6533b829fe1ef96bd128afe7

RESEARCH PRODUCT

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial.

Zobair M YounossiVlad RatziuRohit LoombaMary RinellaQuentin M. AnsteeZachary GoodmanPierre BedossaAndreas GeierSusanne BeckebaumPhilip N NewsomeDavid SheridanMuhammad Y SheikhJames TrotterWhitfield KnappleEric LawitzManal F AbdelmalekKris V KowdleyAldo J Montano-lozaJerome BoursierPhilippe MathurinElisabetta BugianesiGiuseppe MazzellaAntonio OlveiraHelena Cortez-pintoIsabel GrauperaDavid OrrLise Lotte GluudJean-francois DufourDavid ShapiroJason CampagnaLuna ZaruLeigh MacconellReshma ShringarpureStephen HarrisonArun J SanyalManal AbdelmalekGary AbramsHumberto AguilarAijaz AhmedElmar AignerGuruprasad P AithalAftab AlaWilliam AlazawiAgustin AlbillosMichael AllisonSfa Al-shammaRaul AndradePietro AndreoneMario AngelicoVictor Ankoma-seyQuentin AnsteeRodolphe AntyVictor ArayaJuan Ignacio Arenas RuizPerttu ArkkilaMarty AroraTarik AsselahJennifer AuOyekoya AyonrindeRobert James BaileyMaya BalakrishnanKiran BambhaMeena BansalSidney BarrittJohn BateJorge BeatoSusanne BeckebaumJaideep BehariPablo BellotZiv Ben AriMichael BennettMarina BerenguerBenedetta Terziroli Beretta-piccoliThomas BergMaurizio BonaciniLucia BonetBrian BorgMarc BourliereJerome BoursierWilliam BowmanDavid BradleyMarija BrankovicMarius BraunJean-pierre BronowickiSavino BrunoElisabetta BugianesiCindy CaiAmy CalderonJosé Luis Calleja PaneroElizabeth CareyMichal CarmielJose Antonio CarriónMatthew CaveCristina ChagasTawfik ChamiAlan ChangAllan CoatesJeremy CobboldCharlote CostentinKathleen CoreyLynsey CorlessHelena Cortez-pintoJavier CrespoOscar Cruz PereiraVictor De LedinghenAndrew DelemosMoises DiagoMamie DongJean-françois DufourPredrag DugalicWinston DunnMagby ElkhashabMichael EpsteinMaria Desamparados Escudero-garciaOhad EtzionLarry EvansRobert FalconeConrado FernandezJose FerreiraScott FinkKevin FinneganRoberto Firpi-morellAnnarosa FloreaniThierry FontangesRyan FordEwan ForrestAndrew FowellAnna Ludovica FracanzaniSven FrancqueBradley FreilichJuan FriasMichael FuchsJavier FuentesMichael GalambosJuan GallegosAnja GeertsAndreas GeierJacob GeorgeMaged GhaliReem GhalibPierre GholamPere GinesNorman GitlinLise Lotte GluudTobias GoeserJohn GoffStuart GordonFrederic GordonOdile GoriaShaun GreerAlla GrigorianHenning GronbaekMaeva GuillaumeNaresh GunaratnamDina Halegoua-de MarzioBilal HameedStephanie HametnerJames HamiltonStephen HarrisonMarek HartlebTarek HassaneinDieter HäussingerPaul HellsternRobert HerringEva HeurichChristophe HezodeHolger HinrichsenPeter Holland FischerYves HorsmansJonathan HuangHyder HussainiAntoine JakicheLennox JeffersBlake JonesRosa JorgeFrancisco JorqueraShoba JoshiAlisan KahramanKelly KaitaNicholas KaryotakisZeid KayaliStergios KechagiasThomas KepczykMandana KhaliliHicham KhallafiJohannes KluweWhitfield KnappleAnita KohliKevin KorenblatKris KowdleyAleksander KragRichard KrauseAndreas KremerKaren KrokMiodrag KrsticMarcelo KugelmasSonal KumarScott KuwadaDamien LabarriereMichelle LaiWim LalemanPietro LamperticoEric LawitzAlice LeeVincent LeroySteven LidofskyTina Huey LimJoseph LimDonald LipkisEster LittleAmadeo LonardoMichelle LongRohit LoombaVelimir Anthony Christopher LuketicYoav LurieGuilherme MacedoJoana MagalhaesMihály MakaraBenedict MaliakkalMichael MannsPinelopi ManousouParvez MantryGiulio MarchesiniCarla MarinhoPaul MarottaHanns-ulrich MarschallLinda MartinezPhilippe MathurinMarlyn MayoGiuseppe MazzellaMark MccullenWilliam MclaughlinUta MerleRaphael MerrimanApurva ModiEsther MolinaAldo Montano-lozaCarlos MonteverdeAmilcar Morales CardonaSulleman MoreeaChristophe MorenoFilomena MoriscoAbdullah MubarakBeat MuellhauptSandeep MukherjeeTobias MüllerAleksandar NagorniJahnavi NaikGuy NeffMoises NevahPhilip N. NewsomeEric Nguyen-khacMazen NoureddinJude ObenAntonio OlveiraHans OrlentDavid OrrJames OrrGrisell Ortiz-lasantaViolaine OzennePrashant PandyaAngelo ParedesJames ParkJoykumar PatelKeyur PatelSonali PaulHeather PattonMarkus Peck-radosavljevicSalvatore PettaStephen PiankoAnna PiekarskaNeville PimstoneJoseph PisegnaPaul PockrosStanislas PolMichael PoraykoJohn PoulosDavid PoundJoe PouzarJose Presa RamosNikolaos PyrsopoulosNila RafiqKate MullerAlnoor RamjiVlad RatziuRavi RavinuthalaChakradhar ReddyGautham Reddy K GK. Rajender Reddy K RFrederic RegensteinRobert ReindollarJustin ReynoldsAndres RieraMary RinellaJose Rivera AcostaGeert RobaeysStuart RobertsFederico Rodriguez-perezSandor RomeroManuel Romero‐gomezRaymond RubinMariagrazia RumiSimon RushbrookChristian RustMichael RyanRifaat SafadiAdnan SaidKimmo SalminenDidier SamuelJohn SantoroArun SanyalSouvik SarkarCynthia SchaefferJörn SchattenbergIngolf SchiefkeEugene SchiffWolfgang SchmidtJeffrey SchneiderJeoffrey SchoutenMichael SchultzGiada SebastianiDavid SemelaThomas SepeAasim SheikhMuhammad SheikhDavid SheridanKenneth ShermanOren ShiboletMitchell ShiffmanAsma SiddiqueCyril SieberhagenSamuel SigalKatarzyna SikorskaKrzysztof SimonMarie SinclairRichard SkoienJoel SolisSiddharth SoodBob SouderJames SpiveyPer StalLaura StintonSimone StrasserPetar SvorcanGyongzi SzaboAndrew TalalEdward TamBrent TetriPaul ThuluvathHillel TobiasKrzysztof TomasiewiczDawn TorresAlbert TranMichael TraunerChristian TrautweinJames TrotterEmmanuel TsochatzisEsther UnittVictor VargasIstvan VarkonyiElla VeitsmanUmberto Vespasiani GentilucciDavid VictorJohn VierlingCatherine VincentAron VinczeManfred Von Der OheNatasha Von RoennRaj VuppalanchiMichael WatersKymberly WattJulia WattacherilMartin WeltmanAmanda WielandGregory WienerAlonzo Williams AJeffrey Williams JJason WilsonMaria YatacoEric YoshidaZiad YounesLiyun YuanAdam ZivonyDonald ZoggHeinz ZollerFabien ZoulimEli ZuckermanMassimo Zuin

subject

MaleBiopsyClinical Trial Phase IIIAdministration Oral030204 cardiovascular system & hematologyChronic liver diseaseSettore MED/04Biomarkers/analysisGastroenterologychemistry.chemical_compound0302 clinical medicine/dk/atira/pure/researchoutput/pubmedpublicationtype/D013485Liver Function TestsNon-alcoholic Fatty Liver DiseaseClinical endpointMedicine030212 general & internal medicine610 Medicine & healthChenodeoxycholic Acid/administration & dosageeducation.field_of_studyLiver Function TestResearch Support Non-U.S. Gov'tFatty liverObeticholic acidNASH OBETICHOLIC ACIDGeneral Medicine/dk/atira/pure/researchoutput/pubmedpublicationtype/D052061Middle AgedMulticenter Study/dk/atira/pure/researchoutput/pubmedpublicationtype/D016448Randomized Controlled TrialAdministrationFemale/dk/atira/pure/researchoutput/pubmedpublicationtype/D016449Administration Oral; Biomarkers; Biopsy; Chenodeoxycholic Acid; Double-Blind Method; Female; Humans; Liver Function Tests; Male; Middle Aged; Non-alcoholic Fatty Liver DiseaseHumanOralmedicine.medical_specialtyPopulationPlaceboChenodeoxycholic Acid03 medical and health sciencesResearch Support N.I.H. ExtramuralDouble-Blind MethodInternal medicineJournal ArticleHumans/dk/atira/pure/researchoutput/pubmedpublicationtype/D017428educationIntention-to-treat analysisbusiness.industryBiomarkerInterim analysismedicine.diseaseNon-alcoholic Fatty Liver Disease/drug therapychemistryHuman medicine/dk/atira/pure/researchoutput/pubmedpublicationtype/D016428businessBiomarkersAdministration; Oral; Biomarkers; Biopsy; Chenodeoxycholic Acid; Double-Blind Method; Female; Humans; Liver Function Tests; Male; Middle Aged; Non-alcoholic Fatty Liver Disease

description

© 2019 Elsevier Ltd. All rights reserved.

yearjournalcountryeditionlanguage
2019-12-01
https://dx.doi.org/10.7892/boris.137067