Search results for "Issues"
showing 10 items of 669 documents
Early motherhood: voices from female adolescents in the Hohoe Municipality, Ghana—a qualitative study utilizing Schlossberg’s Transition Theory
2020
ABSTRACT Purpose: Using Schlossberg’s Transition Theory, this study explored the lived experiences of pregnant adolescents and adolescent mothers coping strategies during their transition to motherhood. Methods: Based on a phenomenological perspective, this qualitative study used in-depth interviews (IDIs) and focus group discussions (FGDs) to answer the research aim. The process of data gathering included 8 FGDs and 12 IDIs held with adolescent mothers and pregnant adolescents. Audio recordings were transcribed and imported into MAXQDA 2018 for analysis. Results: Applying the interpretative phenomenologial analysis (IPA), four key themes emerged. This included: news of pregnancy; adolescen…
Bone Fusion in Normal and Pathological Development is Constrained by the Network Architecture of the Human Skull
2016
The premature fusion of cranial bones, craniosynostosis, affects the correct development of the skull producing morphological malformations in newborns. To assess the susceptibility of each craniofacial articulation to close prematurely, we used a network model of the skull to quantify the link reliability (an index based on stochastic block modeling and Bayesian inference) of each articulation. We show that, of the 93 human skull articulations at birth, the few articulations that are associated with nonsyndromic craniosynostosis conditions have statistically significant lower reliability scores than the others. In a similar way, articulations that close during the normal postnatal developm…
Automatic Extraction of Blood Vessels, Bifurcations and End Points in the Retinal Vascular Tree
2008
In this paper we present an effective algorithm for automated extraction of the vascular tree in retinal images, including bifurcations, crossovers and end-points detection. Correct identification of these features in the ocular fundus helps the diagnosis of important systematic diseases, such as diabetes and hypertension. The pre-processing consists in artefacts removal based on anisotropic diffusion filter. Then a matched filter is applied to enhance blood vessels. The filter uses a full adaptive kernel because each vessel has a proper orientation and thickness. The kernel of the filter needs to be rotated for all possible directions. As a consequence, a suitable kernel has been designed …
Net-Strikes: A Proposal for Re-orienting Social Struggles in the 21st Century
2020
The globalisation of the economy and the slow but steady loss of Nation-States’ power to global enterprises and financial capital force us to redefine strikes as a weapon for advancing social causes. The institutions legitimising this form of protest have changed greatly in the 21st Century. They must recoup their ability to change things if they are to remain an effective tool. The following paper reveals the reasons behind the decline of strikes in the modern world and proposes the ‘net-strike’ concept (or networked strike): a formula for bringing strikes up to date to meet today’s challenges.
Getting language awareness: A curriculum for language and language teaching for pre-service studies for teachers of mathematics
2018
International audience; As language is an important medium as well as an aim of mathematics lessons at school, teachers of mathematics have to achieve the required competencies in language and language teaching. Therefore, we designed a curriculum, which offers students opportunities to get these competencies throughout their academic studies. Some examples and first results will be shown.
Representing the Other in European Media Discourses
2017
This book deals with the construction of the ‘other’ in European media at a time when the recently expanded EU is facing new political, economic and social challenges. The aim of the book is to document the diverse discursive forms of othering, ranging from differentiation to discrimination, that are directed against various ‘other Europeans’ in both institutionalized media and such non-elite semi-public contexts as discussion forums and citizen blogs. Drawing on data from British, Polish, French, Czech, Italian, Hungarian, Spanish and Estonian contexts, the individual papers investigate how various social groupings – regions, nations, ethnicities, communities, cultures – are discursively c…
Overdiagnosis and overimaging: an ethical issue for radiological protection
2019
Aims and objectives: This study aimed to analyse the key factors that influence the overimaging using X-ray such as self-referral, defensive medicine and duplicate imaging studies and to emphasize the ethical problem that derives from it. Materials and methods: In this study, we focused on the more frequent sources of overdiagnosis such as the total-body CT, proposed in the form of screening in both public and private sector, the choice of the most sensitive test for each pathology such as pulmonary embolism, ultrasound investigations mostly of the thyroid and of the prostate and MR examinations, especially of the musculoskeletal system. Results: The direct follow of overdiagnosis and overi…
Low Levels of Acetylcholine Receptor Delta-Subunit Message and Protein in Human Thymus Suggests the Occurrence of ‘Triplet Receptors’ in Thymic Myoid…
2000
Myasthenia gravis (MG) is an autoimmune disease caused by autoantibodies against the acetylcholine receptor (AChR) at the neuromuscular junction [1]. The muscular AChR has been extensively characterized [2], but whether the muscular AChR plays a role during the initiation of MG is unknown [3]. The muscular AChR is a pentameric ion channel composed of 4 different subunits [2, 4]. The fetal AChR expressed during intrauterine life and after denervation of adult muscle exhibits an α2βδγ composition, while the adult AChR expressed after birth in innervated muscle exhibits an α2βδγ composition [4]. The α-subunit contains the main epitopes recognized by MG autoantibodies [2]. The human muscle AChR…
ChemInform Abstract: New Concepts in Multidentate Ligand Chemistry: Effects of Multidentarity on Catalytic and Spectroscopic Properties of Ferrocenyl…
2008
This tutorial review devoted to ligand chemistry deals with the design and properties of ferrocenyl polyphosphines, an original class of multidentate ligands. The development of a varied library of ferrocenyl tetra-, tri- and diphosphine ligands is reviewed. The multidentate nature of these species has led to unique spectroscopic and catalytic properties, in which the spatial proximity of phosphorus atoms is crucial. Regarding their catalytic applications, the key issues of catalyst longevity and ultralow catalyst loadings are discussed. Another part is concerned with fundamental advances gained in physical chemistry for structure elucidation by the study of the intriguing “through-space” N…
The ambivalent action of the anti-cancer agent 5-Fluorouracil on myeloid derived suppressor cells under control of docosahexaenoic acid : Role of NLR…
2018
A limitation to 5-Fluorouracil (5-FU) anti-cancer efficacy relies on the secretion of IL-1β by myeloid-derived suppressor cells (MDSC) according to a previous pre-clinical report. The release of mature IL-1β originates from 5 FU mediated NLRP3 activation with increased caspase-1 activity in MDSC and sustains tumor growth recovery in 5 FU treated mice. Docosahexaenoic acid (DHA) belongs to omega-3 fatty acid family and harbors both anti cancer and anti inflammatory properties which might could improve 5 FU chemotherapy. Here, we demonstrate that DHA inhibits 5 FU induced IL 1β secretion produced by a MDSC cell line (MSC-2). In tumor-bearing mice treated with 5 FU, we showed that a DHA enrich…