Search results for "Isotopes"

showing 10 items of 1216 documents

Heavy enzymes and the rational redesign of protein catalysts

2019

Abstract An unsolved mystery in biology concerns the link between enzyme catalysis and protein motions. Comparison between isotopically labelled “heavy” dihydrofolate reductases and their natural‐abundance counterparts has suggested that the coupling of protein motions to the chemistry of the catalysed reaction is minimised in the case of hydride transfer. In alcohol dehydrogenases, unnatural, bulky substrates that induce additional electrostatic rearrangements of the active site enhance coupled motions. This finding could provide a new route to engineering enzymes with altered substrate specificity, because amino acid residues responsible for dynamic coupling with a given substrate present…

010402 general chemistryProtein Engineering01 natural sciencesBiochemistryCatalysisEnzyme catalysisisotope effectsCatalytic DomainDihydrofolate reductaseMolecular BiologyAlcohol dehydrogenasechemistry.chemical_classificationalcohol dehydrogenasesCarbon Isotopesdihydrofolate reductasesbiologyBacteriaNitrogen Isotopes010405 organic chemistryConceptOrganic ChemistryAlcohol DehydrogenaseActive siteSubstrate (chemistry)Protein engineeringDeuteriumCombinatorial chemistrymolecular dynamics0104 chemical sciencesKineticsTetrahydrofolate Dehydrogenaseenzyme engineeringEnzymechemistrybiology.proteinBiocatalysisMolecular MedicineConcepts
researchProduct

Annually resolved δ13Cshell chronologies of long-lived bivalve mollusks (Arctica islandica) reveal oceanic carbon dynamics in the temperate North Atl…

2011

Abstract The ability of the ocean to absorb carbon dioxide is likely to be adversely affected by recent climate change. However, relatively little is known about the spatiotemporal variability in the oceanic carbon cycle due to the lack of long-term, high-resolution dissolved inorganic carbon isotope ( δ 13 C DIC ) data, especially for the temperate North Atlantic, which is the major oceanic sink for anthropogenic CO 2 . Here, we report shell carbon isotope values ( δ 13 C shell ), a potential proxy for δ 13 C DIC , of old-grown specimens of the long-lived bivalve mollusk, Arctica islandica . This paper presents the first absolutely dated, annually resolved δ 13 C shell record from surface …

010504 meteorology & atmospheric sciences010502 geochemistry & geophysicsOceanography01 natural sciencesCarbon cycleSuess effectSclerochronologySclerochronology14. Life underwaterArctica islandicaEcology Evolution Behavior and Systematics0105 earth and related environmental sciencesEarth-Surface ProcessesPolar frontStable carbon isotope ratiobiologyOcean currentOceanic Suess effectPaleontologybiology.organism_classificationDissolved inorganic carbonOceanographyCarbon dioxide13. Climate actionIsotopes of carbon[SDE]Environmental SciencesOceanic carbon cycleGeology
researchProduct

Diagenetic stability of non-traditional stable isotope systems (Ca, Sr, Mg, Zn) in teeth – An in-vitro alteration experiment of biogenic apatite in i…

2021

Stable isotope ratios and trace element concentrations of fossil bones and teeth are important geochemical proxies for the reconstruction of diet and past environment in archaeology and palaeontology. However, since diagenesis can significantly alter primary diet-related isotope signatures and elemental compositions, it is important to understand and quantify alteration processes. Here, we present the results of in-vitro alteration experiments of dental tissues from a modern African elephant molar reacted in aqueous solutions at 30 °C and 90 °C for 4 to 63 days. Dental cubes with ≈ 3 mm edge length, comprising both enamel and dentin, were placed into 2 mL of acidic aqueous sol…

010504 meteorology & atmospheric sciencesAnalytical chemistry010502 geochemistry & geophysics01 natural sciencesApatiteDiagenesischemistry.chemical_compoundstomatognathic systemIsotopesGeochemistry and PetrologyDentinmedicineBioapatite0105 earth and related environmental sciencesIsotopeEnamel paintStable isotope ratioTrace elementLA-(MC-)ICP-MSGeologyHydroxylapatitestomatognathic diseasesmedicine.anatomical_structurechemistry13. Climate actionvisual_artRaman spectroscopyvisual_art.visual_art_mediumEPMAGeologyEMPA
researchProduct

Inter-annual climate variability in Europe during the Oligocene icehouse

2017

Abstract New sclerochronological data suggest that a variability comparable to the North Atlantic Oscillation (NAO) was already present during the middle Oligocene, about 20 Myr earlier than formerly assumed. Annual increment width data of long-lived marine bivalves of Oligocene (30–25 Ma) strata from Central Europe revealed a distinct quasi-decadal climate variability modulated on 2–12 (mainly 3–7) year cycles. As in many other modern bivalves, these periodic changes in shell growth were most likely related to changes in primary productivity, which in turn, were coupled to atmospheric circulation patterns. Stable carbon isotope values of the shells (δ 13 C shell ) further corroborated the …

010504 meteorology & atmospheric sciencesAtmospheric circulationPaleontology010502 geochemistry & geophysicsOceanography01 natural sciencesProxy (climate)Oceanography13. Climate actionNorth Atlantic oscillationIsotopes of carbonSclerochronologyClimatologyClimate model14. Life underwaterClimate stateCenozoicEcology Evolution Behavior and SystematicsGeology0105 earth and related environmental sciencesEarth-Surface ProcessesPalaeogeography, Palaeoclimatology, Palaeoecology
researchProduct

Environmental and biological factors are joint drivers of mercury biomagnification in subarctic lake food webs along a climate and productivity gradi…

2021

Subarctic lakes are getting warmer and more productive due to the joint effects of climate change and intensive land-use practices (e.g. forest clear-cutting and peatland ditching), processes that potentially increase leaching of peat- and soil-stored mercury into lake ecosystems. We sampled biotic communities from primary producers (algae) to top consumers (piscivorous fish), in 19 subarctic lakes situated on a latitudinal (69.0-66.5 degrees N), climatic (+3.2 degrees C temperature and +30% precipitation from north to south) and catchment land-use (pristine to intensive forestry areas) gradient. We first tested how the joint effects of climate and productivity influence mercury biomagnific…

010504 meteorology & atmospheric sciencesBiomagnificationTROPHIC POSITIONmaankäyttö010501 environmental sciencesMETHYLMERCURY01 natural sciencesFood chainBiological FactorsONTARIO LAKESCHAIN STRUCTUREClimate changeympäristömyrkytWaste Management and DisposalLand-useApex predatorTrophic levelkalatStable isotopes2. Zero hungerFRESH-WATEREcologyFishesvesiekosysteemitBIOACCUMULATIONselkärangattomatPollutionSubarctic climateclimate changeProductivity (ecology)Environmental MonitoringFood chain lengthEnvironmental EngineeringFood Chainelohopeachemistry.chemical_elementstable isotopeskasautuminenWHITEFISHland-useEnvironmental ChemistryAnimalsravintoketjutEcosystem1172 Environmental sciences0105 earth and related environmental sciencesfishfood chain lengthLake ecosystemMercury15. Life on landilmastonmuutoksetCHARR SALVELINUS-ALPINUSinvertebratesInvertebratesMercury (element)LakesFishchemistryisotooppianalyysi13. Climate actionEnvironmental scienceMARINEWater Pollutants Chemical
researchProduct

Changements environnementaux survenant à la limite Oligocène/Miocène du bassin des Limagnes (Massif central, France).

2018

16 pages; International audience; Continental environments are very sensitive to climatic variations. A unique opportunity to study the climate changes around the Oligocene/Miocene boundary is offered by the Limagne graben Basin (France) where this stage boundary is well constrained by fossils. Indeed, some localities of the Limagne Graben Basin are so rich in mammal remains that they have become a European reference for mammal biostratigraphy. The dominant sedimentary facies of the lacustrine deposits in the northern part of the Limagne Graben Basin are composed of poorly cemented marls and calcarenites containing various plants and animals remains (e.g. algae, fish bones and teeth, gastro…

010504 meteorology & atmospheric sciencesContext (language use)Biostratigraphy010502 geochemistry & geophysics01 natural sciencesPaleontology[SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistrycarbonates lacustresMarl14. Life underwaterstromatolitebassin des Limagnes0105 earth and related environmental sciencesPalynologygeographygeography.geographical_feature_categoryLimagne Basinisotopes de l’oxygènebiologylimite oligo-miocèneoxygen isotopeslcsh:QE1-996.5GeologyMassif15. Life on landbiology.organism_classificationlacustrine carbonateGrabenlcsh:GeologyStromatolite13. Climate action[SDU.STU.ST]Sciences of the Universe [physics]/Earth Sciences/StratigraphyapatitePeriod (geology)Oligocene/Miocene boundarybiozoneGeologyBSGF - Earth Sciences Bulletin
researchProduct

Interpretation of the nitrogen isotopic composition of Precambrian sedimentary rocks: Assumptions and perspectives

2016

International audience; Nitrogen isotope compositions in sedimentary rocks (d(15)N(sed)) are routinely used for reconstructing Cenozoic N-biogeochemical cycling and are also being increasingly applied to understanding the evolution of ancient environments. Here we review the existing knowledge and rationale behind the use of d(15)N(sed) as a proxy for the Precambrian N-biogeochemical cycle with the aims of (i) identifying the major uncertainties that affect analyses and interpretation of nitrogen isotopes in ancient sedimentary rocks, (ii) developing a framework for interpreting the Precambrian d(15)N(sed) record, (iii) testing this framework against a database of Precambrian d(15)N(sed) va…

010504 meteorology & atmospheric sciencesEarth scienceNitrogen isotopesMetamorphismGeologyNitrogen biogeochemical cycle010502 geochemistry & geophysicsEarly Earth01 natural sciencesIsotopes of nitrogenDiagenesisPaleontologyPrecambrianGeologic time scale13. Climate actionGeochemistry and Petrology[SDU]Sciences of the Universe [physics]Ocean oxygenationSedimentary rock14. Life underwaterPrecambrianCenozoicGeology[ SDU ] Sciences of the Universe [physics]0105 earth and related environmental sciences
researchProduct

Soil development on sediments and evaporites of the Messinian crisis

2020

Abstract Vast areas in the Mediterranean are characterised by evaporite deposits of the Messinian crises (c. 6–5.3 Ma BP). During this period, large deposits were built up in shallow lagoon-like systems and are now found in southern Italy, Albania, Cyprus and Turkey. So far, soil formation on evaporites has been studied predominantly in subarid to arid environments. Although the formation of soils has received new significance, little is known about the evolutional trajectories on evaporites of the Mediterranean. We therefore studied soil formation in the Caltanissetta basin (Sicily) where evaporites are most widespread. The lithologies included the sequence: marine clay deposits, laminated…

010504 meteorology & atmospheric sciencesEvaporite1904 Earth-Surface ProcessesGeochemistryEarthWeathering04 agricultural and veterinary sciences01 natural sciencesDiagenesis10122 Institute of GeographyPedogenesisSurface ProcessesSettore AGR/14 - PedologiaSoil formation Evaporites Clay mineralogy Weathering Diatomite Stable isotopes CarbonatesLeaching (pedology)Marl040103 agronomy & agriculture0401 agriculture forestry and fisheriesKaoliniteAridisol910 Geography & travelGeology0105 earth and related environmental sciencesEarth-Surface Processes
researchProduct

Impact of basin burial and exhumation on Jurassic carbonates diagenesis on both sides of a thick clay barrier (Paris Basin, NE France).

2014

27 pages; International audience; Several diagenetic models have been proposed for Middle and Upper Jurassic carbonates of the eastern Paris Basin. The paragenetic sequences are compared in both aquifers to propose a diagenetic model for the Middle and Late Jurassic deposits as a whole. Petrographic (optical and cathodoluminescence microscopy), structural (fracture orientations) and geochemical (δ18O, δ13C, REE) studies were conducted to characterize diagenetic cements, with a focus on blocky calcite cements, and their connection with fracturation events. Four generations of blocky calcite (Cal1-Cal4) are identified. Cal1 and Cal2 are widespread in the dominantly grain-supported facies of t…

010504 meteorology & atmospheric sciencesEvaporiteCarbonateStratigraphyGeochemistryJurassic[ SDU.STU.ST ] Sciences of the Universe [physics]/Earth Sciences/Stratigraphy010502 geochemistry & geophysicsOceanography01 natural sciencesDiagenesisPetrographyOxygen and carbon isotopesPaleontologychemistry.chemical_compoundParis Basin[ SDU.STU.MI ] Sciences of the Universe [physics]/Earth Sciences/MineralogyRare earth elements0105 earth and related environmental sciencesCalciteGeologyCementation (geology)6. Clean waterCretaceousDiagenesisGeophysicschemistry[SDU.STU.ST]Sciences of the Universe [physics]/Earth Sciences/StratigraphyFaciesEconomic GeologyPaleogeneGeology[SDU.STU.MI]Sciences of the Universe [physics]/Earth Sciences/Mineralogy
researchProduct

Petrographic and geochemical characterization of the Middle‒Upper Jurassic Fe–Mn crusts and mineralizations from Monte Inici (north-western Sicily): …

2021

AbstractFe–Mn concretions and mineralizations, associated with condensed horizons and hardground, are significant archives in ancient carbonate rocks. Their petro-chemical study allows an assessment of the palaeoenvironmental context in which they were formed also connected to their biotic or abiotic origin. At the western side of the Monte Inici (Fornazzo section, north-western Sicily) a well exposed outcrop of condensed pelagic limestones (Rosso Ammonitico facies: Middle‒Upper Jurassic) is well-known and thoroughly studied. In this section, the base of the Rosso Ammonitico facies consists of a very condensed level rich in fossils with a variable thickness deposited from the early Bathonia…

010504 meteorology & atmospheric sciencesGeochemistrySettore GEO/07 - Petrologia E PetrografiaContext (language use)engineering.material010502 geochemistry & geophysicsCarbonate hardgrounds01 natural sciencesDiagenesisPetrographyTodorokiteIsotopes of carbonFe–Mn crusts Frutexites Microbial mediation Mineralogy Trace elements REE Stable isotope Growth rateFaciesengineeringGeneral Earth and Planetary SciencesCarbonate rockGeology0105 earth and related environmental sciences
researchProduct