Search results for "Instability"
showing 10 items of 724 documents
Active tectonics, sedimentation history and geomorphological features in the northern Sicily continental margin: implications for the marine geohazar…
2020
Starting from the assumption that seismic events in the active margins are accompanied by evidence of a depositional, geomorphologic and structural type, which constitutes the geological record of their activity, we analysed different features of the Northern Sicily continental margin (NSCM) to reconstruct the deformational field and related stress field in the Southern Tyrrhenian sea. As an outcome of this project we were going to obtain seismotectonic setting and mapping to provide a powerful tool in managing and assessing the marine geological hazards. The study area extends from the San Vito Peninsula to the Termini Gulf along the NSCM, including the Ustica island, and is located in a t…
RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation
2009
BACKGROUND: Changes in chromosome number or structure as well as supernumerary centrosomes and multipolar mitoses are commonly observed in human tumors. Thus, centrosome amplification and mitotic checkpoint dysfunctions are believed possible causes of chromosomal instability. The Retinoblastoma tumor suppressor (RB) participates in the regulation of synchrony between DNA synthesis and centrosome duplication and it is involved in transcription regulation of some mitotic genes. Primary human fibroblasts were transfected transiently with short interfering RNA (siRNA) specific for human pRb to investigate the effects of pRb acute loss on chromosomal stability. RESULTS: Acutely pRb-depleted fibr…
At‐risk children's causal inferences given emotional feedback and their understanding of the excuse‐giving process
1994
Italian male school children, ranging in age from 7 to 10 years, were identified as at‐risk children on the basis of self‐reports, teacher questionnaires, and peer nominations assessing aggression, emotional instability, and pro‐social behaviour. Together with a normal control sample, these children participated in two studies guided by attribtional theory. In Study 1, following teacher emotional feedback of anger or sympathy for failure, attributional inferences regarding low ability or lack of effort as the cause of that failure were rated. In Study 2, controllable and uncontrollable causes of a social transgression were given, and participants rated the anticipated anger of the ‘victim’…
The tumor-agnostic treatment for patients with solid tumors: a position paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIF Italian Scientific Societi…
2021
The personalized medicine is in a rapidly evolving scenario. The identification of actionable mutations is revolutionizing the therapeutic landscape of tumors. The morphological and histological tumor features are enriched by the extensive genomic profiling, and the first tumor-agnostic drugs have been approved regardless of tumor histology, guided by predictive and druggable genetic alterations. This new paradigm of "mutational oncology", presents a great potential to change the oncologic therapeutic scenario, but also some critical aspects need to be underlined. A process governance is mandatory to ensure the genomic testing accuracy and homogeneity, the economic sustainability, and the r…
WAVES PROPAGATION AND LIQUID ALUMINUM PARTICLE INJECTION IN SOLID ROCKET MOTORS
2013
A method to determine the injection of aluminium particles from the solid propellant burning surface to the core of the chamber in the presence of an acoustic wave field is developed and aluminum-droplet effects on propagation of acoustic waves in the flow of a solid rocket motor are analysed. Changes of the multiphase flow compressibility are calculated by taking into account both the translational and the pulsational motions of the aluminum droplets in consequence of the acoustic waves.
Numerical study of blow-up and stability of line solitons for the Novikov-Veselov equation
2017
International audience; We study numerically the evolution of perturbed Korteweg-de Vries solitons and of well localized initial data by the Novikov-Veselov (NV) equation at different levels of the 'energy' parameter E. We show that as |E| -> infinity, NV behaves, as expected, similarly to its formal limit, the Kadomtsev-Petviashvili equation. However at intermediate regimes, i.e. when |E| is not very large, more varied scenarios are possible, in particular, blow-ups are observed. The mechanism of the blow-up is studied.
Self-assembly of a bioelastomeric structure: solution dynamics and the spinodal and coacervation lines.
1990
The stability, metastability, and instability regions of aqueous solutions of a representative synthetic bioelastomeric polymer, poly (Val-Pro-Gly-Val-Gly), were determined by a combined use of elastic and quasi-elastic light scattering experiments. The approach followed here offers the attractive advantage of singling out the relevant contributions to the total scattering even in the presence of traces of noninteracting larger sized impurities. Conclusions so reached were checked by means of independent experiments. The present results provide descriptions of the very early events in the physics of bioelastogenesis in terms of general polymer science and phase transitions, and in terms of …
Protein aggregation/crystallization and minor structural changes: universal versus specific aspects.
2007
AbstractProtein association covers wide interests in biophysics, protein science, and biotechnologies, and it is often viewed as governed by conformation details. More recently, the existence of a universal physical principle governing aggregation/crystallization processes has been suggested by a series of experiments and shown to be linked to the universal scaling properties of concentration fluctuations occurring in the proximity of a phase transition (spinodal demixing in the specific case). Such properties have provided a quantitative basis for capturing kinetic association data on a universal master curve, ruled by the normalized distance of the state of the system from its instability…
Active monetary policy and instability in a phillips curve system
1998
The presence of nonlinearities in a Phillips curve system yields to complex dynamics, i.e., cyclical behavior that may (under some parametric set) become chaotic. This paper extends these conclusions by including an active monetary policy. We show how stabilization policy may lead to amplified instabilities and that agents' expectations tend to play a key role in the amount of these instabilities.
Cross-diffusion-induced subharmonic spatial resonances in a predator-prey system.
2018
In this paper we investigate the complex dynamics originated by a cross-diffusion-induced subharmonic destabilization of the fundamental subcritical Turing mode in a predator-prey reaction-diffusion system. The model we consider consists of a two-species Lotka-Volterra system with linear diffusion and a nonlinear cross-diffusion term in the predator equation. The taxis term in the search strategy of the predator is responsible for the onset of complex dynamics. In fact, our model does not exhibit any Hopf or wave instability, and on the basis of the linear analysis one should only expect stationary patterns; nevertheless, the presence of the nonlinear cross-diffusion term is able to induce …