Search results for "JOINT"

Specifications and validation of the ACMG/AMP criteria for clinical interpretation of sequence variants in collagen genes associated with joint hyper…

2023

Deleterious variants in collagen genes are the most common cause of hereditary connective tissue disorders (HCTD). Adaptations of the American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) criteria are still lacking. A multidisciplinary team was set up for developing specifications of the ACMG/AMP criteria for COL1A1, COL1A2, COL2A1, COL3A1, COL5A1, COL5A2, COL11A1, COL11A2 and COL12A1, associated with various forms of HCTD featuring joint hypermobility, which is becoming one of the most common reasons of referral for molecular testing in this field. Such specifications were validated against 209 variants, and resulted effective for classifying as p…

Avoiding accidents at the champagne reception: A study of joint lifting and balancing

2017

Using a lifting and balancing task, we contrasted two alternative views of planning joint actions: one postulating that joint action involves distinct predictions for self and other, the other postulating that joint action involves coordinated plans between the coactors and reuse of bimanual models. We compared compensatory movements required to keep a tray balanced when 2 participants lifted glasses from each other’s trays at the same time (simultaneous joint action) and when they took turns lifting (sequential joint action). Compared with sequential joint action, simultaneous joint action made it easier to keep the tray balanced. Thus, in keeping with the view that bimanual models are reu…

The Impact of Audit Committee Characteristics on the Enhancement of the Quality of Financial Reporting: an empirical study in the Spanish context

2007

The purpose of this paper is to analyse the relationship between the likelihood that a company will receive a qualified audit report (as a measure of the quality of financial information) and the existence and characteristics of the audit committee (AC). For listed companies that voluntarily created an AC in the period following the publication in 1998 of the Spanish Code of Corporate Governance, known as the Olivencia Code, we find that ACs size, the percentage of independent members in ACs, company size, losses reported in either or both of the previous two years, receiving the same qualified audit opinion as in the previous year and ownership concentration affect the likelihood of receiv…

2021

Functional proprioceptive information is required to allow an individual to interact with the environment effectively for everyday activities such as locomotion and object manipulation. Specifically, research suggests that application of compression garments could improve proprioceptive regulation of action by enhancing sensorimotor system noise in individuals of different ages and capacities. However, limited research has been conducted with samples of elderly people thus far. This study aimed to examine acute effects of wearing knee-length socks (KLS) of various compression levels on ankle joint position sense in community-dwelling, older adults. A total of 26 participants (12 male and 14…

VALUTAZIONE DELLA RESISTENZA DI ADESIONE E DELLA LUNGHEZZA EFFICACE DI INCOLLAGGIO NEI GIUNTI ADESIVI TRAMITE LE LEGGI DELL’EFFETTO SCALA

2010

In recent years, growing attention has been paid by researchers in structural mechanics to bonded joints in order to provide theoretical and numerical tools for better understanding the interfacial bonding/debonding phenomena. The research efforts in this area regard the formulation of reliable bond-slip models based on experimental data coming from laboratory tests performed on small specimens [1, 2]. As reported in [3], the mechanical quantities characterizing any interface constitutive law can be derived from the results of the experimental pull tests by a simple procedure making use of a schematization of the structural problem. The application to some single lap joint tests, carried ou…

Interactions and resonances in quantum systems

2017

This thesis book is concerned with the interactions and resonances in quantum systems and is subdivided into three thematics. First, our work is aimed at constructing in the local limit a systematic method for a normalized vibrational Hamiltonian for a strongly excited n-degree-of-freedom molecular system from the generators of the Lie algebra, the algebra of the invariant polynomials built in classical mechanics from the the kernel of the adjoint operator adH0 . We present both the method of construction in case of absence and in case of a p : q resonance system with n degrees of freedom. Application to the non-linear triatomic molecule ClOH is then given.On the other hand, by using the LT…

Association between condylar asymmetry and temporo- mandibular disorders using 3D-CT

2011

Objectives: Using reconstructed three-dimensional computed tomography (3D-CT) models, the purpose of this study was to analyze and compare mandibular condyle morphology in patients with and without temporomandibular disorder (TMD). Study Design: Thirty-two patients were divided into two groups: the first comprised those with TMD (n=18), and the second those who did not have TMD (n=14). A CT of each patient was obtained and reconstructed as a 3D model. The 64 resulting 3D condylar models were evaluated for possible TMD-associated length, width and height asymmetries of the condylar process. Descriptive statistics were used to assess the results and student’s t tests applied to compare the tw…

Reproducibility of imaging human knee cartilage by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5 Tesla

2009

Summary Objective The purpose of this study was to investigate the day-to-day reproducibility of the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) measurement at different knee joint surfaces in healthy subjects at 1.5 Tesla (T). Methods The dGEMRIC experiment was repeated for 10 asymptomatic volunteers three times with an average interval of 5 days between scans. The measurement was performed from a single sagittal slice through the center of the lateral femoral condyle and from the center of the patella in the axial plane. Cartilage was manually segmented into superficial, deep and full-thickness regions of interests (ROIs) at different topographical locations of the femur, tibia…

Facilitating cartilage volume measurement using MRI.

2010

To compare quantitative cartilage volume measurement (CVM) using different slice thicknesses.Ten knees were scanned with a 1.5T MRI (Sonata, Siemens, Erlangen, Germany) using a 3D gradient echo sequence (FLASH, fast low-angle shot). Cartilage volume of the medial and lateral tibial plateau was measured by two independent readers in 1.5mm, 3.0mm and 5.0mm slices using the Argus software application. Accuracy and time effectiveness served as control parameters.Determining cartilage volume, time for calculation diminished for the lateral tibial plateau from 384.6+/-127.7s and 379.1+/-117.6s to 214.9+/-109.9s and 213.9+/-102.2s to 122.1+/-60.1s and 126.8+/-56.2s and for the medial tibial platea…

EMG-Assisted Muscle Force Driven Finite Element Model of the Knee Joint with Fibril-Reinforced Poroelastic Cartilages and Menisci.

2019

Abnormal mechanical loading is essential in the onset and progression of knee osteoarthritis. Combined musculoskeletal (MS) and finite element (FE) modeling is a typical method to estimate load distribution and tissue responses in the knee joint. However, earlier combined models mostly utilize static-optimization based MS models and muscle force driven FE models typically use elastic materials for soft tissues or analyze specific time points of gait. Therefore, here we develop an electromyography-assisted muscle force driven FE model with fibril-reinforced poro(visco)elastic cartilages and menisci to analyze knee joint loading during the stance phase of gait. Moreover, since ligament pre-st…