Search results for "Interim"
showing 10 items of 95 documents
IOC consensus statement on relative energy deficiency in sport (RED-S): 2018 update
2018
In 2014, the IOC published a consensus statement entitled ‘Beyond the Female Athlete Triad: Relative Energy Deficiency in Sport (RED-S)’. The syndrome of RED-S refers to ‘impaired physiological functioning caused by relative energy deficiency and includes, but is not limited to, impairments of metabolic rate, menstrual function, bone health, immunity, protein synthesis and cardiovascular health’. The aetiological factor of this syndrome is low energy availability (LEA).1 The publication of the RED-S consensus statement stimulated activity in the field of Female Athlete Triad science, including some initial controversy2 3 followed by numerous scientific publications addressing: 1. The health…
Outcome Prediction in Node-Negative Breast Cancer Based on ASCO-Recommended Biomarkers uPA/PAI-1 Using the Final 10-Year Analysis of the Randomized M…
2009
Abstract Background: Based on interim analysis of Chemo N0, the first prospective multicenter randomized clinical trial using biomarkers uPA/PAI-1 for risk stratification and chemotherapy selection in N0 breast cancer, uPA/PAI-1 are now recommended for routine use by ASCO and AGO guidelines. Final 10-year follow-up of Chemo N0 has validated the clinically relevant long-term prognostic and predictive impact of uPA/PAI-1 in N0 breast cancer. To quantify the clinical utility of this impact, outcomes in subgroups defined by these biomarkers were compared to predictions of Adjuvant Online™, the leading validated tool based on established clinical factors. Methods: In Chemo N0, patients (n=647, 1…
Add-on Peginterferon Alfa-2a significantly reduces HBsAg levels in chronic hepatitis B, HBeAg-negative, genotype D patients fully suppressed on nucle…
2015
Health-Related Quality of Life in Italian Patients With Moderate and Severe Crohn's Disease: Interim Results from the Sole Study
2014
Escuelas para niños y escuelas para niñas en el Trienio liberal
2020
During the Liberal Triennium, the first law of public instruction is approved in Spain, and the project of general regulations of primary schools is rehearsed on an interim basis. The education is directed to boys, as future citizens, must strengthen the liberal system while girls must attend home and family. The reform failed due to the shortage of public funds, and the short time the law was in force. After that attempt, this legal initiative would not be considered again with the consolidated constitutional system, unlike other projects of the triennium.Fecha de envio / Submission date: 12/02/2020Fecha de aceptacion / Acceptance date: 10/04/2020
Depth of response to isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa-KRd) in front-line treatment of high-risk multiple myeloma: Interi…
2020
8508 Background: High-risk (HR) multiple myeloma (MM) still has a significant impaired prognostic outcome. Addition of CD38 monoclonal antibodies to standard-of-care regimens significantly improved response rates and depth of response in newly diagnosed (ND) and relapsed/refractory MM patients (pts). Here, we report the prespecified end of induction interim analysis (IA) of the investigator-initiated GMMG-CONCEPT trial (NCT03104842), evaluating the quadruplet regimen isatuximab plus carfilzomib, lenalidomide and dexamethasone (Isa-KRd) in HR NDMM pts. Methods: 153 pts with HR NDMM are planned to be included into the trial. HR MM is defined by the presence of del17p or t(4;14) or t(14;16) o…
Description of the Interim Peculiarities of Mental Developmental and Learning Disturbances
2015
More and more pupils with special needs, including those with learning disturbances and simple mental developmental disturbances, are attending general comprehensive educational institution. It is often difficult in practice to define clearly and differentiate these two kinds of disturbances, especially in borderline cases or in the interim stage because then the features and manifestations of learning disturbances and simple mental developmental disturbances partly overlap and change. The novelty of the article is the analysis of the interim peculiarities and manifestations of these two disturbances which will allow teachers to understand better the main learning difficulties of such pupil…
The impact of Finno-Ugric languages in second language research: Looking back and setting goals
2012
This state of the art review aims at discussing the potential relevance of Finno-Ugric languages in the larger context of second language research. Key results received in the studies conducted in the field of Finno-Ugric languages as second languages are introduced, and some interim conclusions based on them are made. The main areas in focus are cross-linguistic influence, forms and constructions, second language interaction, and motivation, identities and integration. Furthermore, some future lines of investigation are suggested for the researchers of the field. The research activities are recommended to get more closely bound to the internationally established or emerging paradigms, and …
Design, implementation, and evaluation of the adolescents and surveillance system for the obesity prevention project
2016
Abstract The Adolescents Surveillance System for Obesity prevention (ASSO) Project aimed at developing standardized and web-based tools for collecting data on adolescents’ obesity and its potential determinants. This has been implemented and piloted in the local area of Palermo city, Italy. The aim of the present study is to provide an overview of the Project's design, implementation, and evaluation, highlighting all the aspects for a potential scale-up of the surveillance system on the whole national territory and abroad, as a sustainable and effective source of data. The overall structure and management, the ASSO-toolkit, the ASSO-NutFit software, and all developed and used procedures for…
Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 tria…
2019
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