Pimasertib Versus Dacarbazine in Patients With Unresectable NRAS-Mutated Cutaneous Melanoma: Phase II, Randomized, Controlled Trial with Crossover

6533b834fe1ef96bd129ccc3

RESEARCH PRODUCT

Pimasertib Versus Dacarbazine in Patients With Unresectable NRAS-Mutated Cutaneous Melanoma: Phase II, Randomized, Controlled Trial with Crossover

Céleste Lebbé Armin Schueler Richard Isaacs Giorgio Massimini Willem Kruit Brigitte Dreno Virginia Ferraresi Caroline Robert Luc Thomas Enrique Espinosa Carmen Loquai Paul Vasey Joseph Kerger Bernard Guillot Jean-jacques Grob Robert M. Conry Caroline Dutriaux Claus Garbe Filippo De Braud Thierry Lesimple

subject

Cancer Research Gastroenterology pimasertib law.invention 0302 clinical medicine Randomized controlled trial law Clinical endpoint 030212 general & internal medicine Malignant melanoma Hazard ratio Progression-free survival Sciences bio-médicales et agricoles lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 3. Good health Dacarbazine Oncology [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology 030220 oncology & carcinogenesis medicine.symptom Pimasertib medicine.drug Quality of life medicine.medical_specialty Nausea Dacarbazine malignant melanoma dacarbazine [SDV.CAN]Life Sciences [q-bio]/Cancer N-(2 3-dihydroxypropyl)-1-((2-fluoro-4-iodophenyl)amino)isonicotinamide Neutropenia N-(2 3-dihydroxypropyl)-1-((2-fluoro-4-iodophenyl)amino)isonicotinamide lcsh:RC254-282 Article 03 medical and health sciences [SDV.CAN] Life Sciences [q-bio]/Cancer Internal medicine medicine Progression-free survival Adverse effect business.industry [SDV.MHEP.DERM] Life Sciences [q-bio]/Human health and pathology/Dermatology medicine.disease adverse events Cancérologie quality of life Adverse events [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology business progression-free survival [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology

description

This study investigated the efficacy and safety of pimasertib (MEK1/MEK2 inhibitor) versus dacarbazine (DTIC) in patients with untreated NRAS-mutated melanoma. Phase II, multicenter, open-label trial. Patients with unresectable, stage IIIc/IVM1 NRAS-mutated cutaneous melanoma were randomized 2:1 to pimasertib (60 mg

year	journal	country	edition	language
2020-06-29

10.3390/cancers12071727 https://hal.umontpellier.fr/hal-03256625

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