6533b7d5fe1ef96bd1264897

RESEARCH PRODUCT

Alpha-adrenergic drugs in retrograde ejaculation.

Karl StockampJens E. AltweinFriedhelm Schreiter

subject

Retrograde ejaculationInfertilityAdultMalemedicine.medical_specialtyEjaculationPopulationUrologyAdrenergicSemenStimulationCell CountUrineurologic and male genital diseasesMedicineHumansEjaculationeducationeducation.field_of_studybusiness.industrySynephrineObstetrics and Gynecologymedicine.diseaseSpermatozoaSurgeryMasturbationNeck of urinary bladderReproductive MedicineSurgical Procedures OperativeInjections IntravenousLymph Node ExcisionGenital Diseases Malebusiness

description

6 men with complete or partial loss of ejaculation as a result of retroperitoneal lymphadenectomy (performed because of testicular tumor) were treated with an intravenous injection of 60 mg synephrine. Synephrine stimulates adrenergic alpha-receptors. Only 1 man with sustained retrograde ejaculation improved following treatment showing antegrade ejaculation. This temporary restoration of fertility was thought to be due to an increase in bladder neck tone and prevention of backflow of semen into the bladder as a result of stimulation of adrenergic alpha-receptors.

yearjournalcountryeditionlanguage
1974-09-01Fertility and sterility
10.1016/s0015-0282(16)40638-2https://pubmed.ncbi.nlm.nih.gov/4417493