Search results for "Intravenou"

showing 10 items of 390 documents

Invited Commentary: From Moral Reflexes to Ethical Reflection: Ethical Commentary on the Refusal of Cardiac Surgery in Patients with Intravenous Drug…

2015

Pulmonary and Respiratory Medicinemedicine.medical_specialtyIntravenous drugbusiness.industry06 humanities and the arts0603 philosophy ethics and religionmedicine.diseaseCardiac surgeryAcquired immunodeficiency syndrome (AIDS)medicineSurgeryIn patient060301 applied ethicsCardiology and Cardiovascular MedicineIntensive care medicineReflection (computer graphics)businessActive hepatitisThe Thoracic and Cardiovascular Surgeon
researchProduct

Demographic and clinical data in acquired hemophilia A

2012

Summary.  Background:  Acquired hemophilia A (AHA) is a rare autoimmune disease caused by autoantibodies against coagulation factor VIII and characterized by spontaneous hemorrhage in patients with no previous family or personal history of bleeding. Although data on several AHA cohorts have been collected, limited information is available on the optimal management of AHA. Objectives:  The European Acquired Hemophilia Registry (EACH2) was established to generate a prospective, large-scale, pan-European database on demographics, diagnosis, underlying disorders, bleeding characteristics, treatment and outcome of AHA patients. Results:  Five hundred and one (266 male, 235 female) patients from …

RegistrieMalePediatricsdiagnosismedicine.medical_treatmentHemostatic TechniqueKaplan-Meier EstimateregistryTHERAPYSettore MED/15 - Malattie Del SangueImmunosuppressive AgentIMMUNOADSORPTIONRisk FactorsPregnancy80 and overProspective StudiesRegistriesProspective cohort studyhealth care economics and organizationsAged 80 and overtreatmentImmunosuppressionHematologyMiddle AgedFACTOR-VIII INHIBITORAcquired hemophilia; Demographics; Diagnosis; Outcome; Registry; Treatment; Aged; Aged 80 and over; Autoantibodies; Chi-Square Distribution; Europe; Factor VIII; Female; Hemostatic Techniques; Humans; Immunosuppressive Agents; Kaplan-Meier Estimate; Male; Middle Aged; Pregnancy; Prospective Studies; Registries; Risk Assessment; Risk Factors; Treatment Outcome; Hemophilia A; HemorrhageAutoantibodieEuropeTreatment Outcomeacquired hemophilia; demographics; diagnosis; outcome; registry; treatmentoutcomeINTRAVENOUS GAMMA-GLOBULINFemaleacquired hemophiliaImmunosuppressive AgentsHumanmedicine.medical_specialtyHemorrhageHemophilia AMalignancyRisk Assessmenthemophilia registrydemographicsmedicineHumansMETAANALYSISAutoantibodiesAgedAutoimmune diseasePregnancyChi-Square DistributionFactor VIIIHemostatic Techniquesbusiness.industryRisk FactorAutoantibodymedicine.diseaseSurgeryProspective StudieHemostasisbusinessChi-squared distributionJournal of Thrombosis and Haemostasis
researchProduct

IqYmune® is an effective maintenance treatment for multifocal motor neuropathy: A randomised, double‐blind, multi‐center cross‐over non‐inferiority s…

2018

Intravenous immunoglobulin (IVIg) is the gold-standard for maintenance treatment of multifocal motor neuropathy (MMN). This phase III, randomised, double-blind, multi-centre, active-control, crossover study, aimed to evaluate the non-inferiority of IqYmune® relative to Kiovig®, primarily based on efficacy criteria. Twenty-two adult MMN patients, treated with any brand of IVIg (except Kiovig® or IqYmune®) at a stable maintenance dose within the range of 1 to 2 g/kg every 4 to 8 weeks, were randomised to receive either Kiovig® followed by IqYmune®, or IqYmune® followed by Kiovig®. Each product was administered for 24 weeks. The primary endpoint was the difference between IqYmune® and Kiovig® …

Research ReportIVIgAdultMalemedicine.medical_specialtymultifocal motor neuropathyEquivalence Trials as Topiclaw.invention03 medical and health sciences0302 clinical medicineRandomized controlled trialDouble-Blind MethodlawInternal medicineOutcome Assessment Health CaremedicineClinical endpointHumansImmunologic FactorsMotor Neuron DiseaseAgedCross-Over StudiesMaintenance dosebusiness.industryGeneral NeuroscienceImmunoglobulins IntravenousResearch Reportsclinical trialMiddle AgedHaemolysismedicine.diseaseCrossover studyConfidence intervalTolerability030220 oncology & carcinogenesisFemaleNeurology (clinical)businessimmunoglobulin030217 neurology & neurosurgeryMultifocal motor neuropathyJournal of the Peripheral Nervous System
researchProduct

How can hepatitis C be prevented in the long term?

2007

Abstract Significant advances have been made in preventing HIV infection among injectors but we still know little about preventing hepatitis C (HCV). Both prevalence and incidence of hepatitis C can remain high among IDUs even in the context of widespread implementation of harm reduction programmes. We need to develop new ways to fill the knowledge gap regarding HCV prevention. One way is to learn from the experts—those IDUs who, after long-term injection in social milieus of high hepatitis C prevalence, nonetheless remain uninfected. We describe a recently commenced program of research that focuses on understanding the strategies, behaviours, and environmental factors associated with "stay…

Research designTime FactorsNational Health ProgramsInternational CooperationHealth BehaviorNew YorkHuman immunodeficiency virus (HIV)Medicine (miscellaneous)Context (language use)medicine.disease_causeArticleSocial supportHarm ReductionEnvironmental healthLondonPrevalencemedicineHumansSubstance Abuse IntravenousHarm reductionbusiness.industryIncidenceHealth PolicySocial SupportHepatitis CConceptual basismedicine.diseaseHepatitis CNeedle-Exchange ProgramsSocioeconomic FactorsResearch DesignSpainNew South WalesbusinessQualitative researchInternational Journal of Drug Policy
researchProduct

Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.

2020

Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic Mboat7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2 hepatocytes. Findings: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammatio…

Research paperTGFβ Transforming Growth Factor BetaIntracellular SpaceCRISPR Clustered Regularly Interspaced Short Palindromic RepeatshHEPS Human HepatocytesMice0302 clinical medicineLPIAT1DAG Diacylglyceroli.p. Intraperitonealmedia_commonFatty AcidsGeneral Medicine3. Good health030220 oncology & carcinogenesisHOMA-IR homeostasis Model Assessment of Insulin ResistanceMPO morpholinolcsh:Medicine (General)medicine.medical_specialtyPE Phosphatidyl-EthanolamineNashGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesTNFα tumor Necrosis Factor AlphaLDL Low Density LipoproteinsHyperinsulinismNAFLDSD Standard Dietmedia_common.cataloged_instanceHumansCPT1 Carnitine Palmitoyltransferase IPhosphatidylinositolGene SilencingEuropean unionVLDL Very Low Density Lipoproteinlcsh:RhHSC Human Hepatic Stellate Cellsmedicine.diseaseLipid MetabolismOA Oleic AcidCI Confidence IntervalMboat7 Membrane bound O-acyltransferase domain containing 7MCD methionine choline deficient diet030104 developmental biologyEndocrinologychemistryCDP Cytidine-DiphosphateFOXO1 Forkhead Box protein O1NAFLD nonalcoholic fatty liver diseaseSteatohepatitisBMI Body Mass IndexCL CardiolipinAcyltransferases0301 basic medicineAlcoholic liver diseaseCXCL10 C-X-C Motif Chemokine 10lcsh:Medicinechemistry.chemical_compoundNon-alcoholic Fatty Liver DiseaseIFG Impaired Fasting GlucoseAPOB Apolipoprotein BNonalcoholic fatty liver diseasePIP Phosphatidyl-Inositol-PhosphateSteatohepatitisqRT-PCR quantitative Real Time Polymerase Chain ReactionMice Knockoutlcsh:R5-920ORO Oil Red O StainingPI PhosphatidylinositolFatty liverTM6SF2 Transmembrane 6 Superfamily Member 2PhospholipidTAG TriglyceridesNASH Nonalcoholic SteatohepatitisLipogenesisLPA Lyso-Phosphatidic AcidPhosphatidylinositolSignal TransductionPS Phosphatidyl-SerinePA Palmitic AcidALD alcoholic liver diseasePC Phosphatidylcholinei.v. IntravenousFATP1 Fatty Acid Transport Protein 1Models BiologicalInternal medicinemedicineAnimalsNonalcoholic fatty liver diseasePPARα Peroxisome Proliferator-Activated Receptor alphaObesityG3P Glyceraldehyde-3-PhosphateSREBP1c Sterol Regulatory Element-Binding Protein 1HDL High Density Lipoproteinsbusiness.industryPI3K Phosphatidylinositol 3 KinaseMembrane ProteinsNHEJ Non-Homologues End JoiningPNPLA3 Patatin-like Phospholipase Domain-containing-3MTTP Microsomal Triglyceride Transfer ProteinLPIAT1 Lysophosphatidylinositol Acyltransferase 1TMC4 Transmembrane Channel-Like 4Disease Models AnimalGene Expression RegulationHepatocytesFOXA2 Forkhead Box A2mTOR mammalian target of RapamycinSteatosisInsulin ResistancebusinessPG Phosphatidyl-GlycerolFABP1 Fatty Acid-Binding Protein 1 FAS Fatty Acid SynthaseT2DM Type 2 Diabetes MellitusEBioMedicine
researchProduct

Nurse knowledge and confidence on peripheral intravenous catheter insertion and maintenance in pediatric patients: A multicentre cross-sectional study

2021

Abstract Purpose To examine nursing knowledge and confidence of peripheral intravenous catheter insertion and maintenance in pediatric patients. Design and methods An online survey using validated questionnaires was conducted in ten (tertiary and district) hospitals in Indonesia from May to September 2020. Multivariable general linear models were used to investigate associations between nurses' characteristics and knowledge and confidence on the catheter insertion and maintenance score. Results A total of 413 out of 458 pediatric nurses completed the survey (a response rate of 90%). The mean score of the nurse knowledge on insertion was 18.9(±3.3) (maximum score: 21), and the maintenance sc…

Response rate (survey)CathetersCatheter insertionPeripheral intravenousCross-sectional studybusiness.industryNursesPatient assessmentPediatricsWork experienceCatheterCross-Sectional StudiesNursingSurveys and QuestionnairesPediatric NursesCatheterization PeripheralHumansMedicineClinical CompetenceChildbusinessJournal of Pediatric Nursing
researchProduct

Alpha-adrenergic drugs in retrograde ejaculation.

1974

6 men with complete or partial loss of ejaculation as a result of retroperitoneal lymphadenectomy (performed because of testicular tumor) were treated with an intravenous injection of 60 mg synephrine. Synephrine stimulates adrenergic alpha-receptors. Only 1 man with sustained retrograde ejaculation improved following treatment showing antegrade ejaculation. This temporary restoration of fertility was thought to be due to an increase in bladder neck tone and prevention of backflow of semen into the bladder as a result of stimulation of adrenergic alpha-receptors.

Retrograde ejaculationInfertilityAdultMalemedicine.medical_specialtyEjaculationPopulationUrologyAdrenergicSemenStimulationCell CountUrineurologic and male genital diseasesMedicineHumansEjaculationeducationeducation.field_of_studybusiness.industrySynephrineObstetrics and Gynecologymedicine.diseaseSpermatozoaSurgeryMasturbationNeck of urinary bladderReproductive MedicineSurgical Procedures OperativeInjections IntravenousLymph Node ExcisionGenital Diseases MalebusinessFertility and sterility
researchProduct

Ten-month follow-up of patients with covid-19 temporally related multi-system inflammatory syndrome in children: the experience of the children hospi…

2023

Abstract Background In Sicily, the first wave of COVID-19 showed a low epidemic impact in paediatric population, while the second and the third waves had a higher impact on clinical presentation of COVID-19 in children and a significantly higher severe outcome in patients with multisystem inflammatory syndrome in children (MIS-C), with a frequent life-threatening progression. Methods We describe a cohort of 22 Sicilian children (11 M; 11 F; age: 1.4–14 years), presenting with clinical features compatible with MIS-C. Patients with negative swab had a history of recent personal or parental infection. Results The following diagnostic criteria were detected: fever (100%); cheilitis and/or phary…

Settore MED/38 - Pediatria Generale E SpecialisticaGeneral MedicineCOVID-19 Intravenous immunoglobulin Kawasaki disease Methylprednisolone Multisystem inflammatory syndrome in children (MIS-C) SARS-CoV-2Italian Journal of Pediatrics
researchProduct

Antibodies to human herpes virus type 8 (HHV8) in general population and in individuals at risk for sexually transmitted diseases in Western Sicily.

2000

Human herpes virus 8 (HHV8) appears to be the primary aetiologic agent of Kaposi sarcoma (KS). To study the distribution of HHV8, a seroepidemiological study was carried out in western Sicily, where a high incidence rate of classical KS is well documented.A total of 970 sera of healthy human immunodeficiency virus (HIV) negative individuals of general population (1-70 years old) and 742 sera of individuals in different risk groups for HIV infection were evaluated by means of an indirect immunofluorescence assay able to detect antibodies to lytic and latent HHV8 antigens.Crude seroprevalence to HHV8 antigens was 11.5% in the general population, and it increased significantly with age from 6%…

Sexually transmitted diseaseAdultMalemedicine.medical_specialtyAdolescentEpidemiologyPopulationSexually Transmitted DiseasesHIV InfectionsSerologyRisk FactorsSeroepidemiologic StudiesEpidemiologyMedicineSeroprevalenceHumansRisk factorHomosexuality MaleeducationChildSubstance Abuse IntravenousSarcoma KaposiSicilyAgededucation.field_of_studybusiness.industryTransmission (medicine)InfantGeneral MedicineHerpesviridae InfectionsMiddle AgedSex WorkHeterosexualityChild PreschoolImmunologyHerpesvirus 8 HumanFemalebusinessDemographyInternational journal of epidemiology
researchProduct

Auditory brain stem responses in patients with human immunotropic virus infection of different stages.

1992

Thirty patients (26 men, 4 women) with human immunotropic virus infection of different stages were examined. Eleven patients had a history of i.v. drug abuse, nine patients had a history of treated lues infection, and one patient suffered from Kaposi's sarcoma. At the time of the examination, opportunistic infections or acute encephalitis were not apparent in any patient. All patients underwent otoneurological examinations, including pure-tone audiometry, caloric vestibular testing, and recording of the auditory brain stem responses (ABR). Six patients reported onset of hearing impairment during the last 3 yr. Two of them had flat sensorineural hearing loss; in the other cases, pure-tone au…

Sexually transmitted diseaseAdultMalemedicine.medical_specialtyPathologyAuditory PathwaysHearing lossDiseaseAudiologySpeech and HearingImmunopathologyotorhinolaryngologic diseasesmedicineCaloric TestsEvoked Potentials Auditory Brain StemHumansHearing Loss CentralSubstance Abuse IntravenousAcquired Immunodeficiency Syndromemedicine.diagnostic_testbusiness.industryTherapeutic effectMiddle Agedmedicine.diseaseOtorhinolaryngologyAudiometry Pure-ToneSensorineural hearing lossFemaleViral diseaseAudiometrymedicine.symptombusinessEar and hearing
researchProduct