Search results for "Information and Computing Sciences"
showing 8 items of 18 documents
sj-pdf-1-jis-10.1177_01655515211043708 – Supplemental material for How do gender, Internet activity and learning beliefs predict sixth-grade students…
2021
Supplemental material, sj-pdf-1-jis-10.1177_01655515211043708 for How do gender, Internet activity and learning beliefs predict sixth-grade students’ self-efficacy beliefs in and attitudes towards online inquiry? by Eero Sormunen, Norbert Erdmann, Suzanne CSA Otieno, Mirjamaija Mikkilä-Erdmann, Eero Laakkonen, Teemu Mikkonen, Md Arman Hossain, Roberto González-Ibáñez, Mario Quintanilla-Gatica, Paavo HT Leppänen and Marja Vauras in Journal of Information Science
sj-pdf-1-jis-10.1177_01655515211043708 – Supplemental material for How do gender, Internet activity and learning beliefs predict sixth-grade students…
2021
Supplemental material, sj-pdf-1-jis-10.1177_01655515211043708 for How do gender, Internet activity and learning beliefs predict sixth-grade students’ self-efficacy beliefs in and attitudes towards online inquiry? by Eero Sormunen, Norbert Erdmann, Suzanne CSA Otieno, Mirjamaija Mikkilä-Erdmann, Eero Laakkonen, Teemu Mikkonen, Md Arman Hossain, Roberto González-Ibáñez, Mario Quintanilla-Gatica, Paavo HT Leppänen and Marja Vauras in Journal of Information Science
PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins
2020
Abstract The Protein Ensemble Database (PED) (https://proteinensemble.org), which holds structural ensembles of intrinsically disordered proteins (IDPs), has been significantly updated and upgraded since its last release in 2016. The new version, PED 4.0, has been completely redesigned and reimplemented with cutting-edge technology and now holds about six times more data (162 versus 24 entries and 242 versus 60 structural ensembles) and a broader representation of state of the art ensemble generation methods than the previous version. The database has a completely renewed graphical interface with an interactive feature viewer for region-based annotations, and provides a series of descriptor…
Cross-species transcriptomic analysis elucidates constitutive aryl hydrocarbon receptor activity
2014
Background Research on the aryl hydrocarbon receptor (AHR) has largely focused on variations in toxic outcomes resulting from its activation by halogenated aromatic hydrocarbons. But the AHR also plays key roles in regulating pathways critical for development, and after decades of research the mechanisms underlying physiological regulation by the AHR remain poorly characterized. Previous studies identified several core genes that respond to xenobiotic AHR ligands across a broad range of species and tissues. However, only limited inferences have been made regarding its role in regulating constitutive gene activity, i.e. in the absence of exogenous ligands. To address this, we profiled transc…
Quantifying the Potential Economic Benefits of Flexible Industrial Demand in the European Power System
2018
The envisaged decarbonization of the European power system introduces complex techno-economic challenges to its operation and development. Demand flexibility can significantly contribute in addressing these challenges and enable a cost-effective transition to the low-carbon future. Although extensive previous work has analyzed the impacts of residential and commercial demand flexibility, the respective potential of the industrial sector has not yet been thoroughly investigated despite its large size. This paper presents a novel, whole-system modeling framework to comprehensively quantify the potential economic benefits of flexible industrial demand (FID) for the European power system. This …
New insights into the regulatory mechanisms of ppGpp and DksA on Escherichia coli RNA polymerase-promoter complex
2015
The stringent response modulators, guanosine tetraphosphate (ppGpp) and protein DksA, bind RNA polymerase (RNAP) and regulate gene expression to adapt bacteria to different environmental conditions. Here, we use Atomic Force Microscopy and in vitro transcription assays to study the effects of these modulators on the conformation and stability of the open promoter complex (RPo) formed at the rrnA P1, rrnB P1, its discriminator (dis) variant and lambda pR promoters. In the absence of modulators, RPo formed at these promoters show different extents of DNA wrapping which correlate with the position of UP elements. Addition of the modulators affects both DNA wrapping and RPo stability in a promo…
CNN-Based Prostate Zonal Segmentation on T2-Weighted MR Images: A Cross-Dataset Study
2020
Prostate cancer is the most common cancer among US men. However, prostate imaging is still challenging despite the advances in multi-parametric magnetic resonance imaging (MRI), which provides both morphologic and functional information pertaining to the pathological regions. Along with whole prostate gland segmentation, distinguishing between the central gland (CG) and peripheral zone (PZ) can guide toward differential diagnosis, since the frequency and severity of tumors differ in these regions; however, their boundary is often weak and fuzzy. This work presents a preliminary study on deep learning to automatically delineate the CG and PZ, aiming at evaluating the generalization ability o…
Benefits and drawbacks of communication visibility : from vicarious learning and supplemental work to knowledge reuse and overload
2022
Purpose This study aims to examine some of the benefits and drawbacks of communication visibility. Specifically, building on communication visibility theory, the authors study how and why message transparency and network translucence may increase knowledge reuse and perceived overload through behavioral responses of vicarious learning and technology-assisted supplemental work. Design/methodology/approach Drawing on survey data obtained from 1,127 employees of a global company operating in the industrial machinery sector, the authors used structural equation modeling to test the hypothesized model. Findings The results demonstrate that the two aspects of communication visibility yield somew…