Search results for "Italy"
showing 10 items of 2893 documents
A museum system of design/craft for sustainable development in southern Italy
2018
Abstract: In this extended abstract we are going to explain an academic project entitled “THE SYSTEM OF TERRITORIAL DESIGN SYSTEMS. Cultural tourism, craftsmanship and design for the local development of the production enterprises of excellence in Southern Italy and Made in Italy”. It is based on the cooperation among designers and artisans in order to encourage the development of local craft- based production, by creating a REGIONAL MUSEUM SYSTEM OF DESIGN AND APPLIED ARTS in the five regions of Southern Italy. Then, the “SYSTEM OF THE SYSTEMS” is constituted of the five specific museum systems to be created in each region; these systems - especially in Campania and Sicily – can then repre…
The molecular profiling of solid tumors by liquid biopsy: a position paper of the AIOM–SIAPEC-IAP–SIBioC–SIC–SIF Italian Scientific Societies
2021
The term liquid biopsy (LB) refers to the use of various biological fluids as a surrogate for neoplastic tissue to achieve information for diagnostic, prognostic and predictive purposes. In the current clinical practice, LB is used for the identification of driver mutations in circulating tumor DNA derived from both tumor tissue and circulating neoplastic cells. As suggested by a growing body of evidence, however, there are several clinical settings where biological samples other than tissue could be used in the routine practice to identify potentially predictive biomarkers of either response or resistance to targeted treatments. New applications are emerging as useful clinical tools, and o…
The tumor-agnostic treatment for patients with solid tumors: a position paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIF Italian Scientific Societi…
2021
The personalized medicine is in a rapidly evolving scenario. The identification of actionable mutations is revolutionizing the therapeutic landscape of tumors. The morphological and histological tumor features are enriched by the extensive genomic profiling, and the first tumor-agnostic drugs have been approved regardless of tumor histology, guided by predictive and druggable genetic alterations. This new paradigm of "mutational oncology", presents a great potential to change the oncologic therapeutic scenario, but also some critical aspects need to be underlined. A process governance is mandatory to ensure the genomic testing accuracy and homogeneity, the economic sustainability, and the r…
Implementation of preventive and predictive BRCA testing in patients with breast, ovarian, pancreatic, and prostate cancer: a position paper of Itali…
2022
Constitutional BRCA1/BRCA2 pathogenic or likely pathogenic variants (PVs) are associated with an increased risk for developing breast and ovarian cancers. Current evidence indicates that BRCA1/2 PVs are also associated with pancreatic cancer, and that BRCA2 PVs are associated with prostate cancer risk. The identification of carriers of constitutional PVs in the BRCA1/2 genes allows the implementation of individual and family prevention pathways, through validated screening programs and risk-reducing strategies. According to the relevant and increasing therapeutic predictive implications, the inclusion of BRCA testing in the routine management of patients with breast, ovarian, pancreatic and…
The challenge of the Molecular Tumor Board empowerment in clinical oncology practice: A Position Paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIC-S…
2022
The development of innovative technologies and the advances in the genetics and genomics, have offered new opportunities for personalized treatment in oncology. Although the selection of the patient based on the molecular characteristics of the neoplasm has the potential to revolutionize the therapeutic scenario of oncology, this approach is extremely challenging. The access, homogeneity, and economic sustainability of the required genomic tests should be warranted in the clinical practice, as well as the specific scientific and clinical expertise for the choice of medical therapies. All these elements make essential the collaboration of different specialists within the Molecular Tumor Boar…
Position paper on laboratory testing for patients on direct oral anticoagulants. A Consensus Document from the SISET, FCSA, SIBioC and SIPMeL
2018
Although direct oral anticoagulants (DOAC) do not require dose-adjustment on the basis of laboratory test results, the measurement of their anticoagulant effect is useful in special situations. This position paper issued by the Italian Scientific Societies that are mainly involved in the management of patients on DOAC is aimed at providing guidance to care-givers on which tests should be used and the situations in which testing is useful. The guidance is based on the data from the literature so far available and/or on consensus among experts.
Prevalenza di sovrappeso e obesità in Italia: questione meridionale o disagio sociale?
2016
Overweight and obesity represent a topic of growing interest for most of the national healthcare plans of developed countries, mainly due to the increasing prevalence of overweight and obesity, and to their presence as a risk factor for many other noncommunicable diseases. The present work aims at providing a profile of overweight and obesity in Italy, and to analyze the impact of different territorial and socioeconomic risk factors. Data derived from Istat survey on “Health conditions and healthcare utilization” 2005 and 2013 are used, and Prevalence Risk Ratio estimates are derived through modified Poisson regression models. The results show higher prevalence of overweight and obesity in …
A Universal Health Care System? Unmet Need for Medical Care Among Regular and Irregular Immigrants in Italy
2017
Italy has a universal health care system that covers, in principle, the whole resident population, irrespective of citizenship and legal status. This study calculates the prevalence of unmet need for medical care among Italian citizens, regular and irregular immigrants and estimates logistic regression models to assess whether differences by citizenship and legal status hold true once adjusting for potential confounders. The analysis is based on two Surveys on Income and Living Conditions of Italian households and households with foreigners. Controlling for various factors, the odds of experiencing unmet need for medical care are 27% higher for regular immigrants than for Italian citizens a…
Diversification of diversity: Migrations, cultural pluralism and urban transformations in Palermo (Italy): a case study
2021
Italy experienced the transition from a country of emigration to a country of immigration only in the last decade of the 20th century. The extreme heterogeneity of the Italian scene – from the distribution and variety of productive sectors and local economic dimensions, to the geographical, cultural and linguistic varieties – results in an incredibly differentiated background on which the phenomenon of migrations fits as multiplier of diversity. But there are some particular fields in Italy where the challenges of superdiversity appear to be more prominent: the impact on the school system, in terms of linguistic-cultural pluralism; the change in religious belonging and identities; the dynam…
Phylogenetic analysis in the clinical risk management of an outbreak of hepatitis C virus infection among transfused thalassaemia patients in Italy
2021
Background: Occurrence of hepatitis C virus (HCV) infection is reduced by effective risk management procedures, but patient-to-patient transmission continues to be reported in healthcare settings. Aim: To report the use of phylogenetic analysis in the clinical risk management of an HCV outbreak among 128 thalassaemia outpatients followed at a thalassaemia centre of an Italian hospital. Methods: Epidemiological investigation and root-cause analysis were performed. All patients with acute hepatitis and known chronic infection were tested for HCV RNA, HCV genotyping, and NS3, NS5A, and NS5B HCV genomic region sequencing. To identify transmission clusters, phylogenetic trees were built for each…