Search results for "Intellect"

Human Resource Management Models: Aspects of Knowledge Management and Corporate Social Responsibility

2014

AbstractOver time, changes have affected not only the attitude towards people employed in organizations and the knowledge and intellectual capital, but also social values and responsibility. The aim of the paper is to analyse and assess the aspects of knowledge management and corporate social responsibility and their development in different human resource management (HRM) models. While researching the issue of HRM impact on the organizational performance, the authors have analysed several HRM models that show the relationship between HRM practices, the factors influencing their choice, and the organizational outcomes. The models differ with the unitary approach, which believes that employe…

Orientālistika (Latvijas Universitātes Raksti, 803. sēj.)

2015

New Insights into Potocki-Shaffer Syndrome: Report of Two Novel Cases and Literature Review

2020

Potocki-Shaffer syndrome (PSS) is a rare non-recurrent contiguous gene deletion syndrome involving chromosome 11p11.2. Current literature implies a minimal region with haploinsufficiency of three genes, ALX4 (parietal foramina), EXT2 (multiple exostoses), and PHF21A (craniofacial anomalies, and intellectual disability). The rest of the PSS phenotype is still not associated with a specific gene. We report a systematic review of the literature and included two novel cases. Because deletions are highly variable in size, we defined three groups of patients considering the PSS-genes involved. We found 23 full PSS cases (ALX4, EXT2, and PHF21A), 14 cases with EXT2-ALX4, and three with PHF21A only…

De novo GRIN2A variants associated with epilepsy and autism and literature review

2021

N-methyl-D-aspartate receptors (NMDAR) are di- or tri-heterotetrameric ligand-gated ion channels composed of two obligate glycine-binding GluN1 subunits and two glutamate-binding GluN2 or GluN3 subunits, encoded by GRIN1, GRIN2A–D, and GRIN3A–B receptor genes respectively. Each NMDA receptor subtype has different temporal and spatial expression patterns in the brain and varies in the cell types and subcellular localization resulting in different functions. They play a crucial role in mediating the excitatory neurotransmission, but are also involved in neuronal development and synaptic plasticity, essential for learning, memory, and high cognitive functions. Among genes coding NMDAR subunits…

Les commanditaires d'oeuvres d'art en Bourgogne (1360-1420)

2004

International audience

La musique dans le Banquet du Faisan d'après Olivier de la Marche

2003

dir. Jean-Marie Cauchies; International audience

Edwin A. Judge: The First Christians in the Roman World. Augustan and New Testament Essays

2009

The Intellectual Capital and its Management in the Local Public Utility

2011

Purpose- To highlight the importance of intellectual capital in ISPL and also as a proper management can improve business performance.

Antyfilozofia cynicka w Nigrinosie Lukiana

2013

Cynics in their pursuit of “defacing the coinage” did not content themselves with critique of culture from philosophical point of view, but turned warrant given by Apollon against philosophy itself. Th e root of cynical anti-philosophy was antiintelectualism and antiplatonism of Anthisthenes and his early followers. Lucian’s Nigrinos is a fine example of late cynical anti-philosophy. Author unfolds before reader panorama of 2nd century Athens, where philosophy is a widely accepted form of life and the object of communal education. Both satirical description of the city of philosophers and the quasi-religious conversion of the main speaker provide a comprehensive view of philosophy as an irr…

Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans

2017

International audience; Gain-of-function mutations in some genes underlie neurodegenerative conditions, whereas loss-of-function mutations in the same genes have distinct phenotypes. This appears to be the case with the protein ataxin 1 (ATXN1), which forms a transcriptional repressor complex with capicua (CIC). Gain of function of the complex leads to neurodegeneration, but ATXN1-CIC is also essential for survival. We set out to understand the functions of the ATXN1-CIC complex in the developing forebrain and found that losing this complex results in hyperactivity, impaired learning and memory, and abnormal maturation and maintenance of upper-layer cortical neurons. We also found that CIC …