray-drying is currently an alternative little exploited to produce infant formulas (IFs) although microbiologically safe. The aim of this study was to determine the im-pact of such processing route on the organoleptic properties of the IFs. Three experimental IFs were manufactured at a semi-industr…
Mosaic activating mutations in GNA11 and GNAQ are associated with phakomatosis pigmentovascularis and extensive dermal melanocytosis
2016
Common birthmarks can be an indicator of underlying genetic disease but are often overlooked. Mongolian blue spots (dermal melanocytosis) are usually localized and transient, but they can be extensive, permanent, and associated with extracutaneous abnormalities. Co-occurrence with vascular birthmarks defines a subtype of phakomatosis pigmentovascularis, a group of syndromes associated with neurovascular, ophthalmological, overgrowth, and malignant complications. Here, we discover that extensive dermal melanocytosis and phakomatosis pigmentovascularis are associated with activating mutations in GNA11 and GNAQ, genes that encode Gα subunits of heterotrimeric G proteins. The mutations were det…
WWOX-related encephalopathies: delineation of the phenotypical spectrum and emerging genotype-phenotype correlation
2014
International audience; BACKGROUND:Homozygous mutations in WWOX were reported in eight individuals of two families with autosomal recessive spinocerebellar ataxia type 12 and in two siblings with infantile epileptic encephalopathy (IEE), including one who deceased prior to DNA sampling.METHODS:By combining array comparative genomic hybridisation, targeted Sanger sequencing and next generation sequencing, we identified five further patients from four families with IEE due to biallelic alterations of WWOX.RESULTS:We identified eight deleterious WWOX alleles consisting in four deletions, a four base-pair frameshifting deletion, one missense and two nonsense mutations. Genotype-phenotype correl…
Didáctica (lengua y literatura)
2017
La diversidad siempre ha estado presente en nuestro alumnado, no obstante, la incorporación de culturas poco presentes en España, fue un revulsivo en los años 90 para la revitalización de la educación intercultural. Pero a nuestro parecer, existe una carencia importante de estudios acerca de cómo esta nueva multiculturalidad ha hecho mella en la sociedad, y en especial en los materiales no curriculares entre los cuales la Literatura Infantil y Juvenil (LIJ) es un componente fundamental. Es importante, pues, y necesario comprobar qué tratamiento se ha hecho de la multiculturalidad en la LIJ y el estereotipo es, sin duda, uno de los aspectos más sensibles que se reflejan en las obras.Nuestro …
Sialic acid (N-acetyl and N-glycolylneuraminic acid) and ganglioside in whey protein concentrates and infant formulae
2011
Abstract Sialic acid and gangliosides content and profiles were analyzed in infant formulae, whey protein concentrates and human milk. In infant formulae, N-acetylneuraminic (Neu5Ac) and N-glycolylneuraminic (Neu5Gc) acid ranged from 147.6–199.7 to 3.3–8.3 mg L −1 , in whey protein concentrate from 1.6–2.4 g 100 g −1 to 2.8–20.2 mg 100 g −1 and in human milk from 299.9 to 2.1 mg L −1 . Gangliosides ranged from 0.25 to 2.29 mg lipid-bound sialic acid L −1 in reconstituted infant formula, the main gangliosides being GD 3 (73.3–55.5%), GM 3 (3.5–36.6%) and GT 3 (1.4–14.1%) and O-acetyl-GD 3 (5.3–18.9%). In whey protein concentrates, 0.7–55.6 mg lipid-bound sialic acid 100 g −1 were found with …
Booster vaccination after neonatal priming with acellular pertussis vaccine.
2010
After a birth dose of acellular pertussis (aP) and diphtheria (DT)aP-hepatitis B virus (HBV)-inactivated polio vaccine (IPV)/ Haemophilus influenza type b (Hib) at 2, 4, and 6 months, a booster dose of DTaP-HBV-IPV/Hib at 12 to 23 months induced strong anti-pertussis booster responses. Thus, neonatal aP priming did not lead to immune tolerance to pertussis antigens. However, it elicited bystander interference on HBV, Hib, and diphtheria responses.
ACELLULAR PERTUSSIS VACCINE COMPOSED OF GENETICALLY INACTIVATED PERTUSSIS TOXIN: SAFETY AND IMMUNOGENICITY IN 12- TO 24- AND 2-TO 4-MONTH-OLD CHILDREN
1992
To determine whether a nontoxic derivative of pertussis toxin obtained by recombinant DNA technology, PT-9K/129G, is a good candidate for a new pertussis vaccine, we examined the safety and the immunogenicity in children of a vaccine containing 15 micrograms of PT-9K/129G protein and 0.5 mg of aluminum hydroxide per dose. Fifty-three children 12 to 24 months of age and 21 infants aged 2 to 4 months were injected with two and three doses, respectively. The vaccine did not induce significant local or systemic reactions and elicited an increase of antibody titer in more than 98% of the children. The geometric mean of the toxin-neutralizing titers increased after each dose and was 85 units in c…
MEMORIA DE TRABAJO EN NIÑOS DE EDUCACIÓN INFANTIL CON Y SIN BAJO RENDIMIENTO MATEMÁTICO
2014
Abstract:This study aims to explore working memory in preschool children with and without low mathematical performance. The sample consisted of 255 children aged 5-6 years, to whom were administered neuropsychological tests of working memory and TEDI-MATH to estimate the mathematical performance. The results highlight the capacity of verbal working memory to significantly differentiate groups of children with and without problems in 8 of the 9 analyzed mathematical domains. This factor together with visuospatial working memory differentiate the group of children at risk for mathematical learning disabilities.Keywords: working memory, preschool, math performance, mathematics learning disabil…