Search results for "Ipf"
showing 10 items of 16 documents
Idiopathic Pulmonary Fibrosis and Lung Cancer: Mechanisms and Molecular Targets
2019
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary disease with a median survival of 2–4 years after diagnosis. A significant number of IPF patients have risk factors, such as a history of smoking or concomitant emphysema, both of which can predispose the patient to lung cancer (LC) (mostly non-small cell lung cancer (NSCLC)). In fact, IPF itself increases the risk of LC development by 7% to 20%. In this regard, there are multiple common genetic, molecular, and cellular processes that connect lung fibrosis with LC, such as myofibroblast/mesenchymal transition, myofibroblast activation and uncontrolled proliferation, endoplasmic reticulum stress, alterat…
Subtitling and dubbing as teaching resources for learning English as a foreign language using Clipflair software
2020
[EN] The research validity of using clips as audiovisual material to teach a foreign language has been demonstrated by many scholars. At the same time, the combination of this material with two modalities of audiovisual translation (AVT) - subtitling and dubbing- is worth exploring. The aim of this study is to present the effectiveness of subtitling and dubbing activities as tools for teaching English as a foreign language. In order to do so, a number of participants from the University of Valencia (Spain) whose level of English was B2/B2+ were engaged in a combination of subtitling and dubbing activities. I devised a series of tasks based on a two-minute subtitled video-clip, designed to i…
Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide.
2020
Obesity has reached epidemic proportions in the United States and in much of the westernized world, contributing to considerable morbidity. Several of these obesity-related morbidities are associated with greater risk for death with coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 penetrates human cells through direct binding with angiotensin-converting enzyme 2 receptors on the cell surface. Angiotensin-converting enzyme 2 expression in adipose tissue is higher than that in lung tissue, which means that adipose tissue may be vulnerable to COVID-19 infection. Obese patients also have worse outcomes with COVID-19 infection, including respiratory failure, n…
In Vivo Nuclear Imaging of Hypoxia as Predictive Biomarkers and follow up the Response to Anti-VEGF Therapies in Idiopathic Pulmonary Fibrosis
2022
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal disease of unknown origin. In France, it is one of the most common interstitial pathologies (IP) and affects 4,400 new people each year. IPF is characterized by dysregulated healing mechanisms that lead to the accumulation of large amounts of collagen in the lung tissue and cause disorganization of the alveolar architecture. It results in progressive deterioration of the respiratory function, leading in a few years to chronic respiratory failure and then to death. Idiopathic pulmonary fibrosis has a lower survival rate than many cancers with a median survival of 2 to 5 years from diagnosis. This pathology whose main ris…
Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis
2022
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by an abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis within the alveolar wall that are not due to infection or cancer. Oxidative stress has been proposed as a key molecular process in pulmonary fibrosis development and different components of the redox system are altered in the cellular actors participating in lung fibrosis. To this respect, several activators of the antioxidant machinery and inhibitors of the oxidant species and pathways have been assayed in preclinicalin vitroandin vivomodels and in different clinical trials. This review discusses the role of …
The impact of SARS-COV2 pandemic on the management oF IPF patients: Our narrative experience
2021
Abstract Background The SARS-CoV-2 pandemic has changed the health-care systems around the world in a remarkable way. We describe the strategies adopted to cope with the limitations imposed by the pandemic to the access to health care by patients diagnosed with idiopathic Pulmonary Fibrosis (IPF). Material and methods We conducted a retrospective observational analysis including IPF patients under antifibrotic drugs (nintedanib and pirfenidone) that accessed to the Outpatient clinic of the University of Palermo, Italy. Patients received a phone number and an email address in case of any urgency and a virtual meeting was settled up monthly. Results 40 patients (M/F: 30/10) were followed up, …
Extracellular Heat Shock Proteins as Therapeutic Targets and Biomarkers in Fibrosing Interstitial Lung Diseases.
2021
Interstitial lung diseases (ILDs) include a large number of diseases and causes with variable outcomes often associated with progressive fibrosis. Although each of the individual fibrosing ILDs are rare, collectively, they affect a considerable number of patients, representing a significant burden of disease. Idiopathic pulmonary fibrosis (IPF) is the typical chronic fibrosing ILD associated with progressive decline in lung. Other fibrosing ILDs are often associated with connective tissues diseases, including rheumatoid arthritis-ILD (RA-ILD) and systemic sclerosis-associated ILD (SSc-ILD), or environmental/drug exposure. Given the vast number of progressive fibrosing ILDs and the dispariti…
Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms
2021
Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway is activated under the interaction of a broad number of profibrotic/pro-inflammatory cytokines, such as IL-6, IL-11, and IL-13, among others, which are increased in different ILDs. Similarly, several growth factors over-expressed in ILDs, such as platelet-derived growth factor (PDGF), transforming growth factor β1 (TGF-β1), and fibroblast growth factor (FGF) activate JAK/STAT by canonical or non-canonical pathways, which indicates a predominant role of JAK/STAT in ILDs. Between the different JAK/STAT iso…
Comparison of MeSH terms and KeyWords Plus terms for more accurate classification in medical research fields. A case study in cannabis research
2021
Abstract KeyWords Plus and Medical Subject Headings (MeSH) are widely used in bibliometric studies for topic mapping. The objective of this study is to compare the two description systems in documents about cannabis research to find the concordance between systems and establish whether there is neutrality in topic mapping. A total of 25,593 articles from 1970 to 2019 were drawn from Web of Science's Core Collection and Medline and analyzed. The tidytext library, Zipf's law, topic modeling tools, the contingency coefficient, Cramer's V, and Cohen's kappa were used. The results included 10,107 MeSH terms and 28,870 KeyWords Plus terms. The Zipf distribution of the terms was different for each…
"Que inventen ellos"
2011
Malgrat la relació existent entre la inversió en ciència i tecnologia i el desenvolupament econòmic d’una societat, per a la Generalitat Valenciana la ciència és un afegit bonic que pot fer somiar però que no porta diners immediats. Per això han deixat amb un pressupost insuficient el Centre d'Investigació Principe Felipe (CIPF), cosa que ha comportat l'acomiadament de 114 investigadors i tècnics reconeguts internacionalment. Although a clear relationship exists between investment in science and technology and economic development of society, for the Generalitat Valenciana (Valencian Government) science is a nice addition that makes dream but can not bring immediate cash. Therefore they hav…