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RESEARCH PRODUCT
Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans
Richard H. FinnellDella E. BroMaria E. Zurita-jimenezYoontae LeeYoontae LeeHsiang Chih LuHsiang Chih LuPriyanka AhimazXiuyun LiuHarry T. OrrYing Wooi WanM. Cecilia LjungbergChristian P. SchaafWei WangJi-yoen KimNora AlexanderMaxime W.c. RousseauxJing HanJing HanRoy V. SillitoeJohn D. FryerJohn D. FryerRonald RichmanSzu Ying YehQiumin TanKwame Anyane-yeboaLionel Van MaldergemHuda Y. ZoghbiJulien ThevenonZhandong LiuNolwenn Jean-marçaisDaphné LehalleBrendan C. LanpherEric W. KleeMaria H. ChahrourMaria H. ChahrourAnne Laure Mosca-boidronYunping LeiJay M. PatelMargot A. CousinTao LinMatthew N. Bainbridgesubject
Male0301 basic medicineAutism Spectrum DisorderAtaxin 1neuronsautismNerve Tissue Proteinsattention-deficit/hyperactivity disorderAmygdalaArticleMice03 medical and health sciencesTranscriptional repressor complexataxin-1Cerebellum[ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathologyGeneticsmedicineAnimalsHumansAttention deficit hyperactivity disorderInterpersonal Relationssca1 neuropathologybiologysocial-behaviorNeurodegenerationcag repeatNuclear ProteinsNeurodegenerative Diseasesmedicine.diseasePhenotypeRepressor ProteinsPhenotype030104 developmental biologymedicine.anatomical_structureAutism spectrum disorderintellectual disabilitybiology.proteinAutismFemaleNeurosciencetime pcr datarepressor capicua[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologydescription
International audience; Gain-of-function mutations in some genes underlie neurodegenerative conditions, whereas loss-of-function mutations in the same genes have distinct phenotypes. This appears to be the case with the protein ataxin 1 (ATXN1), which forms a transcriptional repressor complex with capicua (CIC). Gain of function of the complex leads to neurodegeneration, but ATXN1-CIC is also essential for survival. We set out to understand the functions of the ATXN1-CIC complex in the developing forebrain and found that losing this complex results in hyperactivity, impaired learning and memory, and abnormal maturation and maintenance of upper-layer cortical neurons. We also found that CIC activity in the hypothalamus and medial amygdala modulates social interactions. Informed by these neurobehavioral features in mouse mutants, we identified five individuals with de novo heterozygous truncating mutations in CIC who share similar clinical features, including intellectual disability, attention deficit/hyperactivity disorder (ADHD), and autism spectrum disorder. Our study demonstrates that loss of ATXN1-CIC complexes causes a spectrum of neurobehavioral phenotypes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-04-01 |