Search results for "Integument"
showing 10 items of 754 documents
Abstract 1605: Pterostilbene, a natural phytoalexin, effectively protects against UVB-induced skin carcinogenesis by increasing antioxidant cellular …
2014
Abstract Clinical and laboratory studies have demonstrated that skin exposure to ultraviolet radiation (UV) is the main cause of non-melanoma skin cancer (NMSC) (≈ 99%) and melanoma (≈ 95%) development. The procarcinogenic effects of solar exposure are mainly due to UVB radiation (290-320 nm range), the same tight range that produces burning in human skin (erythema), inflammation, oxidative stress, DNA damage, etc. The number of skin cancers around the world keeps increasing and, thus, it is an urgent need to find effective protection remedies. Phytoalexins of polyphenolic structure are naturally occurring compounds involved in the defense against pathogens and environmental stresses in pla…
Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues
1988
Abstract Cells forming hair and nail material are characterized by the synthesis of members of a particular group of α-keratin polypeptides (trichocytic cytokeratins, “T cytokeratins”) different from epithelial cytokeratins (“E cytokeratins”). As the precursor cells to trichocytes are derived from fetal epidermal keratinocytes expressing only E cytokeratins, we have studied the patterns of expression of both T and E cytokeratins in developing human hair-and nailforming tissues of different fetal stages, by immunocyto-chemistry using antibodies specific for certain T or E cytokeratins and by two-dimensional gel electrophoresis and immunoblotting. In developing hair follicles up to the early …
In vivo imaging and quantification of the continuous keratin filament network turnover
2008
Keratin polypeptides are major components of the epithelial cytoskeleton forming a filamentous 3D-network. Like intermediate filament polypeptides of other cell types, keratins make up a stable, but elastic network that is responsible for mechanical stress resilience. At the same time the keratin network is able to change its shape during development, cell division, metastasis and cell migration.
γ-Oryzanol and tocopherol contents in residues of rice bran oil refining
2012
Rice bran oil (RBO) contains significant amounts of the natural antioxidants γ-oryzanol and tocopherols, which are lost to a large degree during oil refining. This results in a number of industrial residues with high contents of these phytochemicals. With the aim of supporting the development of profitable industrial procedures for γ-oryzanol and tocopherol recovery, the contents of these phytochemicals in all the residues produced during RBO refining were evaluated. The samples included residues from the degumming, soap precipitation, bleaching earth filtering, dewaxing and deodorisation distillation steps. The highest phytochemical concentrations were found in the precipitated soap for γ-…
A novel and ancient group of type I keratins with members in bichir, sturgeon and gar
2006
Abstract 1. Background Vertebrate epithelial cells typically express a specific set of keratins. In teleosts, keratins are also present in a variety of mesenchymal cells, which usually express vimentin. Significantly, our previous studies revealed that virtually all known teleost keratins evolved independently from those present in terrestrial vertebrates. To further elucidate the evolutionary scenario that led to the large variety of keratins and their complex expression patterns in present day teleosts, we have investigated their presence in bichir, sturgeon and gar. 2. Results We have discovered a novel group of type I keratins with members in all three of these ancient ray-finned fish, …
Identification of Novel Principles of Keratin Filament Network Turnover in Living Cells
2004
It is generally assumed that turnover of the keratin filament system occurs by exchange of subunits along its entire length throughout the cytoplasm. We now present evidence that a circumscribed submembranous compartment is actually the main site for network replenishment. This conclusion is based on the following observations in living cells synthesizing fluorescent keratin polypeptides: 1) Small keratin granules originate in close proximity to the plasma membrane and move toward the cell center in a continuous motion while elongating into flexible rod-like fragments that fuse with each other and integrate into the peripheral KF network. 2) Recurrence of fluorescence after photobleaching i…
Contribution to the Knowledge of Dermatophytic Invasion of Hair
1970
We have used the scanning electron microscope to investigate the changes that occur in scalp hair during infection with Trichophyton violaceum . We provide information on the morphology of these dermatophytes and present evidence that their hyphae dig tunnel-like burrows into the hair shaft, dissociating hair into keratin fibrils.
Feature characterization of scarring and non-scarring types of alopecia by multiphoton microscopy (Conference Presentation)
2018
Treatment and management of alopecia are highly determined by an accurate diagnosis, which can be challenging due to the lack of methods to properly visualize hair follicles. Current standard diagnosis is based on dermoscopy for non-scarring alopecia and scalp biopsy for scarring types of alopecia. Dermoscopy can be inconclusive, while biopsy is a painful procedure. In this study, we used a clinical tomograph based on multiphoton microscopy (MPM) to non-invasively image the scalp of 5 healthy subjects and of 12 patients affected by non-scarring alopecia (androgenetic and areata) and scarring alopecia (frontal fibrosing). MPM is capable of non-invasive in vivo imaging of follicular structure…
Enhanced Skin Permeation of Estradiol by Dimethyl Sulfoxide Containing Transdermal Patches.
2021
Dimethyl sulfoxide is a well-known and widely used dermal penetration enhancer. Its incorporation in transdermal patches would be highly desirable
Interaction of Dimethyltin(IV)2+ Cation with Gly-Gly, Gly-His, and Some Related Ligands. A New Case of a Metal Ion Able To Promote Peptide Nitrogen D…
1999
Equilibrium (pH-metric) and spectroscopic (1H,13C, and 119Sn NMR and 119Sn Mossbauer) studies were performed to characterize the interaction of the dimethyltin(IV) cation with glycine, glycyl-glycine (Gly-Gly), imidazole-4-acetic acid, histamine, histidine, glycyl-histamine, glycyl-histidine (Gly-His), and β-alanyl-histidine (carnosine). For histamine and glycyl-histamine (having only nitrogen donor atoms) no complex formation was detected. The hydrolyzed species of the dimethyltin(IV) cation are always dominant over the complexes formed with the other ligands, except with Gly-Gly and Gly-His. For these two ligands, {COO-,N-,NH2} coordinated complexes are dominant in the neutral pH range wi…