Search results for "Influenza A viru"

showing 10 items of 78 documents

Trends of influenza B during the 2010–2016 seasons in 2 regions of north and south Italy: The impact of the vaccine mismatch on influenza immunisatio…

2017

Influenza A and B viruses are responsible for respiratory infections, representing globally seasonal threats to human health. The 2 viral types often co-circulate and influenza B plays an important role in the spread of infection. A 6-year retrospective surveillance study was conducted between 2010 and 2016 in 2 large administrative regions of Italy, located in the north (Liguria) and in the south (Sicily) of the country, to describe the burden and epidemiology of both B/Victoria and B/Yamagata lineages in different healthcare settings. Influenza B viruses were detected in 5 of 6 seasonal outbreaks, exceeding influenza A during the season 2012–2013. Most of influenza B infections were found…

Male0301 basic medicinevirusesInfluenza B viruDisease OutbreaksHuman health0302 clinical medicineRetrospective StudieEpidemiologyImmunology and Allergy030212 general & internal medicinehospitalChildSicilyB/Victoriaeducation.field_of_studyDisease OutbreakVaccinationvirus diseasesB/Victoria; B/Yamagata; community; hospital; Influenza type B; lineage; vaccine-mismatch; Immunology and Allergy; Immunology; Pharmacologyvaccine-mismatchInfluenza type BInfluenza A viruInfluenza A virusInfluenza VaccinesChild PreschoolcommunityCommunity settingFemaleSeasonsInfluenza VaccineHumanResearch Papermedicine.medical_specialty030106 microbiologyImmunologyPopulationEpidemic03 medical and health sciencesInfluenza HumanmedicineHumansEpidemicseducationRetrospective StudiesPharmacologyInfluenza immunisationbusiness.industryOutbreakInfluenza aVirologyInfluenza B virusVaccine mismatchSeasonbusinessB/YamagatalineageDemographyHuman Vaccines & Immunotherapeutics
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Incidence rates of narcolepsy diagnoses in Taiwan, Canada, and Europe: The use of statistical simulation to evaluate methods for the rapid assessment…

2018

Vacunación; Narcolepsia; Simulación y modelado: en Vacunació; Narcolèpsia; Simulació i modelització Vaccination; Narcolepsy; Simulation and modeling Background & objectives Vaccine safety signals require investigation, which may be done rapidly at the population level using ecological studies, before embarking on hypothesis-testing studies. Incidence rates were used to assess a signal of narcolepsy following AS03-adjuvanted monovalent pandemic H1N1 (pH1N1) influenza vaccination among children and adolescents in Sweden and Finland in 2010. We explored the utility of ecological data to assess incidence of narcolepsy following exposure to pandemic H1N1 virus or vaccination in 10 sites that use…

Male:Other subheadings::Other subheadings::/epidemiology [Other subheadings]medicine.medical_treatmentlcsh:Medicine:Other subheadings::Other subheadings::/drug therapy [Other subheadings]medicine.disease_causeGeographical locations:enfermedades del sistema nervioso::trastornos del sueño-vigilia::disomnias::trastornos intrínsecos del sueño::trastornos de somnolencia excesiva::narcolepsia [NarcolepsiaENFERMEDADES]Influenza A Virus H1N1 Subtype0302 clinical medicineRisk FactorsPandemicMedicine and Health SciencesInfluenza A virusMedicinePublic and Occupational Health030212 general & internal medicineYoung adultChildlcsh:Science:Otros calificadores::Otros calificadores::/tratamiento farmacológico [Otros calificadores]Aged 80 and overVaccinesMultidisciplinaryIncidenceSimulation and ModelingIncidence (epidemiology)Vaccination:Otros calificadores::Otros calificadores::/epidemiología [Otros calificadores]Middle AgedVaccination and ImmunizationEuropeVaccinationInfectious DiseasesNeurologyInfluenza VaccinesChild PreschoolsymbolsEngineering and TechnologyFemaleSafetyNarcolèpsia - TractamentAdjuvantResearch ArticleAdultCanadaAsiaAdolescentInfectious Disease ControlImmunologyTaiwanResearch and Analysis MethodsYoung Adult03 medical and health sciencessymbols.namesakeAdjuvants ImmunologicEnvironmental healthInfluenza HumanHumansComputer SimulationEuropean UnionPoisson regressionAgedTrastorns del sonNarcolepsySwedenModels Statisticalbusiness.industrylcsh:RInfant NewbornNarcolèpsia - EpidemiologiaInfantBiology and Life SciencesDyssomniasAge GroupsR - MedicineRelative riskSignal ProcessingPopulation Groupingslcsh:QPreventive MedicinePeople and placesSleep Disordersbusiness030217 neurology & neurosurgeryPLOS ONE
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SARS CoV2 infection _The longevity study perspectives

2021

Graphical abstract

MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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Transmission of hemagglutinin D222G mutant strain of pandemic (H1N1) 2009 virus.

2010

A pandemic (H1N1) 2009 virus strain carrying the D222G mutation was identified in a severely ill man and was transmitted to a household contact. Only mild illness developed in the contact, despite his obesity and diabetes. The isolated virus reacted fully with an antiserum against the pandemic vaccine strain.

MaleEpidemiologyvirusesMutantResistancelcsh:MedicineHemagglutinin Glycoproteins Influenza VirusSettore MED/42 - Igiene Generale E Applicatamedicine.disease_causeSeverity of Illness IndexDisease Outbreakschemistry.chemical_compoundInfluenza A Virus H1N1 SubtypePandemicInfluenza A virusA/H1N1PhylogenyTransmission (medicine)H1N1DispatchtransmissionMiddle AgedInfectious DiseasesD222GItalyInfluenza A virusRNA ViralinfluenzaMicrobiology (medical)AdultOseltamivirMutation MissenseHemagglutinin (influenza)BiologyViruslcsh:Infectious and parasitic diseasesMicrobiologyOseltamivirInfluenza HumanmedicineHumanslcsh:RC109-216virusesRetrospective StudiesAntiserumSequence Analysis RNApandemiclcsh:RMutantVirologyInfluenzaH1N1 subtypechemistryAmino Acid Substitutionbiology.proteinA/H1N1vmutationInfluenza; A/H1N1v; Oseltamivir; ResistanceEmerging infectious diseases
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Factors Associated with Influenza Vaccination of Hospitalized Elderly Patients in Spain

2016

Vaccination of the elderly is an important factor in limiting the impact of influenza in the community. The aim of this study was to investigate the factors associated with influenza vaccination coverage in hospitalized patients aged ≥ 65 years hospitalized due to causes unrelated to influenza in Spain. We carried out a cross-sectional study. Bivariate analysis was performed comparing vaccinated and unvaccinated patients, taking in to account sociodemographic variables and medical risk conditions. Multivariate analysis was performed using multilevel regression models. We included 1038 patients: 602 (58%) had received the influenza vaccine in the 2013-14 season. Three or more general practit…

MaleEstudios transversalesGripeAncianoEspañaGripPneumococcal VaccinesElderlyPatient Education as TopicInfluenza HumanHumansVacunacióPacientsVacunació -- EspanyaAgedAged 80 and overVaccinesInpatientsMarital StatusVaccinationVacunaciónPneumonia PneumococcalInfluenzaCross-Sectional StudiesStreptococcus pneumoniaeSocial ClassGeriatricsSpainInfluenza A virusInfluenza VaccinesVaccination and immunizationFemaleAge groups
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No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity

2015

Garcia-Etxebarria, Koldo et al.

MaleGenotypeRisk factors in diseaseslcsh:MedicineGenome-wide association studySingle-nucleotide polymorphismDiseaseBiologyBioinformaticsmedicine.disease_causePolymorphism Single NucleotideSeverity of Illness IndexGripInfluenza A Virus H1N1 SubtypeGene FrequencyRisk FactorsGenotypeSeverity of illnessInfluenza HumanInfluenza A virusmedicineSNPHumanslcsh:ScienceAllele frequencyMultidisciplinaryFactors de risc en les malaltieslcsh:RGenomicsInfluenzaGenòmicaEstudi de casosRNA ViralRNAFemalelcsh:QCase studiesResearch Article
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Effectiveness of hand hygiene and provision of information in preventing influenza cases requiring hospitalization☆☆☆★

2012

Background The objective of the study was to investigate the effectiveness of non-pharmacological interventions in preventing cases of influenza requiring hospitalization. Methods We performed a multicenter case-control study in 36 hospitals, in 2010 in Spain. Hospitalized influenza cases confirmed by reverse-transcription polymerase chain reaction and three matched controls (two hospital and one community control) per case were selected. The use of non-pharmacological measures seven days before the onset of symptoms (frequency of hand washing, use of alcohol-based hand sanitizers and handwashing after touching contaminated surfaces) was collected. Results We studied 813 cases hospitalized …

MaleHandwashingNon-pharmacological measuresEpidemiologyPsychological interventionInfluenza A Virus H1N1 SubtypeHygieneRisk FactorsEpidemiologyChildmedia_commonTransmission (medicine)Reverse Transcriptase Polymerase Chain ReactionMiddle AgedHospitalizationChild PreschoolFemaleHand DisinfectionAdultmedicine.medical_specialtyHand washingAdolescentmedia_common.quotation_subjectCase control studyHealth PromotionAdministration CutaneousArticleHand sanitizerInfluenza HumanmedicineTransmissionHumansIntensive care medicineInfection Controlbusiness.industryPreventionPublic Health Environmental and Occupational HealthCase-control studyInfant NewbornInfantOdds ratioInfluenzaSocial ClassSpainCase-Control StudiesEmergency medicineAnti-Infective Agents LocalbusinessHand hygieneDisinfectantsPreventive Medicine
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Molecular surveillance of pandemic influenza A(H1N1) viruses circulating in Italy from May 2009 to February 2010: association between haemagglutinin …

2010

Haemagglutinin sequences of pandemic influenza A(H1N1) viruses circulating in Italy were examined, focusing on amino acid changes at position 222 because of its suggested pathogenic relevance. Among 169 patients, the D222G substitution was detected in three of 52 (5.8%) severe cases and in one of 117 (0.9%) mild cases, whereas the D222E mutation was more frequent and evenly distributed in mild (31.6%) and severe cases (38.4%). A cluster of D222E viruses among school children confirms reported human-to-human transmission of viruses mutated at amino acid position 222.

MaleMolecular surveillance; Pandemic influenza A(H1N1); Haemagglutinin mutations; Italy from May 2009 to February 2010pandemic influenzasurveillance of pandemic influenza A(H1N1); Molecular surveillance; pandemic influenzaEpidemiologyvirusesHaemagglutinin mutationssurveillance of pandemic influenza A(H1N1)Settore MED/42 - Igiene Generale E Applicatamedicine.disease_causeSeverity of Illness IndexInfluenza A Virus H1N1 SubtypePandemic influenza A(H1N1)PandemicInfluenza A VirusA(H1N1)ChildMutationReverse Transcriptase Polymerase Chain ReactionTransmission (medicine)Adolescent; Adult; Age Distribution; Aged; Amino Acid Substitution; Child; Child Preschool; Female; Hemagglutinins; Humans; Infant; Influenza A Virus H1N1 Subtype; Influenza Human; Italy; Male; Middle Aged; Mutation; Population Surveillance; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Sex Distribution; Young Adult; PandemicsMiddle AgedItaly from May 2009 to February 2010Molecular surveillance; pandemic influenza; A(H1N1); Italy; haemagglutinin mutationsHemagglutininsMolecular surveillanceItalyChild PreschoolPopulation SurveillanceFemaleHumanAdultAdolescentBiologyDisease clusterDisease courseYoung AdultAge DistributionVirologyInfluenza HumanmedicineHumansH1N1 SubtypeSex DistributionPreschoolhaemagglutinin mutationsPandemicsAgedMolecular epidemiologyPublic Health Environmental and Occupational HealthPandemic influenzaInfantVirologyInfluenzaMutational analysisAmino Acid SubstitutionMutationEurosurveillance
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Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19

2020

Abstract: BackgroundProgressive respiratory failure is the primary cause of death in the coronavirus disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of the disease, relatively little is known about the associated morphologic and molecular changes in the peripheral lung of patients who die from Covid-19. MethodsWe examined 7 lungs obtained during autopsy from patients who died from Covid-19 and compared them with 7 lungs obtained during autopsy from patients who died from acute respiratory distress syndrome (ARDS) secondary to influenza A(H1N1) infection and 10 age-matched, uninfected control lungs. The lungs were studied with the use of seven-color immun…

MalePathologymedicine.medical_specialtyAngiogenesisPneumonia ViralAutopsy030204 cardiovascular system & hematologyNeovascularizationBetacoronavirus03 medical and health sciencesInfluenza A Virus H1N1 Subtype0302 clinical medicineInfluenza HumanmedicineHumans030212 general & internal medicineLungPandemicsAgedCause of deathAged 80 and overRespiratory Distress SyndromeNeovascularization PathologicSARS-CoV-2business.industryCOVID-19ThrombosisGeneral MedicineMiddle Agedmedicine.diseaseThrombosisPathophysiology3. Good healthPneumoniaFemaleAutopsyEndothelium VascularHuman medicinemedicine.symptomCoronavirus InfectionsRespiratory InsufficiencybusinessHuman PathologyThe New England journal of medicine
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Surveillance Data for Eight Consecutive Influenza Seasons in Sicily, Italy

2019

Influenza A and B outbreaks occur each year with different activity and molecular patterns. To date, knowledge of seasonal epidemiology remains a prerequisite not only to put in place the most effective immunization strategy against influenza but also to identify population groups at higher risk of developing serious complications. A retrospective analysis of influenza surveillance data from 2010 to 2018 aimed to explore the epidemiology of influenza in Sicily, at the primary care and hospital level. Overall, 6,740 patients with acute respiratory infection were tested, of which 3,032 (45.0%) were positive for influenza. The relative proportion of type A and B viruses markedly varied across …

MalePediatricsCommunityDiseaseSettore MED/42 - Igiene Generale E ApplicataSeverity of Illness IndexDisease Outbreakslaw.inventionRisk FactorslawEpidemiologyChildRespiratory Tract InfectionsSicilyeducation.field_of_studyVaccinationRespiratory infectionArticlesMiddle AgedIntensive care unitHospitalizationIntensive Care UnitsInfectious DiseasesMolecular surveillanceInfluenza A virusChild PreschoolEpidemiological MonitoringFemaleSeasonsAdultmedicine.medical_specialtyAdolescentPopulationYoung AdultVirologyInfluenza HumanmedicineHumanseducationAgedRetrospective Studiesbusiness.industryInfantOutbreakmedicine.diseaseObesityInfluenzaInfluenza B virusImmunizationParasitologyRisk factorbusinessThe American Journal of Tropical Medicine and Hygiene
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