Search results for "Isonicotinamide"
showing 7 items of 7 documents
Pimasertib Versus Dacarbazine in Patients With Unresectable NRAS-Mutated Cutaneous Melanoma: Phase II, Randomized, Controlled Trial with Crossover
2020
This study investigated the efficacy and safety of pimasertib (MEK1/MEK2 inhibitor) versus dacarbazine (DTIC) in patients with untreated NRAS-mutated melanoma. Phase II, multicenter, open-label trial. Patients with unresectable, stage IIIc/IVM1 NRAS-mutated cutaneous melanoma were randomized 2:1 to pimasertib (60 mg
Copper(II)-phenylmalonate complexes with the bifunctional ligands nicotinamide and isonicotinamide
2011
Abstract The use as coligands of the nicotinamide (nia) and isonicotinamide (inia) molecules in the complex formation between copper(II) and phenylmalonate [Phmal = dianion of phenylmalonic acid] yielded the compounds of formula [Cu(inia)(Phmal)(H2O)] (1) and [Cu(inia)(Phmal)(H2O)]n (2). Although single crystals of 1 of appropriate size were grown, their unresolved twinning and space group ambiguity prevented a satisfactory X-ray structure determination. The crystal structure 2 consists of corrugated layers of copper(II) ions with intralayer carboxylate–phenylmalonate bridges in the anti-syn (equatorial-apical) coordination mode. A water molecule and the isonicotinamide group are coordinate…
Influence of Host-Guest and Host-Host Interactions on the Spin-Crossover 3D Hofmann-type Clathrates {FeII(pina)[MI(CN)2]2·xMeOH (MI = Ag, Au)
2019
[EN] The synthesis, structural characterization and magnetic properties of two new isostructural porous 3D compounds with the general formula {FeII(pina)[MI(CN)2]2}·xMeOH (x = 0¿5; pina = N-(pyridin-4-yl)isonicotinamide; MI = AgI and x ~ 5 (1·xMeOH); MI = AuI and x ~ 5 (2·xMeOH)) are presented. The single-crystal X-ray diffraction analyses have revealed that the structure of 1·xMeOH (or 2·xMeOH) presents two equivalent doubly interpenetrated 3D frameworks stabilized by both argentophilic (or aurophilic) interactions and interligand C¿O···HC H-bonds. Despite the interpenetration of the networks, these compounds display accessible void volume capable of hosting up to five molecules of methano…
The electrochemical reduction of thioisonicotinamide in an aqueous medium
1998
Abstract The electrochemical reduction of thioisonicotinamide NRCSNH 2 has been examined in an aqueous medium between H 0 =−1 and pH=13.7. As shown by cyclic voltammetry and polarography, a global 2e − reversible transfer is followed by two successive first-order chemical reactions and a 2e − , 2H + reduction (EC 1 C 2 E process). A mechanism is proposed, beginning with the 2e − reduction of NRCSNH 2 to the formal diionized form NRC − (SH)(NH 3 + ), the first chemical reaction, C 1 , being a formal proton transfer which yields the 4- gem aminosulfanylmethylpyridine; the rate constant of this reaction is 2×10 4 s −1 in acidic medium and diminishes in neutral medium. The second process, C 2 …
CCDC 1058520: Experimental Crystal Structure Determination
2015
Related Article: Alexandre Abhervé, Mario Palacios-Corella, Juan Modesto Clemente-Juan, Raphael Marx, Petr Neugebauer, Joris van Slageren, Miguel Clemente-León, Eugenio Coronado|2015|J.Mater.Chem.C|3|7936|doi:10.1039/C5TC01089F
CCDC 765760: Experimental Crystal Structure Determination
2011
Related Article: J.Pasan, J.Sanchiz, F.Lloret, M.Julve, C.Ruiz-Perez|2011|Polyhedron|30|2451|doi:10.1016/j.poly.2011.06.006
CCDC 1058519: Experimental Crystal Structure Determination
2015
Related Article: Alexandre Abhervé, Mario Palacios-Corella, Juan Modesto Clemente-Juan, Raphael Marx, Petr Neugebauer, Joris van Slageren, Miguel Clemente-León, Eugenio Coronado|2015|J.Mater.Chem.C|3|7936|doi:10.1039/C5TC01089F