Search results for "Inheritance"

On the genetics of the pi serum proteins.

1970

The authors report family studies (51 families with 134 children) on the inheritance of the Pi phenotypes. Combining these data with a Norwegian family material (77 families with 323 children) published by Fagerhol and Gedde-Dahl (1969) a total of 128 families with 457 children is now available, which allows the following conclusion: The Pi phenotypes are inherited by a simple codominant mode of heredity and they are determined by a set of (at least nine) alleles. As up to now no exception to the role of inheritance has been observed, the application of the Pi system in cases of disputed paternity seems to be discussible. Some methodological problems in connection with this are shown.

The time to prevent mendelian genetic diseases from donated or own gametes has come

2015

Morphological studies in canine (Dalmatian) neuronal ceroid-lipofuscinosis.

1988

Dalmatian dogs may develop a neuronal or generalized ceroid-lipofuscinosis (NCL) which strongly resembles that seen in English setters, especially as to the ultrastructural changes and ubiquity of the stored lipopigments and the retinal pathology, while differing clinically from the disorder of English setters in that the disease has a longer course of up to 5 or 6 yr. Clinical onset is at about age 6 months; however, an unequivocal morphological diagnosis is possible between the 4th and 5th month of life in biopsied skin. Detailed data of additional investigations are in progress and are awaiting later publication. Thus, NCL in the Dalmatian dog, though not yet as thoroughly investigated a…

On the genetics of psoriasis

1974

To elucidate the mode of inheritance in psoriasis, Falconer's model for estimating heritability which is under the assumption of multifactorial inheritance, was applied to the data of Hellgren (1967) from Sweden. The heritability estimates were based on both manifest and potential psoriasis since a clear separation of these two categories was impossible. These estimates were 64% for parents, 60% for siblings and 52% for all first degree relatives which included the children of psoriatic cases. For second degree relatives it was 48%. None of these differences are statistically significant. The results are discussed.

The singular fate of Genetics in the History of French Biology, 1900-1940

1988

In this study we have examined the reception of Mendelism in France from 1900 to 1940, and the place of some of the extra-Mendelian traditions of research that contributed to the development of genetics in France after World War II. Our major findings are: (1) Mendelism was widely disseminated in France and thoroughly understood by many French biologists from 1900 on. With the notable exception of Lucien Cuenot, however, there were few fundamental contributions to the Mendelian tradition, and virtually none from about 1915 to the midthirties. Prior to 1900, Cuenot's work was already marked by a striking interest in physiological mechanisms; his physiological preoccupations played a consider…

Identification and prevention of genotyping errors caused by G-quadruplex- and i-motif-like sequences.

2009

Abstract Background: Reliable PCR amplification of DNA fragments is the prerequisite for most genetic assays. We investigated the impact of G-quadruplex– or i-motif–like sequences on the reliability of PCR-based genetic analyses. Methods: We found the sequence context of a common intronic polymorphism in the MEN1 gene (multiple endocrine neoplasia I) to be the cause of systematic genotyping errors by inducing preferential amplification of one allelic variant [allele dropout (ADO)]. Bioinformatic analyses and pyrosequencing-based allele quantification enabled the identification of the underlying DNA structures. Results: We showed that G-quadruplex– or i-motif–like sequences can reproducibly …

Genetic basis of trichome production in Arabidopsis lyrata.

2002

Leaf trichomes may protect plants against herbivorous insects, and may increase tolerance to drought and UV-radiation. The perennial herb Arabidopsis lyrata (Brassicaceae) is polymorphic for trichome production and occurs in a glabrous and trichome-producing form. In addition, there is quantitative variation in trichome density among trichome-producing plants. To examine the genetic basis of glabrousness, we conducted controlled crosses with plants originating from two natural populations in Sweden (one polymorphic for trichome-production, and one consisting of glabrous plants only). In addition, we estimated the heritability of trichome number from parent-offspring regressions for plants o…

El Derecho De La Uniin Europea Ante La Encrucijada Del Impuesto Sobre Sucesiones Y Donaciones Espaaol (EU Law Before the Crossroad of the Spanish Inh…

2014

Spanish Abstract: El articulo analiza los efectos del Derecho de la Union Europea y las libertades fundamentales sobre el impuesto sobre sucesiones y donaciones espanol, teniendo en cuenta las implicaciones y complejas relaciones que derivan de su formulacion como impuesto estatal que ha sido parcialmente cedido a las Comunidades Autonomas. El articulo analiza la posible evolucion tras la sentencia del TJUE de 3 de septiembre de 2014 (asunto C-127/12). El autor critica la argumentacion pobre del TJUE y propone un desarrollo mas consistente del contenido de las libertades fundamentales a partir de un analisis mas solido de los juicios de comparabilidad y de justificacion. El autor tambien cr…

Otto Blüh and Ernst Mach’s Legacy: Inheritance and Task

2019

Otto Bluh (1902–1981) was a professor of physics who maintained a lifelong interest in Mach and contributed actively to previous commemorations. Dozent and first assistant at the German University of Prague, he was forced into exile as a result of the German occupation and held research and academic positions in Birmingham (UK), and the universities of British Columbia (Canada) and Vanderbilt (USA). Bluh not only was a pioneer in recognizing the relevance that physics teaching had in Mach’s ideas but developed many of them, highlighting critical thinking, the importance of history and philosophy in physics, bridging specialization and bringing humanism back to science. This paper provides a…

Characterization of a novel open reading frame, urf a, in the mitochondrial genome of fission yeast: correlation of urf a mutations with a mitochondr…

1991

Between the genes for tRNA(gin) and tRNA(ile) an open reading frame of 227 amino acids has been identified which is unique among known mitochondrial genomes and which has been termed urf a (Lang et al. 1983; Kornrumpf et al. 1984). It uses the "mitochondrial" genetic code, i.e., it contains a TGA codon, whereas all other protein-encoding genes, and all but one intronic open reading frame, use the "standard" genetic code (UGG for tryptophan). A previous paper has demonstrated that "mutator" strains show an increased formation of mitochondrial drug-resistant and respiration-deficient mutants (including deletions). In this paper we show that the mutator activity is correlated with mutations in…