Search results for "Instability"
showing 10 items of 724 documents
Motion and force analysis of slow-speed multi-trailer systems
2018
Comparing with the tractor-trailer systems for the road haulage, which must cope with some typical undesired trends, such as high-speed instability, over- or under-steering and off-tracking, the multi-trailer systems for the transport of luggage in the airports or in the railway stations, or for the transfer of goods in the warehouses, run at quite low speeds, but must manage to steer clear of the many obstacles encountered along their path. This type of vehicle is not subject to tire cornering phenomena, because the speed is just low and the wheels are generally stiff. Hence, the vehicle movement is in practice ruled by the non-holonomic rolling constraint of the wheels and by the steerin…
Smoothed particles hydrodynamics numerical simulations of droplets walking on viscous vibrating liquid
2016
We study the phenomenon of the "walking droplet", by means of numerical fluid dynamics simulations using the Smoothed Particle Hydrodynamics numerical method. This phenomenon occurs when a millimetric drop is released on the surface of an oil of the same composition, contained in a tank and subjected to vertical oscillations of frequency and amplitude very close to the Faraday instability threshold. At appropriate values of the parameters of the system under study, the oil droplet jumps permanently on the surface of the vibrating liquid forming a localized wave-particle system, reminding the behaviour of a wave particle quantum system as suggested by de Broglie. In our study, we made releva…
Strong Instability of Ground States to a Fourth Order Schrödinger Equation
2019
Abstract In this note, we prove the instability by blow-up of the ground state solutions for a class of fourth order Schrödinger equations. This extends the first rigorous results on blowing-up solutions for the biharmonic nonlinear Schrödinger due to Boulenger and Lenzmann [8] and confirm numerical conjectures from [1–3, 11].
Abstract 571: The shared mutation and neoantigen landscape of MMR-deficient colorectal cancers suggests immunoediting during tumor evolution
2019
Abstract The immune system can recognize and attack cancer cells and their precursors, especially those with a high load of mutation-induced neoantigens. Such neoantigens are particularly abundant in DNA mismatch repair (MMR)-deficient cancers. MMR deficiency results in microsatellite instability (MSI), which leads to multiple insertion/deletion mutations at coding microsatellites and to neoantigen-inducing translational frameshifts. The significance of immune selection and immunoediting potentially shaping the neoantigen landscape during the progression from premalignant MMR-deficient lesions into cancers has not yet been analyzed. We hypothesized that the neoantigen landscape of MSI cance…
New chromosome numbers for plant taxa endemic to the Balearic Islands
2006
Mitotic chromosome numbers are reported from 25 vascular plant taxa, endemic to the Balearic Islands that are poorly known cytogenetically. The chromosome numbers ofAnthyllis vulneraria subsp.balearica (2n=12),Cymbalaria fragilis (2n=56), andPolygonum romanum subsp.balearicum (2n=40) were determined for the first time. A new chromosome number was found in several populations ofAnthyllis hystrix (2n=70) suggesting that this species is decaploid, in contrast to an earlier work reporting a higher ploidy level (2n=12x=84). The new chromosome number 2n=32 was reported inHypericum hircinum subsp.cambessedesii. It is suggested that the previous count (2n=40) could be explained by the presence of a…
Interactions between DNA damage, repair, and transcription
2010
This review addresses a variety of mechanisms by which DNA repair interacts with transcription and vice versa. Blocking of transcriptional elongation is the best studied of these mechanisms. Transcription recovery after damage therefore has often been used as a surrogate marker of DNA repair in cells. However, it has become evident that relationships between DNA damage, repair, and transcription are more complex due to various indirect effects of DNA damage on gene transcription. These include inhibition of transcription by DNA repair intermediates as well as regulation of transcription and of the epigenetic status of the genes by DNA repair-related mechanisms. In addition, since transcript…
Brief communication. Stable Drosophila buzzatii-Drosophila koepferae hybrids
1998
Previous experiments discovered high rates of chromosomal rearrangements in the progeny of males containing a telomeric segment of Drosophila koepferae in a D. buzzatii genetic background (segmental males). We have performed similar experiments, designed to test whether this chromosomal instability could be explained by a phenomenon similar to P-M hybrid dysgenesis or, alternatively, by a generalized telomeric effect. However, the results obtained have not allowed us to fully characterize this process, because we have not observed chromosomal rearrangements in the progeny of the putative unstable males. Our results suggest that chromosomal instability is independent of the introgressed frag…
The role of telomeres in predicting individual radiosensitivity of patients with cancer in the era of personalized radiotherapy.
2014
Radiotherapy plays a key role in cancer treatments, but tumor cell death differs from one tumor to another. The response of patients to radiotherapy varies considerably and adverse side effects are difficult to prevent. The mechanisms involved in the heterogeneity of this response are not well understood. In order to enhance the efficacy and safety of radiotherapy, it is important to identify subpopulations most at risk of developing a late adverse response to radiotherapy. Telomeres are composed of multiple repeats of a unique sequence of nucleotides forming a TTAGGG pattern. They protect chromosomes from end-to-end fusion and maintain genomic stability. Telomeres have been shown to be ext…
Fanconi anemia (FA) and crosslinker sensitivity: Re-appraising the origins of FA definition
2015
The commonly accepted definition of Fanconi anemia (FA) relying on DNA repair deficiency is submitted to a critical review starting from the early reports pointing to mitomycin C bioactivation and to the toxicity mechanisms of diepoxybutane and a group of nitrogen mustards causing DNA crosslinks in FA cells. A critical analysis of the literature prompts revisiting the FA phenotype and crosslinker sensitivity in terms of an oxidative stress (OS) background, redox-related anomalies of FA (FANC) proteins, and mitochondrial dysfunction. This re-appraisal of FA basic defect might lead to innovative approaches both in elucidating FA phenotypes and in clinical management.
DNA Photodamage and Repair: Computational Photobiology in Action
2020
DNA is constantly exposed to external and metabolic stress agents, including the solar radiation and in particular the UV portion of the electromagnetic spectrum. Such source of stress can induce photochemical modification of the structure of DNA and of its basic components, i.e. the nucleobases. DNA lesions may ultimately lead to genomic instability, mutations, and even to carcinogenesis. Hence, cells dispose of complex biochemical repair pathways in charge of remove the DNA lesions and avoid their accumulation. In this Chapter, we present the complexity of the DNA lesion chemical and structural space, also complicated by the intricate coupling with the biological relevant signaling pathwa…