Search results for "JUNCTION"
showing 10 items of 862 documents
Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development
2003
Neuregulins and their Erbb receptors have been implicated in neuromuscular synapse formation by regulating gene expression in subsynaptic nuclei. To analyze the function of Erbb2 in this process, we have inactivated the Erbb2 gene in developing muscle fibers by Cre/Lox-mediated gene ablation. Neuromuscular synapses form in the mutant mice, but the synapses are less efficient and contain reduced levels of acetylcholine receptors. Surprisingly, the mutant mice also show proprioceptive defects caused by abnormal muscle spindle development. Sensory Ia afferent neurons establish initial contact with Erbb2-deficient myotubes. However, functional spindles never develop. Taken together, our data su…
Intercellular communication and human hepatocellular carcinoma.
2005
We have previously reported that gap junction-mediated intercellular communication (GJIC) can be restored in junctionally deficient human prostate epithelial cells, also suggesting that GJIC activity is regulated by estrogen. In the present work, we report studies on sex steroid regulation of GJIC and proliferative activity in both nontumoral (Chang liver, CL) and malignant (HepG2, Huh7) human liver cells. Junctional activity and liver cell growth were measured using the scrape-loading/dye-transfer (SL/DT) and the MTS assay, respectively. Using the SL/DT, only Huh7 cells exhibited a moderate degree of Junctional activity in basic conditions, while neither CL nor HepG2 cells showed functiona…
Was King Arthur a King by Definition?
1988
Current research in knowledge representation distinguishes between descriptional and assertional interpretations of semantic nets. This paper explores theoretical and applicative problems, which arise from that distinction in a historic domain. A prolog implementation of KL-ONE is used as a vehicle to compare the various alternatives available to represent knowledge related to single elements of the domain insertion or not of this knowledge in semantic nets in their descriptional sense. The final section of the paper discusses the problem in relation to the theories concerning the functioning of proper names from a logical and philosophical point of view.
Nonlinear relaxation in quantum and mesoscopic systems
2013
The nonlinear relaxation of three mesoscopic and quantum systems are investigated. Specifically we study the nonlinear relaxation in: (i) a long Josephson junction (LJJ) driven by a non-Gaussian Lévy noise current; (ii) a metastable quantum open system driven by an external periodical driving; and (iii) the electron spin relaxation process in n-type GaAs crystals driven by a fluctuating electric field. In the first system the LJJ phase evolution is described by the perturbed sine-Gordon equation. Two well known noise induced effects are found: the noise enhanced stability and resonant activation phenomena. We investigate the mean escape time as a function of the bias current frequency, nois…
Reverse rotation of the right kidney associated with vascular anomaly producing ipsilateral ureteropelvic junction obstruction.
2009
La tutela della salubrità dell'aria e della persona in civil Law e in common Law
2022
The essay deals with safeguarding the right to a healthy environment in the Italian and English systems, especially for the individuals affected by emissions that corrupt the air quality interfering with their private and family life. The study focuses on the injunction, as a non-compensatory remedy, actionable before the English courts by claimants seeking the decontamination of the polluted areas. The insight into the foreign environmental law will provide a new perspective on the Italian one that (as the European Court of Human Rights stated in the Cordella case) does not secure everyone an effective remedy to the violation of their environmental human right.
Developement of new techniques of Optimal Control in Quantum Dynamics : from nuclear magnetic resonance to molecular physics
2011
The goal of this thesis is to apply the optimal control theory to the dynamics of quantum systems.The first part aim at introducing the tools of optimal control in quantum control which were initially developedin mathematics. This approch has been applied on different kinds of quantum system with small and largedimensions. The first part of this manuscript introduces the optimal control tools which are used with a pointof view suited to a public of physicists. In the second part these techniques are used to control the dynamics ofspins in NMR and MRI. The third part deals with the development of new iterative algorithms applied to thecontrol by laser fields of the rotational dynamics of lin…
Expression of the ALS-causing variant hSOD1G93A leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood–sp…
2015
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive paralysis due to the loss of primary and secondary motor neurons. Mutations in the Cu/Zn-superoxide dismutase (SOD1) gene are associated with familial ALS and to date numerous hypotheses for ALS pathology exist including impairment of the blood–spinal cord barrier. In transgenic mice carrying mutated SOD1 genes, a disrupted blood–spinal cord barrier as well as decreased levels of tight junction (TJ) proteins ZO-1, occludin, and claudin-5 were detected. Here, we examined TJ protein levels and barrier function of primary blood–spinal cord barrier endothelial cells of presymptomatic hSOD1G93…
Influence of mobile ions on the electroluminescence characteristics of methylammonium lead iodide perovskite diodes
2016
In this work, we study the effect of voltage bias on the optoelectronic behavior of methylammonium lead iodide planar diodes. Upon biasing the diodes with a positive voltage, the turn-on voltage of the electroluminescence diminishes and its intensity substantially increases. This behavior is reminiscent of that observed in light-emitting electrochemical cells (LECs), single-layer electroluminescent devices in which the charge injection is assisted by the accumulation of ions at the electrode interface. Because of this mechanism, performances are largely independent from the work function of the electrodes. The similarities observed between planar perovskite diodes and LECs suggest that mobi…